{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:29:52Z","timestamp":1788870592451,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,3,12]],"date-time":"2004-03-12T00:00:00Z","timestamp":1079049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ann Fook Yang from Agriculture Canada"},{"name":"Heart and Stroke Foundation of Ontario and the Canadian Institutes of Health Research"},{"name":"Canadian Institute of Health Research-University Industry Investigator"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mononuclear leukocytes infiltrate the artery wall via integrin-mediated mechanisms and play an integral role in intimal formation after stenting. We sought to determine if acute antagonism of the \u03b14 subunit of very late antigen-4 is sufficient for the late attenuation of stent intimal area (IA). Twenty-four hypercholesterolemic rabbits underwent iliac artery balloon injury, followed 2 weeks later by stent implantation, and the animals were randomized to receive an anti-\u03b14 antibody (HP1\/2) or a nonspecific isotypic control immunoglobulin (1E6) intravenously 1 h before stenting. Compared with controls, HP1\/2-treated rabbits showed 50%, 51%, and 44% reductions in the percentage on intimal cells that were macrophages on days 3, 7, and 28 after stenting and a 59% reduction in intimal proliferation on day 3. Although stent IA was reduced by 63% and 48% in the antibody-treated group compared with the control group on days 3 and 7, this difference was not present on day 28. These data highlight the need for sustained, anti-inflammatory therapies for the prevention of stent intimal formation.<\/jats:p>","DOI":"10.1189\/jlb.1203618","type":"journal-article","created":{"date-parts":[[2004,3,15]],"date-time":"2004-03-15T20:44:31Z","timestamp":1079383471000},"page":"1016-1021","source":"Crossref","is-referenced-by-count":9,"title":["Antagonism of the \u03b14 integrin subunit attenuates the acute inflammatory response to stent implantation yet is insufficient to prevent late intimal formation"],"prefix":"10.1093","volume":"75","author":[{"given":"Xiaoli","family":"Ma","sequence":"first","affiliation":[{"name":"Vascular Biology Laboratory, Division of Cardiology, University of Ottawa Heart Institute , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Vascular Biology Laboratory, Division of Cardiology, University of Ottawa Heart Institute , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,3,12]]},"reference":[{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0735-1097(02)02123-X","article-title":"Selection of coronary stents.","volume":"40","author":"Colombo","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"2023033100114840700_","first-page":"167","article-title":"Pathophysiological insights from studies of retrieved coronary atherectomy tissue.","volume":"5","author":"Glover","year":"2000","journal-title":"Semin. Interv. Cardiol."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/01.CIR.0000029209.89156.88","article-title":"Images in cardiovascular medicine. Stent inflammation: stent footprint in restenotic tissue retrieved by directional atherectomy.","volume":"106","author":"Meuwissen","year":"2002","journal-title":"Circulation"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.99.1.44","article-title":"Pathology of acute and chronic coronary stenting in humans.","volume":"99","author":"Farb","year":"1999","journal-title":"Circulation"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0735-1097(97)00450-6","article-title":"In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia.","volume":"31","author":"Kornowski","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1161\/01.ATV.0000037100.44766.5B","article-title":"Inflammation and restenosis in the stent era.","volume":"22","author":"Welt","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1172\/JCI117519","article-title":"The pathophysiologic role of \u03b14 integrins in vivo.","volume":"94","author":"Lobb","year":"1994","journal-title":"J. Clin. Invest."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1172\/JCI117962","article-title":"Blockade for very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts.","volume":"95","author":"Molossi","year":"1995","journal-title":"J. Clin. Invest."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0092-8674(90)90661-W","article-title":"VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4\/fibronectin binding site.","volume":"60","author":"Elices","year":"1990","journal-title":"Cell"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI116670","article-title":"Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.","volume":"92","author":"O\u2019Brien","year":"1993","journal-title":"J. Clin. Invest."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1161\/01.CIR.97.1.75","article-title":"Inhibition of \u03b14 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in apoE-deficient mice.","volume":"97","author":"Patel","year":"1998","journal-title":"Circulation"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/01.RES.84.3.345","article-title":"Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet.","volume":"84","author":"Shih","year":"1999","journal-title":"Circ. Res."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1161\/01.RES.77.6.1121","article-title":"Mononuclear leukocytes invade rabbit arterial intima during thickening formation via CD18- and VLA-4-dependent mechanisms and stimulate smooth muscle migration.","volume":"77","author":"Kling","year":"1995","journal-title":"Circ. Res."