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In ACD, DCs can interact with PMNs that are recruited and activated, leading, in particular, to ectosome release. The objective of this work was to characterize the effects of PMN-Ect on DC functions in an ACD context. We first developed a standardized protocol to produce, characterize, and quantify ectosomes by use of human PLB-985 cells, differentiated into mature PMN (PLB-Ect). We then studied the in vitro effects of these purified ectosomes on human moDC functions in response to NiSO4 and to LPS, another TLR4 agonist. Confocal fluorescence microscopy showed that PLB-Ect was internalized by moDCs and localized in the lysosomal compartment. We then showed that PLB-Ect down-regulated NiSO4-induced moDC maturation, as witnessed by decreased expression of CD40, CD80, CD83, CD86, PDL-1, and HLA-DR and by decreased levels of IL-1\u03b2, IL-6, TNF-\u03b1, and IL-12p40 mRNAs. These effects were related to p38MAPK and NF-\u03baB down-regulation. However, no increase in pan-regulatory DC marker genes (GILZ, CATC, C1QA) was observed; rather, levels of effector DC markers (Mx1, NMES1) were increased. Finally, when these PLB-Ect + NiSO4-treated moDCs were cocultured with CD4+ T cells, a Th2 cytokine profile seemed to be induced, as shown, in particular, by enhanced IL-13 production. Together, these results suggest that the PMN-Ect can modulate DC maturation in response to nickel, a common chemical sensitizer responsible for ADC.<\/jats:p>","DOI":"10.1189\/jlb.3a0314-132rr","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T05:07:19Z","timestamp":1423717639000},"page":"737-749","source":"Crossref","is-referenced-by-count":20,"title":["Ectosomes from neutrophil-like cells down-regulate nickel-induced dendritic cell maturation and promote Th2 polarization"],"prefix":"10.1093","volume":"97","author":[{"given":"Isabelle","family":"Turbica","sequence":"first","affiliation":[{"name":"INSERM, UMR 996, Faculte\u00b4 de Pharmacie, Univ. 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