{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:17:22Z","timestamp":1787429842944,"version":"build-2736575974"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["521-2011-2414"],"award-info":[{"award-number":["521-2011-2414"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Society of Go\u00a8teborg"},{"name":"Swedish Association against Rheumatism"},{"name":"King Gustaf V\u2019s"},{"name":"Commission of European Union","award":["FP7-Health-261460"],"award-info":[{"award-number":["FP7-Health-261460"]}]},{"name":"Torsten So\u00a8derberg\u2019s Foundation, Rune and Ulla Amlo\u00a8vs Trust"},{"name":"IngaBritt and Arne Lundberg\u2019s Foundation, the University of Gothenburg"},{"name":"Medical Training and Clinical Research"},{"name":"Western Go\u00a8taland County Council and the University of Go\u00a8teborg","award":["FoU\/ALFGBG-138661"],"award-info":[{"award-number":["FoU\/ALFGBG-138661"]}]},{"name":"Medical Society of Gothenburg Chair in Rheumatology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Survivin is a proto-oncogene that regulates cell division and apoptosis. It is a molecular marker of cancer. Recently, survivin has emerged as a feature of RA, associated with severe joint damage and poor treatment response. The present study examined if inhibition of survivin affects experimental arthritis, which was induced in mBSA-immunized mice by an injection of mBSA in the knee joint or developed spontaneously in collagen type II-immunized mice. The inhibition of survivin transcription by a lentivirus shRNA construct alleviated joint inflammation and reduced bone damage. The inhibition of survivin reduced the levels of metalloproteinases, \u03b2-catenin, and vimentin, limiting the invasive capacity of synovia, while no inhibition of osteoclastogenesis could be found. The inhibition of survivin led to a p53-independent reduction of T cell proliferation and favored the transcription and activity of Blimp-1, which limited IL-2 production and facilitated formation of regulatory Foxp3+CD4+ and effector CD8+ T cells. The study shows that the inhibition of survivin is sufficient to reduce joint inflammation and bone damage in preclinical models of arthritis. Antiarthritic effects of survivin inhibition are related to p53-independent control of lymphocyte proliferation.<\/jats:p>","DOI":"10.1189\/jlb.3a0714-317r","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T04:04:22Z","timestamp":1415419462000},"page":"135-145","source":"Crossref","is-referenced-by-count":32,"title":["Down-regulation of survivin alleviates experimental arthritis"],"prefix":"10.1093","volume":"97","author":[{"given":"K M E","family":"Andersson","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M N D","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Erlandsson","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-M","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M I","family":"Bokarewa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"2023013012350737800_B1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/acr.21900","article-title":"Incidence of rheumatoid arthritis in Sweden: a nationwide population-based assessment of incidence, its determinants, and treatment penetration","volume":"65","author":"Eriksson","year":"2013","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"2023013012350737800_B2","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar4474","article-title":"Survivin but not Fms-like tyrosine kinase 3 ligand is up-regulated before the onset of rheumatoid arthritis: a pilot study","volume":"16","author":"Bokarewa","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"2023013012350737800_B3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nrc2293","article-title":"Survivin, cancer networks and pathway-directed drug discovery","volume":"8","author":"Altieri","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"2023013012350737800_B4","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/leu.2010.198","article-title":"Overexpression of survivin initiates hematologic malignancies in vivo","volume":"24","author":"Small","year":"2010","journal-title":"Leukemia"},{"key":"2023013012350737800_B5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1158\/1535-7163.MCT-05-0375","article-title":"Survivin, a cancer target with an emerging role in normal adult tissues","volume":"5","author":"Fukuda","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"2023013012350737800_B6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10753-010-9196-1","article-title":"Increased extracellular survivin in the synovial fluid of rheumatoid arthritis patients: fibroblast-like synoviocytes as a potential source of extracellular survivin","volume":"33","author":"Ahn","year":"2010","journal-title":"Inflammation"},{"key":"2023013012350737800_B7","first-page":"881","article-title":"Relationship of angiogenic factors to disease activity and radiographic damage in rheumatoid arthritis","volume":"26","author":"Park","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"2023013012350737800_B8","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/ar2603","article-title":"Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium","volume":"11","author":"Dharmapatni","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"2023013012350737800_B9","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/rheumatology\/kep467","article-title":"Apoptosis in the rheumatoid arthritis synovial membrane: modulation by disease-modifying anti-rheumatic