},{"key":"2023033100114840700_","first-page":"187","article-title":"Infusion of an anti\u03b14 integrin antibody is associated with less neoadventitial formation after balloon injury of porcine coronary arteries.","volume":"16","author":"Labinaz","year":"2000","journal-title":"Can. J. Cardiol."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0741-5214(97)70151-4","article-title":"Anti-VLA-4 antibody reduces intimal hyperplasia in the end-arterectomized carotid artery in non-human primates.","volume":"26","author":"Lumsden","year":"1997","journal-title":"J. Vasc. Surg."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"10241","DOI":"10.1016\/S0021-9258(18)99215-X","article-title":"Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4.","volume":"266","author":"Pulido","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1172\/JCI116686","article-title":"CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.","volume":"92","author":"Winn","year":"1993","journal-title":"J. Clin. Invest."},{"key":"2023033100114840700_","first-page":"873","article-title":"Focal arterial transgene expression after local gene delivery.","volume":"17","author":"Ma","year":"2001","journal-title":"Can. J. Cardiol."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1148\/radiology.160.3.2942964","article-title":"Atherosclerotic rabbit aortas: expandable intraluminal grafting.","volume":"160","author":"Palmaz","year":"1986","journal-title":"Radiology"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1161\/01.CIR.92.6.1570","article-title":"Low-dose radioactive endovascular stents prevent smooth muscle cell proliferation and neointimal hyperplasia in rabbits.","volume":"92","author":"Hehrlein","year":"1995","journal-title":"Circulation"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0735-1097(92)90476-4","article-title":"Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model.","volume":"19","author":"Schwartz","year":"1992","journal-title":"J. Am. Coll. Cardiol."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/abio.2002.5723","article-title":"A cell-free electrochemiluminescence assay for measuring \u03b21-integrin-ligand interactions.","volume":"306","author":"Weinreb","year":"2002","journal-title":"Anal. Biochem."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/1568006043481293","article-title":"Current understanding of in-stent restenosis and the potential benefit of drug eluting stents.","volume":"4","author":"Froeschl","year":"2004","journal-title":"Curr. Drug Targets Cardiovasc. Haematol. Disord."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/86394","article-title":"Circulating smooth muscle progenitor cells contribute to atherosclerosis.","volume":"7","author":"Saiura","year":"2001","journal-title":"Nat. Med."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.tcm.2003.09.002","article-title":"Involvement of progenitor cells in vascular repair.","volume":"13","author":"Hibbert","year":"2003","journal-title":"Trends Cardiovasc. Med."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"10134","DOI":"10.1073\/pnas.95.17.10134","article-title":"A mAb to the B2-leukocyte integrin Mac-1 (CD11b\/CD18) reduces intimal thickening after angioplasty or sent implantation in rabbits.","volume":"95","author":"Rogers","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/01.CIR.88.4.1788","article-title":"Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury.","volume":"88","author":"Tanaka","year":"1993","journal-title":"Circulation"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.1990440","article-title":"Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis.","volume":"251","author":"Cybulsky","year":"1991","journal-title":"Science"},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1161\/01.ATV.13.2.197","article-title":"An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium.","volume":"12","author":"Li","year":"1993","journal-title":"Arterioscler. Thromb."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1161\/01.ATV.20.7.1729","article-title":"Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice.","volume":"20","author":"Oguchi","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033100114840700_","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.RES.80.2.159","article-title":"The integrin very late antigen-4 is expressed in human smooth muscle cell. Involvement of \u03b14 and vascular cell adhesion molecule-1 during smooth muscle cell differentiation.","volume":"80","author":"Duplaa","year":"1997","journal-title":"Circ. Res."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.1203618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/75\/6\/1016\/49655726\/jlb1016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/75\/6\/1016\/49655726\/jlb1016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T23:48:49Z","timestamp":1682639329000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/75\/6\/1016\/6976391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,12]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,3,12]]},"published-print":{"date-parts":[[2004,6,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.1203618","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,6]]},"published":{"date-parts":[[2004,3,12]]}}}