{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:15:46Z","timestamp":1790702146684,"version":"4.1.0"},"reference-count":128,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T00:00:00Z","timestamp":1410307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["491\/10"],"award-info":[{"award-number":["491\/10"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["747\/13"],"award-info":[{"award-number":["747\/13"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministries of Health and Science","award":["3-4114"],"award-info":[{"award-number":["3-4114"]}]},{"name":"Ministries of Health and Science","award":["3-6540"],"award-info":[{"award-number":["3-6540"]}]},{"name":"Ministries of Health and Science","award":["3-10151"],"award-info":[{"award-number":["3-10151"]}]},{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alexander Smidoda"},{"name":"Taubenblatt Family Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>WIP plays an important role in the remodeling of the actin cytoskeleton, which controls cellular activation, proliferation, and function. WIP regulates actin polymerization by linking the actin machinery to signaling cascades. WIP binding to WASp and to its homolog, N-WASp, which are central activators of the actin-nucleating complex Arp2\/3, regulates their cellular distribution, function, and stability. By binding to WASp, WIP protects it from degradation and thus, is crucial for WASp retention. Indeed, most mutations that result in WAS, an X-linked immunodeficiency caused by defective\/absent WASp activity, are located in the WIP-binding region of WASp. In addition, by binding directly to actin, WIP promotes the formation and stabilization of actin filaments. WASp-independent activities of WIP constitute a new research frontier and are discussed extensively in this article. Here, we review the current information on WIP in human and mouse systems, focusing on its associated proteins, its molecular-regulatory mechanisms, and its role as a key regulator of actin-based processes in the immune system.<\/jats:p>","DOI":"10.1189\/jlb.2ru0314-162r","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T07:16:50Z","timestamp":1410419810000},"page":"713-727","source":"Crossref","is-referenced-by-count":34,"title":["WIP: more than a WASp-interacting protein"],"prefix":"10.1093","volume":"96","author":[{"given":"Sophia","family":"Fried","sequence":"first","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Ramat-Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omri","family":"Matalon","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Ramat-Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Noy","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Ramat-Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Barda-Saad","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Ramat-Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,10]]},"reference":[{"key":"2023032708463193700_","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1182\/asheducation-2009.1.132","article-title":"New insights into the biology of Wiskott-Aldrich syndrome (WAS)","volume":"2009","author":"Thrasher","year":"2009","journal-title":"Hematol. 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