{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:25:46Z","timestamp":1788870346430,"version":"build-2803163510"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":3827,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2007-0612"],"award-info":[{"award-number":["2007-0612"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2010-34397-21391"],"award-info":[{"award-number":["2010-34397-21391"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009502","name":"Montana Agricultural Experiment Station","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009502","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Agriculture Formula Funds"},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"crossref","award":["P20 RR020185"],"award-info":[{"award-number":["P20 RR020185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000937","name":"M. J. Murdock Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Osteoarticular and soft tissue inflammation occur in subsequent infection with wild-type Brucella in mice deficient of IFN-\u03b3, resembling aspects of human disease.<\/jats:p>\n                  <jats:p>Human brucellosis exhibits diverse pathological manifestations that can affect almost any organ. In particular, osteoarticular complications are the most common focal manifestation of brucellosis and occur in 40\u201380% of patients. In immunocompetent mice, Brucella replication is generally restricted to the spleen, liver, and to a lesser extent, LNs, thereby limiting their use for study of focal inflammation often found in brucellosis. Here, we report that nasal, oral, or peritoneal infection of IFN-\u03b3\u2212\/\u2212 mice with WT Brucella melitensis or Brucella abortus results in joint and periarticular tissue inflammation. Histological analysis of the affected joints revealed inflammatory infiltrates and debris within the joint space colocalizing with Brucella antigen. Osteoarthritis, necrosis, periarticular soft tissue inflammation, and substantial brucellae burdens were observed. Oral rifampicin was effective in clearing infection and halting further progression of focal inflammation from infected IFN-\u03b3\u2212\/\u2212 mice, although some symptoms and swelling remained. Elevated IL-1\u03b2, but not TNF-\u03b1, IL-6, or IL-17, was detected in joint homogenates from infected IFN-\u03b3\u2212\/\u2212 mice. Whereas more susceptible to systemic infection, IL-1R\u2212\/\u2212 mice depleted of IFN-\u03b3 were more resistant to focal inflammation than WT mice similarly depleted of IFN-\u03b3. Collectively, these results show IFN-\u03b3\u2212\/\u2212 mice represent a potential model for study of focal inflammation attributed to Brucella infection and will allow evaluation of intervention strategies targeting IL-1, IL-1R, or other inflammatory mediators, with the potential to complement antibiotic-based therapies.<\/jats:p>","DOI":"10.1189\/jlb.1211626","type":"journal-article","created":{"date-parts":[[2012,5,26]],"date-time":"2012-05-26T01:21:43Z","timestamp":1337995303000},"page":"375-387","source":"Crossref","is-referenced-by-count":30,"title":["IFN-\u03b3-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis"],"prefix":"10.1093","volume":"92","author":[{"given":"Jerod A","family":"Skyberg","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kochetkova","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Layton","sequence":"additional","affiliation":[{"name":"Montana Veterinary Diagnostic Laboratory , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle","family":"Callis","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaryClare F","family":"Rollins","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Riccardi","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Golden","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"2023012401093915600_B1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"2023012401093915600_B2","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/infdis\/170.5.1216","article-title":"Changing trends in the epidemiology of human brucellosis in California from 1973 to 1992: a shift toward foodborne transmission","volume":"170","author":"Chomel","year":"1994","journal-title":"J. Infect. Dis."},{"key":"2023012401093915600_B3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","article-title":"Brucellosis: an overview","volume":"3","author":"Corbel","year":"1997","journal-title":"Emerg. Infect. Dis."},{"key":"2023012401093915600_B4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/ard.50.1.23","article-title":"Osteoarticular complications of brucellosis","volume":"50","author":"Colmenero","year":"1991","journal-title":"Ann. Rheum. Dis."},{"key":"2023012401093915600_B5","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/clinids\/20.5.1241","article-title":"Characteristics of and risk factors for relapse of brucellosis in humans","volume":"20","author":"Ariza","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"2023012401093915600_B6","first-page":"401","article-title":"Human brucellosis","volume":"15","author":"Sauret","year":"2002","journal-title":"J. Am. Board Fam. Pract."},{"key":"2023012401093915600_B7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0950-3579(05)80153-0","article-title":"Bacterial infections: osteoarticular brucellosis","volume":"9","author":"Rajapakse","year":"1995","journal-title":"Baillieres Clin. Rheumatol."},{"key":"2023012401093915600_B8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0049-0172(82)90064-6","article-title":"Articular involvement in human brucellosis: a retrospective analysis of 304 cases","volume":"12","author":"Gotuzzo","year":"1982","journal-title":"Semin. Arthritis Rheum."},{"key":"2023012401093915600_B9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1201-9712(02)90108-6","article-title":"Brucellosis in children: clinical observations in 115 cases","volume":"6","author":"Shaalan","year":"2002","journal-title":"Int. J. Infect. Dis."