drug treatment","volume":"49","author":"Smith","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"2023013012350737800_B10","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1111\/j.1582-4934.2009.00721.x","article-title":"Survivin is an essential mediator of arthritis interacting with urokinase signalling","volume":"13","author":"Baran","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"2023013012350737800_B11","doi-asserted-by":"crossref","first-page":"R349","DOI":"10.1186\/ar1498","article-title":"Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis","volume":"7","author":"Bokarewa","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"2023013012350737800_B12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/07853890903376280","article-title":"Increased expression of proto-oncogene survivin predicts joint destruction and persistent disease activity in early rheumatoid arthritis","volume":"42","author":"Svensson","year":"2010","journal-title":"Ann. Med."},{"key":"2023013012350737800_B13","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/ar4438","article-title":"Smoking in combination with antibodies to cyclic citrullinated peptides is associated with persistently high levels of survivin in early rheumatoid arthritis: a prospective cohort study","volume":"16","author":"Svensson","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"2023013012350737800_B14","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1182\/blood-2011-03-342428","article-title":"Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells","volume":"119","author":"Singh","year":"2012","journal-title":"Blood"},{"key":"2023013012350737800_B15","doi-asserted-by":"crossref","first-page":"e47668","DOI":"10.1371\/journal.pone.0047668","article-title":"Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis","volume":"7","author":"Andersson","year":"2012","journal-title":"PLoS ONE"},{"key":"2023013012350737800_B16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1084\/jem.20032092","article-title":"Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death","volume":"199","author":"Okada","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023013012350737800_B17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1084\/jem.20031588","article-title":"Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis","volume":"199","author":"Xing","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023013012350737800_B18","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.4049\/jimmunol.180.11.7240","article-title":"Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival","volume":"180","author":"Song","year":"2008","journal-title":"J. Immunol."},{"key":"2023013012350737800_B19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-2478(01)00186-9","article-title":"Survivin expression correlates with apoptosis resistance after lymphocyte activation and is found preferentially in memory T cells","volume":"76","author":"Kornacker","year":"2001","journal-title":"Immunol. Lett."},{"key":"2023013012350737800_B20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/283666a0","article-title":"Immunisation against heterologous type II collagen induces arthritis in mice","volume":"283","author":"Courtenay","year":"1980","journal-title":"Nature"},{"key":"2023013012350737800_B21","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.4049\/jimmunol.118.5.1639","article-title":"Studies on antigen-induced arthritis in mice. II. Immunologic correlates of arthritis susceptibility in mice","volume":"118","author":"Brackertz","year":"1977","journal-title":"J. Immunol."},{"key":"2023013012350737800_B22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1189\/jlb.1110640","article-title":"Inhibition of fms-like tyrosine kinase 3 alleviates experimental arthritis by reducing formation of dendritic cells and antigen presentation","volume":"90","author":"Dehlin","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"2023013012350737800_B23","doi-asserted-by":"crossref","first-page":"R88","DOI":"10.1186\/ar2728","article-title":"Smoking and nicotine exposure delay development of collagen-induced arthritis in mice","volume":"11","author":"Lindblad","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"2023013012350737800_B24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00011-003-1182-8","article-title":"Genistein as an anti-inflammatory agent","volume":"52","author":"Verdrengh","year":"2003","journal-title":"Inflamm. Res."},{"key":"2023013012350737800_B25","doi-asserted-by":"crossref","first-page":"e54884","DOI":"10.1371\/journal.pone.0054884","article-title":"Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune arthritis","volume":"8","author":"Svensson","year":"2013","journal-title":"PLoS ONE"},{"key":"2023013012350737800_B26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/138920108783497659","article-title":"Joint diseases and matrix metalloproteinases: a role for MMP-13","volume":"9","author":"Takaishi","year":"2008","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2023013012350737800_B27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bbrc.2012.03.147","article-title":"Transcriptional inhibition of p21WAF1\/CIP1 gene (CDKN1) expression by survivin is at least partially p53-dependent: evidence for survivin acting as a transcription factor or co-factor","volume":"421","author":"Tang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023013012350737800_B28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev.immunol.26.021607.090241","article-title":"Regulation