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This pathologic condition is called Jordans\u2019 anomaly, in which functional consequences have not been investigated. In the present study, we tested the hypothesis that ATGL plays a role in leukocyte LD metabolism and immune cell function. Similar to humans with loss-of-function mutations in ATGL, we found that global and myeloid-specific Atgl\u2212\/\u2212 mice exhibit Jordans\u2019 anomaly with increased abundance of intracellular TG-rich LDs in neutrophil granulocytes. In a model of inflammatory peritonitis, lipid accumulation was also observed in monocytes and macrophages but not in eosinophils or lymphocytes. Neutrophils from Atgl\u2212\/\u2212 mice showed enhanced immune responses in vitro, which were more prominent in cells from global compared with myeloid-specific Atgl\u2212\/\u2212 mice. Mechanistically, ATGL\u2212\/\u2212 as well as pharmacological inhibition of ATGL led to an impaired release of lipid mediators from neutrophils. These findings demonstrate that the release of lipid mediators is dependent on the liberation of precursor molecules from the TG-rich pool of LDs by ATGL. Our data provide mechanistic insights into Jordans\u2019 anomaly in neutrophils and suggest that ATGL is a potent regulator of immune cell function and inflammatory diseases.<\/jats:p>","DOI":"10.1189\/jlb.3a0515-206r","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T21:36:04Z","timestamp":1435181764000},"page":"837-850","source":"Crossref","is-referenced-by-count":90,"title":["Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis"],"prefix":"10.1093","volume":"98","author":[{"given":"Stefanie","family":"Schlager","sequence":"first","affiliation":[{"name":"Institutes of Molecular Biology and Biochemistry , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Goeritzer","sequence":"additional","affiliation":[{"name":"Institutes of Molecular Biology and Biochemistry , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Jandl","sequence":"additional","affiliation":[{"name":"Institutes of Experimental and Clinical Pharmacology , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Frei","sequence":"additional","affiliation":[{"name":"Institutes of Experimental and Clinical Pharmacology , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nemanja","family":"Vujic","sequence":"additional","affiliation":[{"name":"Institutes of Molecular Biology and Biochemistry , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Kolb","sequence":"additional","affiliation":[{"name":"Center for Medical Research , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heimo","family":"Strohmaier","sequence":"additional","affiliation":[{"name":"Center for Medical Research , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Dorow","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig , Leipzig , Germany"},{"name":"LIFE\u2013Leipzig Research Center for Civilization Diseases, University of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O","family":"Eichmann","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Rosenberger","sequence":"additional","affiliation":[{"name":"Division of Hematology, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"W\u00f6lfler","sequence":"additional","affiliation":[{"name":"Division of Hematology, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Lass","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences, University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E","family":"Kershaw","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Ceglarek","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig , Leipzig , Germany"},{"name":"LIFE\u2013Leipzig Research Center for Civilization Diseases, University of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dichlberger","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, University of Helsinki , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Heinemann","sequence":"additional","affiliation":[{"name":"Institutes of Experimental and Clinical Pharmacology , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Kratky","sequence":"additional","affiliation":[{"name":"Institutes of Molecular Biology and Biochemistry , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"2023013012480319100_B1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.0954-6820.1953.tb07038.x","article-title":"The familial occurrence of fat containing vacuoles in the leukocytes diagnosed in two brothers suffering from dystrophia musculorum progressiva (ERB.)","volume":"145","author":"Jordans","year":"1953","journal-title":"Acta Med. 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