{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T01:21:53Z","timestamp":1768180913259,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Victorian State Government Operational Infrastructure Support Program"},{"DOI":"10.13039\/501100000925","name":"Australian Government National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Independent Research Institutes Infrastructure Support Scheme"},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["516786"],"award-info":[{"award-number":["516786"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1022144"],"award-info":[{"award-number":["1022144"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1062683"],"award-info":[{"award-number":["1062683"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Research Board Ireland and Marie Curie Foundations","award":["MCPD\/2009\/2"],"award-info":[{"award-number":["MCPD\/2009\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aicda is a critical component of antibody class-switching in B cells. In this work, we study the impact of TLR4 activation and IL-10 stimulation on Aicda expression in B cells. Through the global analysis of miRNAs in response to TLR4 activation, in combination with IL-10 stimulation, we identified that IL-10 can suppress TLR4-induced miR-155 expression, an effect that resulted in enhanced Aicda expression. Furthermore, when preventing miR-155 control of Aicda expression, by genetic mutation of its target site in the Aicda mRNA, IL-10 could further potentiate Aicda expression. Given that miR-155 expression is lost, and expression levels of both Aicda and IL-10 are high in diseases, such as Burkitt\u2019s lymphoma, our results suggest a stringent and sophisticated control of Aicda by a novel IL-10\/miR-155 axis, where the imbalance of IL-10 and\/or miR-155 may contribute to disease pathogenesis.<\/jats:p>","DOI":"10.1189\/jlb.2a0314-178r","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T04:04:22Z","timestamp":1415419462000},"page":"71-78","source":"Crossref","is-referenced-by-count":23,"title":["IL-10 regulates <i>Aicda<\/i> expression through miR-155"],"prefix":"10.1093","volume":"97","author":[{"given":"Kirsten A","family":"Fairfax","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Immunology, Monash University , Prahran, Victoria , Australia"},{"name":"Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research , Melbourne , Australia"},{"name":"The Department of Experimental Medicine, University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P","family":"Gantier","sequence":"additional","affiliation":[{"name":"Centre for Cancer Research, Monash Institute of Medical Research\u2013Prince Henry\u2019s Institute of Medical Research , Clayton, Victoria , Australia"},{"name":"Department of Molecular and Translational Science, Monash University , Clayton, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Mackay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Immunology, Monash University , Prahran, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan R G","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre for Cancer Research, Monash Institute of Medical Research\u2013Prince Henry\u2019s Institute of Medical Research , Clayton, Victoria , Australia"},{"name":"Department of Molecular and Translational Science, Monash University , Clayton, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire E","family":"McCoy","sequence":"additional","affiliation":[{"name":"Centre for Cancer Research, Monash Institute of Medical Research\u2013Prince Henry\u2019s Institute of Medical Research , Clayton, Victoria , Australia"},{"name":"Department of Molecular and Translational Science, Monash University , Clayton, Victoria , Australia"},{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"2023013012350935000_B1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.174.5.1209","article-title":"Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes","volume":"174","author":"De Waal Malefyt","year":"1991","journal-title":"J. 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