{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T06:50:13Z","timestamp":1742799013204,"version":"3.37.3"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Center for Molecular Medicine"},{"DOI":"10.13039\/501100008001","name":"University of Cologne","doi-asserted-by":"publisher","award":["BMBF 01 KS 9502"],"award-info":[{"award-number":["BMBF 01 KS 9502"]}],"id":[{"id":"10.13039\/501100008001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 497-C7"],"award-info":[{"award-number":["SFB 497-C7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Absence of the common \u03b2 chain (CD18) of \u03b22 integrins leads to leukocyte-adhesion deficiency type-1 (LAD1) in humans. Mice with a CD18 null mutation suffer from recurrent bacterial infections, impaired wound healing, and skin ulcers, closely resembling human LAD1. Previous findings in CD18\u2212\/\u2212 mice demonstrated a skewed terminal B cell differentiation with plasmacytosis and elevated serum immunoglobulin G (IgG). As interleukin-6 (IL-6) is a potent enhancer of plasma cell formation and Ig secretion, we assessed IL-6 serum levels of CD18\u2212\/\u2212 and wild-type (WT) mice kept under a conventional or barrier facility or specific pathogen-free (SPF) conditions. We detected an up to 20-fold increase in IL-6 in serum of CD18\u2212\/\u2212 mice compared with WT controls when kept under conventional or barrier facility conditions, respectively. Under SPF conditions, no significant differences in terms of IL-6 serum levels were found between CD18\u2212\/\u2212 and WT mice. However, histological alterations of secondary lymphoid tissues, plasmacytosis, abnormal plasmacytoid cells (Mott cells), and hypergammaglobulinemia persisted. To further analyze the role of IL-6 in these pathological alterations, we established a CD18\u2212\/\u2212 IL-6\u2212\/\u2212 double-deficient mouse mutant. In these mice, serum IgG levels were normal, and the altered plasma cell phenotype, including Mott cells, was no longer detectable. The CD18\u2212\/\u2212 IL-6\u2212\/\u2212 double-deficient mouse model thus demonstrated that IL-6 is responsible for parts of the phenotype seen in the CD18\u2212\/\u2212 mouse mutants. It may be of interest to examine human leukocyte-adhesion deficiency type-1 patients closer and search for pathological changes possibly induced via overproduction of IL-6.<\/jats:p>","DOI":"10.1189\/jlb.1205740","type":"journal-article","created":{"date-parts":[[2006,7,15]],"date-time":"2006-07-15T01:54:59Z","timestamp":1152928499000},"page":"599-607","source":"Crossref","is-referenced-by-count":15,"title":["Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in \u03b22 integrin-deficient mice"],"prefix":"10.1093","volume":"80","author":[{"given":"Thorsten","family":"Peters","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergic Diseases, University of Ulm , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department for Molecular and Cellular Sports Medicine, Institute of Circulation Research and Sports Medicine , Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Wickenhauser","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Deprtments, University of Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Tawadros","sequence":"additional","affiliation":[{"name":"Departments of Medical Hematology and Oncology , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsvetelina","family":"Oreshkova","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergic Diseases, University of Ulm , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Kess","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergic Diseases, University of Ulm , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Krieg","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Center for Molecular Medicine (ZMMK), University of Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Society for Biotechnological Research (GBF) , Braunschweig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Scharffetter-Kochanek","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergic Diseases, University of Ulm , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"2023033007524246800_jlb0599-cit-B1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.137.1.15","article-title":"Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies","volume":"137","author":"Anderson","year":"1986","journal-title":"J. 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