{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:23:50Z","timestamp":1773278630420,"version":"3.50.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T00:00:00Z","timestamp":1210636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI38348"],"award-info":[{"award-number":["AI38348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI50209"],"award-info":[{"award-number":["AI50209"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"La Jolla Institute for Allergy and Immunology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antigen-dependent activation of IgE-bound mast cells is critical for immediate hypersensitivity and other allergic disorders. Recent studies have revealed the effects of monomeric IgEs on mast cell survival and activation. Furthermore, IgE molecules exhibit a wide range of heterogeneity in the ability to induce mast cell activation in the absence of antigen. Highly cytokinergic (HC) IgEs can induce a variety of activation events including cell survival, degranulation, cytokine production, and migration, whereas poorly cytokinergic (PC) IgEs can do so inefficiently. Here, we show that culture of bone marrow cells in the presence of monomeric IgEs results in an increased number of mast cells compared with cultures grown without IgE. Furthermore, time in culture required to generate \u226580% pure mast cells is decreased. IgE molecules can directly influence mast cell progenitors to differentiate into mast cells. mRNA expression of several mast cell proteases and mast cell-related transcription factors is higher in mast cells cultured with an HC IgE than those cultured with a PC IgE or without IgE. Expression of early growth response factor-1, a transcription factor that is involved in the production of TNF-\u03b1 in mast cells, is enhanced in cultures containing high and low concentrations of HC IgE and a high concentration of PC IgE. Consistent with this, expression of TNF-\u03b1 is higher in mast cells cultured with HC IgE than PC IgE. Therefore, our results suggest that monomeric IgEs, especially HC IgEs, not only promote mast cell development but also modulate the mast cell phenotype.<\/jats:p>","DOI":"10.1189\/jlb.1207841","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T01:09:52Z","timestamp":1210727392000},"page":"357-367","source":"Crossref","is-referenced-by-count":21,"title":["Pivotal Advance: IgE accelerates in vitro development of mast cells and modifies their phenotype"],"prefix":"10.1093","volume":"84","author":[{"given":"Jun-ichi","family":"Kashiwakura","sequence":"first","affiliation":[{"name":"Division of Cell Biology, La Jolla Institute for Allergy and Immunology , La Jolla , California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, La Jolla Institute for Allergy and Immunology , La Jolla , California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Kitaura","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, La Jolla Institute for Allergy and Immunology , La Jolla , California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, La Jolla Institute for Allergy and Immunology , La Jolla , California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Maeda-Yamamoto","sequence":"additional","affiliation":[{"name":"National Research Institute of Vegetables and Tea Science, National Agriculture Research Organization , Shizuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet R","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cancer Research and Treatment Center, University of New Mexico School of Medicine , Albuquerque, New Mexico , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget S","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cancer Research and Treatment Center, University of New Mexico School of Medicine , Albuquerque, New Mexico , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Blank","sequence":"additional","affiliation":[{"name":"Inserm U699 and Universit\u00e9 Paris 7-Diderot, Facult\u00e9 de M\u00e9decine, Site Xavier Bichat , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, La Jolla Institute for Allergy and Immunology , La Jolla , California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,5,13]]},"reference":[{"key":"2023032712484183200_","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0952-7915(99)80010-7","article-title":"Mast cells as sentinels of innate immunity","volume":"11","author":"Galli","year":"1999","journal-title":"Curr. 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