{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:59:19Z","timestamp":1777528759769,"version":"3.51.4"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"U. S. 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The \u03b1(1,3)-fucose-containing sialyl-Lewis X (sLeX) is the archetypical ligand on leukocyte surfaces mediating selectin interactions. Canonically, disruption of \u03b1(1,3)-fucose formation ablates selectin-mediated adhesion, dramatically reducing trafficking. We report a paradoxical response to \u03b1(1,3)-fucose deficiency in which the loss exacerbated rather than attenuated leukocyte recruitment in a murine model of acute airway inflammation. The architecture of the capillary-dominated vasculature in the lung minimized the importance of the selectin dependent step, and we observed that \u03b1(1,3)-fucose deficiency augmented CXCR2-mediated Rap1-GTP signaling to enhance the \u03b22-integrin-ICAM-1-binding axis. The data disclose a previously unknown function for \u03b1(1,3)-fucose, in which this structure negatively regulates the integrin activation step in leukocyte recruitment.<\/jats:p>","DOI":"10.1189\/jlb.3a0516-215rr","type":"journal-article","created":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T01:29:58Z","timestamp":1472261398000},"page":"459-470","source":"Crossref","is-referenced-by-count":11,"title":["Leukocyte-borne \u03b1(1,3)-fucose is a negative regulator of \u03b22-integrin-dependent recruitment in lung inflammation"],"prefix":"10.1093","volume":"101","author":[{"given":"Alexander","family":"Buffone","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Cancer Institute , Buffalo, New York , USA"},{"name":"Department of Chemical and Biological Engineering, State University of New York at Buffalo , Buffalo, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrab","family":"Nasirikenari","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Cancer Institute , Buffalo, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles T","family":"Manhardt","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Cancer Institute , Buffalo, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Lugade","sequence":"additional","affiliation":[{"name":"Department of Immunology, Roswell Park Cancer Institute , Buffalo, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N","family":"Bogner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Roswell Park Cancer Institute , Buffalo, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sackstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brigham & Women\u2019s Hospital, Harvard Medical School , Boston, Massachusetts , USA"},{"name":"Department of Medicine, Brigham & Women\u2019s Hospital, Harvard Medical School , Boston, Massachusetts , USA"},{"name":"Program of Excellence in Glycosciences, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Thanavala","sequence":"additional","affiliation":[{"name":"Department of Immunology, Roswell Park Cancer Institute , Buffalo, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sriram","family":"Neelamegham","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, State University of New York at Buffalo , Buffalo, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph T Y","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Cancer Institute , Buffalo, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"2023011712055862200_B1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. 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