},{"key":"2023012401093915600_B10","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/ard.49.11.896","article-title":"Osteoarticular brucellosis in children","volume":"49","author":"al Eissa","year":"1990","journal-title":"Ann. Rheum. Dis."},{"key":"2023012401093915600_B11","first-page":"727","article-title":"Osteoarticular involvement in brucellosis: study of 196 cases in the Republic of Macedonia","volume":"45","author":"Bosilkovski","year":"2004","journal-title":"Croat. Med. J."},{"key":"2023012401093915600_B12","article-title":"Arthroscopic synovectomy, an alternative in the treatment of brucellar arthritis of the knee with prolonged course. A report of two cases","volume":"13","author":"Martin-Hernandez","year":"2009","journal-title":"Int. J. Orthopedic Surg."},{"key":"2023012401093915600_B13","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.2169\/internalmedicine.47.1108","article-title":"Acute onset myositis associated with brucellosis, quite a rare diagnosis","volume":"47","author":"Celik","year":"2008","journal-title":"Intern. 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Dis."},{"key":"2023012401093915600_B27","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/thx.51.12.1253","article-title":"Increased inflammatory cytokines and new collagen formation in cutaneous tuberculosis and sarcoidosis","volume":"51","author":"Marshall","year":"1996","journal-title":"Thorax"},{"key":"2023012401093915600_B28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/iai.61.1.124-134.1993","article-title":"Effects of cytokines on intracellular growth","volume":"61","author":"Jiang","year":"1993","journal-title":"of Brucella abortus. Infect. Immun."},{"key":"2023012401093915600_B29","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1128\/iai.59.5.1790-1794.1991","article-title":"Prophylaxis or treatment of experimental brucellosis with interleukin-1","volume":"59","author":"Zhan","year":"1991","journal-title":"Infect. 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Immunol."},{"key":"2023012401093915600_B33","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1128\/IAI.05080-11","article-title":"Protective live oral brucellosis vaccines stimulate Th1 and Th17 cell responses","volume":"79","author":"Clapp","year":"2011","journal-title":"Infect. Immun."},{"key":"2023012401093915600_B34","doi-asserted-by":"crossref","first-page":"394021","DOI":"10.1155\/2009\/394021","article-title":"IL-4 deficiency decreases mortality but increases severity of arthritis in experimental group B Streptococcus infection","volume":"2009","author":"Tissi","year":"2009","journal-title":"Mediators Inflamm."},{"key":"2023012401093915600_B35","article-title":"IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10","volume":"184","author":"Kochetkova","year":"2010","journal-title":"J. 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Immunol."},{"key":"2023012401093915600_B41","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1128\/IAI.71.6.3437-3442.2003","article-title":"Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with","volume":"71","author":"Burchill","year":"2003","journal-title":"Borrelia burgdorferi. Infect. Immun."},{"key":"2023012401093915600_B42","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2567.2001.01258.x","article-title":"Interferon-\u03b3 is crucial for surviving a Brucella abortus infection in both resistant C57BL\/6 and susceptible BALB\/c mice","volume":"103","author":"Murphy","year":"2001","journal-title":"Immunology"},{"key":"2023012401093915600_B43","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/eji.200425124","article-title":"Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR \u03b3\u03b4 T cells and interleukin-18-binding protein","volume":"34","author":"Siegmund","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"2023012401093915600_B44","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1600-0897.2005.00329.x","article-title":"Unraveling Brucella genomics and pathogenesis in immunocompromised IRF-1\u2212\/- mice","volume":"54","author":"Rajashekara","year":"2005","journal-title":"Am. J. Reprod. Immunol."},{"key":"2023012401093915600_B45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1179\/joc.2008.20.1.58","article-title":"Comparison of rifampicin and moxifloxacin efficacy in an experimental model of animal brucellosis","volume":"20","author":"Sezak","year":"2008","journal-title":"J. Chemother."},{"key":"2023012401093915600_B46","article-title":"Effect of rifampicin and tetracycline alone and in combination against","volume":"131B","author":"De Rycke","year":"1980","journal-title":"Brucella suis. Ann. Microbiol. (Paris)"},{"key":"2023012401093915600_B47","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s100960050344","article-title":"Ciprofloxacin and rifampicin versus doxycycline and rifampicin in the treatment of brucellosis","volume":"18","author":"Agalar","year":"1999","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"2023012401093915600_B48","first-page":"921","article-title":"Efficacy of rifampicin plus doxycycline versus rifampicin plus quinolone in the treatment of brucellosis","volume":"23","author":"Saltoglu","year":"2002","journal-title":"Saudi Med. J."},{"key":"2023012401093915600_B49","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.bbrc.2004.08.187","article-title":"4-Epidoxycycline: an alternative to doxycycline to control gene expression in conditional mouse models","volume":"323","author":"Eger","year":"2004","journal-title":"Biochem. Biophys. Res. 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Invest."