{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:17:30Z","timestamp":1789579050909,"version":"build-2803163510"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY13H090014"],"award-info":[{"award-number":["LY13H090014"]}]},{"name":"Scientific Research Fund of Zhejiang Provincial Education Department","award":["Y201327689"],"award-info":[{"award-number":["Y201327689"]}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo City","doi-asserted-by":"publisher","award":["2013A610205"],"award-info":[{"award-number":["2013A610205"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo City","doi-asserted-by":"publisher","award":["2014A610241"],"award-info":[{"award-number":["2014A610241"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"name":"General Project of Social Development","award":["2013C50054"],"award-info":[{"award-number":["2013C50054"]}]},{"name":"Scientific Innovation Team Project of Ningbo","award":["2011B82014"],"award-info":[{"award-number":["2011B82014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IL-33, a new member of the IL-1F, is widely expressed throughout the body and can be up-regulated by stimulation with proinflammatory factors. It has been identified as a functional ligand for the plasma membrane receptor complex that is a heterodimer consisting of membrane-bound ST2L, which is a member of the IL-1R family, and IL-1RAcP. IL-33 is crucial for the induction of Th2 immune responses. Additionally, under other circumstances, it can also act as an endogenous danger signal. Recently, many studies have demonstrated that IL-33 may be related to the development and progression of fibrotic diseases. It has proinflammatory effects in some fibrotic diseases but has anti-inflammatory effects in others. In this review, the biologic characteristics of IL-33 and the role of the IL-33\/ST2 signaling pathway in various fibrotic diseases will be discussed. We hope this overview will provide new insights for the treatment of these diseases.<\/jats:p>","DOI":"10.1189\/jlb.3ru0115-012r","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T03:01:21Z","timestamp":1429239681000},"page":"15-22","source":"Crossref","is-referenced-by-count":45,"title":["The potential role of IL-33\/ST2 signaling in fibrotic diseases"],"prefix":"10.1093","volume":"98","author":[{"given":"Qiaoyan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Immunology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingcai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine , Ningbo , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"2023013012472814600_B1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"2023013012472814600_B2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1684\/ecn.2011.0288","article-title":"IL-37: a new anti-inflammatory cytokine of the IL-1 family","volume":"22","author":"Boraschi","year":"2011","journal-title":"Eur. 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