{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:41:37Z","timestamp":1754109697849},"reference-count":151,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T00:00:00Z","timestamp":1172016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The immune system modulates a number of biological processes to properly defend against pathogens. Here, we review how crosstalk between nuclear hormone receptors and the innate immune system may influence multiple biological functions during an immune response. Although nuclear hormone receptor repression of innate immune responses and inflammation has been well studied, a number of new studies have identified repression of nuclear hormone receptor signaling by various innate immune responses. IFN regulatory factor 3, a key transcription factor involved in the induction of antiviral genes, may play a role in mediating such crosstalk between the innate immune response and nuclear receptor-regulated metabolism. This crosstalk mechanism is now implicated in the pathogenesis of atherosclerosis and Reye\u2019s syndrome and could provide an explanation for other pathogen-associated metabolic and developmental disorders.<\/jats:p>","DOI":"10.1189\/jlb.1206741","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T02:02:07Z","timestamp":1172109727000},"page":"187-195","source":"Crossref","is-referenced-by-count":20,"title":["Innate immune system regulation of nuclear hormone receptors in metabolic diseases"],"prefix":"10.1093","volume":"82","author":[{"given":"Edward Kai-Hua","family":"Chow","sequence":"first","affiliation":[{"name":"Molecular Biology Institute, University of California Los Angeles , Los Angeles, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahram","family":"Razani","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genhong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Molecular Biology Institute, University of California Los Angeles , Los Angeles, California , USA"},{"name":"Department of Microbiology, Immunology and Molecular Genetics , Los Angeles, California , USA"},{"name":"Jonsson Comprehensive Cancer Center , Los Angeles, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,2,21]]},"reference":[{"key":"2023033006500303500_","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1530\/eje.0.1380603","article-title":"Role of cytokines in the pathogenesis of the euthyroid sick syndrome","volume":"138","author":"Bartalena","year":"1998","journal-title":"Eur. 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