and functions of Blimp-1 in T and B lymphocytes","volume":"26","author":"Martins","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"2023013012350737800_B29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2009.06.019","article-title":"A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection","volume":"31","author":"Shin","year":"2009","journal-title":"Immunity"},{"key":"2023013012350737800_B30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2009.06.021","article-title":"Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses","volume":"31","author":"Kallies","year":"2009","journal-title":"Immunity"},{"key":"2023013012350737800_B31","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1172\/JCI43758","article-title":"Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice","volume":"121","author":"Khan","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2023013012350737800_B32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/art.1780400206","article-title":"Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity","volume":"40","author":"Tak","year":"1997","journal-title":"Arthritis Rheum."},{"key":"2023013012350737800_B33","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2023013012350737800_B34","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.4049\/jimmunol.1203179","article-title":"Integrin regulation during leukocyte recruitment","volume":"190","author":"Herter","year":"2013","journal-title":"J. Immunol."},{"key":"2023013012350737800_B35","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1002\/art.22217","article-title":"Soluble receptor for advanced glycation end products triggers a proinflammatory cytokine cascade via beta2 integrin Mac-1","volume":"54","author":"Pullerits","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2023013012350737800_B36","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.biopha.2014.01.006","article-title":"Vimentin silencing effect on invasive and migration characteristics of doxorubicin resistant MCF-7 cells","volume":"68","author":"Tezcan","year":"2014","journal-title":"Biomed. Pharmacother."},{"key":"2023013012350737800_B37","doi-asserted-by":"crossref","first-page":"15269","DOI":"10.1074\/jbc.M112.397893","article-title":"Selective inhibition of human group IIA-secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes","volume":"288","author":"Lee","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2023013012350737800_B38","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/nm.2050","article-title":"Synovial fibroblasts spread rheumatoid arthritis to unaffected joints","volume":"15","author":"Lef\u00e8vre","year":"2009","journal-title":"Nat. Med."},{"key":"2023013012350737800_B39","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.4049\/jimmunol.178.4.2483","article-title":"Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium","volume":"178","author":"Zen","year":"2007","journal-title":"J. Immunol."},{"key":"2023013012350737800_B40","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1038\/sj.onc.1208433","article-title":"Differential roles for the coactivators CBP and p300 on TCF\/beta-catenin-mediated survivin gene expression","volume":"24","author":"Ma","year":"2005","journal-title":"Oncogene"},{"key":"2023013012350737800_B41","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrrheum.2013.25","article-title":"To Wnt or not to Wnt: the bone and joint health dilemma","volume":"9","author":"Lories","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"2023013012350737800_B42","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1073\/pnas.050574297","article-title":"Expression and function of wingless and frizzled homologs in rheumatoid arthritis","volume":"97","author":"Sen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013012350737800_B43","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1002\/art.34425","article-title":"A Wnt\/\u03b2-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes","volume":"64","author":"Ma","year":"2012","journal-title":"Arthritis Rheum."},{"key":"2023013012350737800_B44","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1359\/jbmr.090320","article-title":"Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis","volume":"24","author":"Walsh","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"2023013012350737800_B45","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/1529-0131(200104)44:4<772::AID-ANR133>3.0.CO;2-L","article-title":"Blockade of Wnt-5A\/frizzled 5 signaling inhibits rheumatoid synoviocyte activation","volume":"44","author":"Sen","year":"2001","journal-title":"Arthritis Rheum."},{"key":"2023013012350737800_B46","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.devcel.2005.02.013","article-title":"Canonical Wnt\/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes","volume":"8","author":"Hill","year":"2005","journal-title":"Dev. Cell"},{"key":"2023013012350737800_B47","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1210\/me.2009-0379","article-title":"Novel links among Wnt and TGF-beta signaling and Runx2","volume":"24","author":"McCarthy","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"2023013012350737800_B48","doi-asserted-by":"crossref","first-page":"17192","DOI":"10.1073\/pnas.0407788101","article-title":"Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification","volume":"101","author":"Inada","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013012350737800_B49","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1242\/dev.01461","article-title":"Altered endochondral bone development in matrix metalloproteinase 13-deficient mice","volume":"131","author":"Stickens","year":"2004","journal-title":"Development"},{"key":"2023013012350737800_B50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/90100","article-title":"Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome","volume":"28","author":"Martignetti","year":"2001","journal-title":"Nat. Genet."