{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:56:17Z","timestamp":1760298977794,"version":"3.37.3"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"publisher","award":["1K08CA160662-01A1"],"award-info":[{"award-number":["1K08CA160662-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>LM escape immune surveillance, in part, as a result of the expansion of CD11b+MC, which alter the intrahepatic microenvironment to promote tumor tolerance. HBC make up a significant proportion of liver lymphocytes and appear to delay tumor progression; however, their significance in the setting of LM is poorly defined. Therefore, we characterized HBC and HBC\/CD11b+MC interactions using a murine model of LM. Tumor-bearing livers showed a trend toward elevated absolute numbers of CD19+ HBC. A significant increase in the frequency of IgMloIgDhi mature HBC was observed in mice with LM compared with normal mice. HBC derived from tumor-bearing mice demonstrated increased proliferation in response to TLR and BCR stimulation ex vivo compared with HBC from normal livers. HBC from tumor-bearing livers exhibited significant down-regulation of CD80 and were impaired in inducing CD4+ T cell proliferation ex vivo. We implicated hepatic CD11b+MC as mediators of CD80 down-modulation on HBC ex vivo via a CD11b-dependent mechanism that required cell-to-cell contact and STAT3 activity. Therefore, CD11b+MC may compromise the ability of HBC to promote T cell activation in the setting of LM as a result of diminished expression of CD80. Cross-talk between CD11b+MC and HBC may be an important component of LM-induced immunosuppression.<\/jats:p>","DOI":"10.1189\/jlb.3a0114-012rr","type":"journal-article","created":{"date-parts":[[2014,8,2]],"date-time":"2014-08-02T08:21:12Z","timestamp":1406967672000},"page":"883-894","source":"Crossref","is-referenced-by-count":15,"title":["Liver metastases induce reversible hepatic B cell dysfunction mediated by Gr-1+CD11b+ myeloid cells"],"prefix":"10.1093","volume":"96","author":[{"given":"Mitchell","family":"Thorn","sequence":"first","affiliation":[{"name":"Roger Williams Medical Center, Department of Surgery , Providence, Rhode Island, USA"},{"name":"\u2020Boston University School of Medicine , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary R","family":"Point","sequence":"additional","affiliation":[{"name":"Roger Williams Medical Center, Department of Surgery , Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A","family":"Burga","sequence":"additional","affiliation":[{"name":"Roger Williams Medical Center, Department of Surgery , Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cang T","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Roger Williams Medical Center, Department of Surgery , Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Joseph Espat","sequence":"additional","affiliation":[{"name":"Roger Williams Medical Center, Department of Surgery , Providence, Rhode Island, USA"},{"name":"\u2020Boston University School of Medicine , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C","family":"Katz","sequence":"additional","affiliation":[{"name":"Roger Williams Medical Center, Department of Surgery , Providence, Rhode Island, USA"},{"name":"\u2020Boston University School of Medicine , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"2023032708462920900_","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.4049\/jimmunol.1300826","article-title":"Hepatocytes contribute to immune regulation in the liver by activation of the notch signaling pathway in T cells","volume":"191","author":"Burghardt","year":"2013","journal-title":"J. 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