},{"key":"2023012401093915600_B53","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1128\/CVI.00029-09","article-title":"Development and characterization of mouse models of infection with aerosolized Brucella melitensis and Brucella suis","volume":"16","author":"Smither","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"key":"2023012401093915600_B54","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/j.1462-5822.2005.00570.x","article-title":"Temporal analysis of pathogenic events in virulent and avirulent Brucella melitensis infections","volume":"7","author":"Rajashekara","year":"2005","journal-title":"Cell. 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Sci."},{"key":"2023012401093915600_B57","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jinf.2005.11.024","article-title":"Dominant Th1 cytokine production in early onset of human brucellosis followed by switching towards Th2 along prolongation of disease","volume":"53","author":"Rafiei","year":"2006","journal-title":"J. Infect."},{"key":"2023012401093915600_B58","first-page":"250","article-title":"Inflammatory bowel disease: lessons from the IL-10 gene-deficient mouse","volume":"24","author":"Madsen","year":"2001","journal-title":"Clin. Invest. Med."},{"key":"2023012401093915600_B59","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/JVI.73.1.783-786.1999","article-title":"New mouse model for dengue virus vaccine testing","volume":"73","author":"Johnson","year":"1999","journal-title":"J. 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Microbiol."},{"key":"2023012401093915600_B63","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.bbrc.2010.04.113","article-title":"Therapeutic effect of (Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl) acrylonitrile (DMMA) against Staphylococcus aureus infection in a murine model","volume":"396","author":"Oh","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl 3","key":"2023012401093915600_B64","first-page":"E64","article-title":"Soft tissue and joint infection","volume":"14","author":"Wilson","year":"2004","journal-title":"Eur. Radiol."},{"key":"2023012401093915600_B65","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ijsu.2007.07.001","article-title":"Microbiology and management of soft tissue and muscle infections","volume":"6","author":"Brook","year":"2008","journal-title":"Int. J. Surg."},{"key":"2023012401093915600_B66","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.4049\/jimmunol.171.11.6173","article-title":"Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice","volume":"171","author":"Nakae","year":"2003","journal-title":"J. Immunol."},{"key":"2023012401093915600_B67","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1574-695X.2008.00431.x","article-title":"Role of IL-17, transforming growth factor-\u03b2, and IL-6 in the development of arthritis and production of anti-outer surface protein A borreliacidal antibodies in Borrelia-vaccinated and -challenged mice","volume":"53","author":"Nardelli","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"2023012401093915600_B68","first-page":"S105","article-title":"TNF \u03b1 and IL-1 \u03b2 are separate targets in chronic arthritis","volume":"17","author":"Van den Berg","year":"1999","journal-title":"Clin. Exp. Rheumatol."},{"key":"2023012401093915600_B69","first-page":"5937","article-title":"TNF\/lymphotoxin-\u03b1 double-mutant mice resist septic arthritis but display increased mortality in response to","volume":"161","author":"Hultgren","year":"1998","journal-title":"Staphylococcus aureus. J. Immunol."},{"key":"2023012401093915600_B70","doi-asserted-by":"crossref","first-page":"e21978","DOI":"10.1371\/journal.pone.0021978","article-title":"Murine and bovine \u03b3\u03b4 T cells enhance innate immunity against Brucella abortus infections","volume":"6","author":"Skyberg","year":"2011","journal-title":"PLoS ONE"},{"key":"2023012401093915600_B71","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1001\/jama.295.19.2275","article-title":"Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials","volume":"295","author":"Bongartz","year":"2006","journal-title":"JAMA"},{"key":"2023012401093915600_B72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3904\/kjim.2009.24.4.397","article-title":"A case of tuberculous arthritis following the use of etanercept","volume":"24","author":"Choi","year":"2009","journal-title":"Korean J. Intern. Med."},{"key":"2023012401093915600_B73","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.3899\/jrheum.090276","article-title":"Septic arthritis caused by Rothia dentocariosa in a patient with rheumatoid arthritis receiving etanercept therapy","volume":"36","author":"Favero","year":"2009","journal-title":"J. Rheumatol."},{"key":"2023012401093915600_B74","first-page":"573","article-title":"In situ detection and distribution of inflammatory cytokines during the course of infection with","volume":"23","author":"Solis-Soto","year":"2008","journal-title":"Nocardia brasiliensis. Histol. Histopathol."},{"key":"2023012401093915600_B75","doi-asserted-by":"crossref","first-page":"425","DOI":"10.4269\/ajtmh.1999.61.425","article-title":"Increased serum levels of interferon-\u03b3 and interleukin-12 during human brucellosis","volume":"61","author":"Ahmed","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2023012401093915600_B76","first-page":"1343","article-title":"Concentration of interleukin-1 \u03b2 in serum and synovial fluid in patients with rheumatoid arthritis and those with osteoarthritis","volume":"63","author":"Mannami","year":"1989","journal-title":"Nippon Seikeigeka Gakkai Zasshi"},{"key":"2023012401093915600_B77","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1128\/IAI.05289-11","article-title":"IL-1 receptor-associated kinase 4 (IRAK-4) is essential for initial host control of Brucella abortus infection","volume":"79","author":"Oliveira","year":"2011","journal-title":"Infect. 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