},{"key":"2023013012350737800_B51","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3892\/mmr.2012.755","article-title":"Effects and mechanism of downregulation of survivin expression by RNA interference on proliferation and apoptosis of lung cancer cells","volume":"5","author":"Chen","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"2023013012350737800_B52","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3727\/096504012X13340632812550","article-title":"Gene silence-induced downregulation of survivin inhibits bladder cancer cells","volume":"19","author":"Gou","year":"2011","journal-title":"Oncol. Res."},{"key":"2023013012350737800_B53","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1074\/jbc.M309479200","article-title":"Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis","volume":"279","author":"Beltrami","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023013012350737800_B54","doi-asserted-by":"crossref","first-page":"15100","DOI":"10.1073\/pnas.0406665101","article-title":"Cell division and cell survival in the absence of survivin","volume":"101","author":"Yang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013012350737800_B55","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1182\/blood-2003-05-1756","article-title":"Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1\/Cip1-dependent and -independent pathways","volume":"103","author":"Fukuda","year":"2004","journal-title":"Blood"},{"key":"2023013012350737800_B56","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1093\/emboj\/20.17.4912","article-title":"Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation","volume":"20","author":"Damalas","year":"2001","journal-title":"EMBO J."},{"key":"2023013012350737800_B57","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.immuni.2009.05.014","article-title":"Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties","volume":"31","author":"Rutishauser","year":"2009","journal-title":"Immunity"},{"key":"2023013012350737800_B58","doi-asserted-by":"crossref","first-page":"19078","DOI":"10.1073\/pnas.0907396106","article-title":"Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis","volume":"106","author":"Wright","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013012350737800_B59","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/art.11063","article-title":"CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis","volume":"48","author":"Morgan","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2023013012350737800_B60","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/annrheumdis-2011-201052","article-title":"Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells","volume":"71","author":"Kong","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"2023013012350737800_B61","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1002\/art.27535","article-title":"Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation","volume":"62","author":"Zaiss","year":"2010","journal-title":"Arthritis Rheum."},{"key":"2023013012350737800_B62","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1359\/jbmr.2000.15.8.1477","article-title":"Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts","volume":"15","author":"Takeshita","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"2023013012350737800_B63","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","article-title":"Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction","volume":"203","author":"Sato","year":"2006","journal-title":"J. Exp. Med."},{"key":"2023013012350737800_B64","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/ar2936","article-title":"Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors","volume":"12","author":"Adamopoulos","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"2023013012350737800_B65","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1073\/pnas.0912779107","article-title":"Blimp1-mediated repression of negative regulators is required for osteoclast differentiation","volume":"107","author":"Nishikawa","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013012350737800_B66","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.20091957","article-title":"The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis","volume":"207","author":"Miyauchi","year":"2010","journal-title":"J. Exp. Med."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.3A0714-317R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/97\/1\/135\/48538591\/jlb0135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/97\/1\/135\/48538591\/jlb0135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:32:56Z","timestamp":1677504776000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/97\/1\/135\/6975020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,7]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,11,7]]},"published-print":{"date-parts":[[2015,1,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.3a0714-317r","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,1]]},"published":{"date-parts":[[2014,11,7]]}}}