{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:43:01Z","timestamp":1793400181602,"version":"4.5.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sj\u00f6gren's syndrome (SS) is an autoimmune disease that often results in diminished exocrine gland function. SS patients also experience systemic disease manifestations, including hypergammaglobulinemia and pulmonary and renal pathoses. MyD88 is a ubiquitously expressed adaptor molecule used by all immune cells that is required for IL-1 receptor (IL-1R), IL-18R, and most TLR signaling. The precise role of MyD88 in SS has not been evaluated, although this adaptor is critical for development of lupus, a related autoimmune disease. This study tested the hypothesis that Myd88-mediated signaling is required for local and systemic SS manifestations. To this end, we generated NOD.B10Sn-H2b\/J (NOD.B10) mice that are deficient in Myd88 (NOD.B10Myd88\u2212\/\u2212). We found that NOD.B10 animals that lack Myd88 show reduced exocrine and extraglandular inflammation. Moreover, these animals are protected from loss of salivary flow. Splenocytes from NOD.B10Myd88\u2212\/\u2212 mice did not up-regulate activation markers or secrete IL-6 in response to a Myd88-dependent agonist, although BCR signaling remained intact. Finally, IgM, IgG, and anti-nuclear autoantibodies were reduced in NOD.B10Myd88\u2212\/\u2212 mice compared with the parental strain. These data demonstrate that Myd88 is a crucial mediator of local and systemic SS disease manifestations.<\/jats:p>","DOI":"10.1189\/jlb.3a0717-311r","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:35:12Z","timestamp":1506472512000},"page":"1411-1420","source":"Crossref","is-referenced-by-count":33,"title":["Myd88 is required for disease development in a primary Sj\u00f6gren's syndrome mouse model"],"prefix":"10.1093","volume":"102","author":[{"given":"Jeremy","family":"Kiripolsky","sequence":"first","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam G","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P","family":"Gaile","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health and Health Professions, University at Buffalo, The State University of New York , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York , Buffalo, New York, USA"},{"name":"Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, The State University of New York , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"2023013012234911700_B1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/acr.21610","article-title":"Primary Sj\u00d6gren's syndrome as a systemic disease: a study of participants enrolled in an international Sj\u00d6gren's syndrome registry","volume":"64","author":"Malladi","year":"2012","journal-title":"Arthritis Care Res. 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