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Exogenous factors, such as oral contraceptives, hormone replacement therapy, and estradiol, may affect susceptibility to Candida infection, although the mechanisms involved in this process have not been elucidated. We used a systemic candidiasis model to investigate how estradiol confers susceptibility to infection. We report that estradiol increases mouse susceptibility to systemic candidiasis, as in vivo and ex vivo estradiol-treated DCs were less efficient at up-regulating antigen-presenting machinery, pathogen killing, migration, IL-23 production, and triggering of the Th17 immune response. Based on these results, we propose that estradiol impairs DC function, thus explaining the increased susceptibility to infection during estrus.<\/jats:p>","DOI":"10.1189\/jlb.1110645","type":"journal-article","created":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:27:48Z","timestamp":1317428868000},"page":"159-165","source":"Crossref","is-referenced-by-count":47,"title":["Estradiol impairs the Th17 immune response against\n                    <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"91","author":[{"given":"Miguel","family":"Relloso","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense , Madrid, Spain"},{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Aragoneses-Fenoll","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas, CSIC , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Lasarte","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Max F. Perutz Laboratories, Christian Doppler Laboratory for Infection Biology , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Romera","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Kuchler","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Max F. Perutz Laboratories, Christian Doppler Laboratory for Infection Biology , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel L","family":"Corb\u00ed","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas, CSIC , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Angeles","family":"Mu\u00f1oz-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Nombela","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L","family":"Rodr\u00edguez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas, CSIC , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Diez-Orejas","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,30]]},"reference":[{"key":"2023020612130825800_B1","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1093\/clinids\/14.Supplement_1.S148","article-title":"Pathogenesis and treatment of recurrent vulvovaginal candidiasis","volume":"14","author":"Sobel","year":"1992","journal-title":"Clin. 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