{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:15Z","timestamp":1791405195364,"version":"4.3.3"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Allergic contact dermatitis (ACD) represents a severe health problem with increasing worldwide prevalence. It is a T-cell-mediated inflammatory skin disease caused by chemicals present in the daily or professional environment. NiSO4 and 2,4-dinitrochlorobenzene (DNCB) are 2 chemicals involved in ACD. These contact sensitizers are known to induce an up-regulation of phenotypic markers and cytokine secretion in dendritic cells (DCs; professional APCs), leading to the generation of CD8+ Tc1\/Tc17 and CD4+ Th1\/Th17 effector T cells. In the present study, using a peptide array approach, we identified protein kinase CK2 as a novel kinase involved in the activation of human monocyte-derived DCs (MoDCs) in response to NiSO4 and DNCB. Inhibition of CK2 activity in MoDCs led to an altered mature phenotype with lower expression of CD54, PDL-1, CD86, and CD40 in response to NiSO4 or DNCB. CK2 activity also regulated proinflammatory cytokine production, such as TNF-\u03b1, IL-1\u03b2, and IL-23 in MoDCs. Moreover, in a DC\/T cell coculture model in an allogeneic setup, CK2 activity in MoDCs played a major role in Th1 polarization in response to NiSO4 and DNCB. CK2 inhibition in MoDCs led to an enhanced Th2 polarization in the absence of contact sensitizer stimulation.<\/jats:p>","DOI":"10.1189\/jlb.3a0715-320rr","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T02:50:13Z","timestamp":1475722213000},"page":"703-715","source":"Crossref","is-referenced-by-count":28,"title":["Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers"],"prefix":"10.1093","volume":"101","author":[{"given":"Marie","family":"de Bourayne","sequence":"first","affiliation":[{"name":"UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Gallais","sequence":"additional","affiliation":[{"name":"UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeina","family":"El Ali","sequence":"additional","affiliation":[{"name":"UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Rousseau","sequence":"additional","affiliation":[{"name":"UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Damiens","sequence":"additional","affiliation":[{"name":"UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Cochet","sequence":"additional","affiliation":[{"name":"Cancer and Infection Biology, UMR1036, INSERM, Institute of Life Sciences Research and Technology (iRTSV), Atomic Energy and Alternative Energy Commission (CEA) , Grenoble , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Filhol","sequence":"additional","affiliation":[{"name":"Cancer and Infection Biology, UMR1036, INSERM, Institute of Life Sciences Research and Technology (iRTSV), Atomic Energy and Alternative Energy Commission (CEA) , Grenoble , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chollet-Martin","sequence":"additional","affiliation":[{"name":"UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pallardy","sequence":"additional","affiliation":[{"name":"UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Kerdine-R\u00f6mer","sequence":"additional","affiliation":[{"name":"UMR996, Inflammation, Chemokines, and Immunopathology, INSERM, University Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"2023011712060397000_B1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00018-011-0846-8","article-title":"Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects: current knowledge assembled at an international workshop at BfR, Germany","volume":"69","author":"Peiser","year":"2012","journal-title":"Cell. 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