{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:20:55Z","timestamp":1793726455566,"version":"4.6.1"},"reference-count":152,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100017540","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Allergy and Infectious Diseases"},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endotoxemia is in its scientific ascendancy. Never has blood-borne, Gram-negative bacterial endotoxin (LPS) been invoked in the pathogenesis of so many diseases\u2014not only as a trigger for septic shock, once its most cited role, but also as a contributor to atherosclerosis, obesity, chronic fatigue, metabolic syndrome, and many other conditions. Finding elevated plasma endotoxin levels has been essential supporting evidence for each of these links, yet the assays used to detect and quantitate endotoxin have important limitations. This article describes several assays for endotoxin in plasma, reviews what they do and do not measure, and discusses why LPS heterogeneity, LPS trafficking pathways, and host LPS inactivation mechanisms should be considered when interpreting endotoxin assay results.<\/jats:p>","DOI":"10.1189\/jlb.3ru0316-151r","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T22:03:44Z","timestamp":1468533824000},"page":"687-698","source":"Crossref","is-referenced-by-count":207,"title":["Endotoxemia\u2014menace, marker, or mistake?"],"prefix":"10.1093","volume":"100","author":[{"given":"Robert S","family":"Munford","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , 9000 Rockville Pike, Bethesda, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"2023011710420720400_B1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1056\/NEJM198908033210503","article-title":"The cardiovascular response of normal humans to the administration of endotoxin","volume":"321","author":"Suffredini","year":"1989","journal-title":"N. Engl. J. Med."},{"issue":"Suppl 7","key":"2023011710420720400_B2","doi-asserted-by":"crossref","first-page":"S470","DOI":"10.1086\/432000","article-title":"Lipopolysaccharide: an endotoxin or an exogenous hormone?","volume":"41","author":"Marshall","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"2023011710420720400_B3","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1128\/JCM.03531-14","article-title":"Endotoxemia as a diagnostic tool for patients with suspected bacteremia caused by gram-negative organisms: a meta-analysis of 4 decades of studies","volume":"53","author":"Hurley","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"2023011710420720400_B4","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1086\/315093","article-title":"Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock","volume":"180","author":"Opal","year":"1999","journal-title":"J. Infect. Dis."},{"key":"2023011710420720400_B5","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0021-9258(19)86166-5","article-title":"The dispersion of gram-negative lipopolysaccharide by deoxycholate. Subunit molecular weight","volume":"255","author":"Shands","year":"1980","journal-title":"J. Biol. Chem."},{"key":"2023011710420720400_B6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nrmicro3525","article-title":"Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions","volume":"13","author":"Schwechheimer","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"2023011710420720400_B7","doi-asserted-by":"crossref","first-page":"14274","DOI":"10.1074\/jbc.M109696200","article-title":"Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice","volume":"277","author":"Hellman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2023011710420720400_B8","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.4049\/jimmunol.143.9.3025","article-title":"Human endothelial cell adhesiveness for neutrophils, induced by Escherichia coli lipopolysaccharide in vitro, is inhibited by Bacteroides fragilis lipopolysaccharide","volume":"143","author":"Magnuson","year":"1989","journal-title":"J. Immunol."},{"key":"2023011710420720400_B9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/IAI.70.1.218-225.2002","article-title":"Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human Toll-like receptor 4","volume":"70","author":"Yoshimura","year":"2002","journal-title":"Infect. 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Med."},{"key":"2023011710420720400_B13","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.4049\/jimmunol.1004087","article-title":"The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo","volume":"187","author":"Lu","year":"2011","journal-title":"J. Immunol."},{"key":"2023011710420720400_B14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0002-9610(86)90098-X","article-title":"Endotoxin: routes of transport in experimental peritonitis","volume":"151","author":"Olofsson","year":"1986","journal-title":"Am. J. Surg."},{"key":"2023011710420720400_B15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1172\/JCI115660","article-title":"Meningococcal endotoxin in lethal septic shock plasma studied by gas chromatography, mass-spectrometry, ultracentrifugation, and electron microscopy","volume":"89","author":"Brandtzaeg","year":"1992","journal-title":"J. Clin. Invest."},{"key":"2023011710420720400_B16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.molmed.2014.08.002","article-title":"Invasive meningococcal disease: a disease of the endothelial cells","volume":"20","author":"Coureuil","year":"2014","journal-title":"Trends Mol. Med."},{"key":"2023011710420720400_B17","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1128\/JCM.42.7.2980-2987.2004","article-title":"Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease","volume":"42","author":"\u00d8vsteb\u00f8","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"2023011710420720400_B18","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1086\/315306","article-title":"Differential antibiotic-induced endotoxin release in severe melioidosis","volume":"181","author":"Simpson","year":"2000","journal-title":"J. Infect. Dis."},{"key":"2023011710420720400_B19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1017\/S0007114510003004","article-title":"The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4","volume":"105","author":"Erridge","year":"2011","journal-title":"Br. J. Nutr."},{"key":"2023011710420720400_B20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1194\/jlr.M800156-JLR200","article-title":"Chylomicrons promote intestinal absorption of lipopolysaccharides","volume":"50","author":"Ghoshal","year":"2009","journal-title":"J. Lipid Res."},{"key":"2023011710420720400_B21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0016-5085(88)90261-2","article-title":"Intestinal endotoxemia. Clinical significance","volume":"94","author":"Van Deventer","year":"1988","journal-title":"Gastroenterology"},{"key":"2023011710420720400_B22","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/ajcn\/86.5.1286","article-title":"A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation","volume":"86","author":"Erridge","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"2023011710420720400_B23","first-page":"223","article-title":"Endotoxins in portal blood","volume":"35","author":"Van Deventer","year":"1988","journal-title":"Hepatogastroenterology"},{"key":"2023011710420720400_B24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2011.02.043","article-title":"Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease","volume":"216","author":"Erridge","year":"2011","journal-title":"Atherosclerosis"},{"key":"2023011710420720400_B25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00005373-199105000-00006","article-title":"Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma","volume":"31","author":"Moore","year":"1991","journal-title":"J. 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Food Sci."},{"key":"2023011710420720400_B34","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.cell.2016.05.056","article-title":"Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans","volume":"165","author":"DIABIMMUNE Study Group","year":"2016","journal-title":"Cell"},{"key":"2023011710420720400_B35","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/clpt.2014.146","article-title":"Human endotoxin administration as an experimental model in drug development","volume":"96","author":"Suffredini","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"2023011710420720400_B36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/0968051907085986","article-title":"From therapy to experimental model: a hundred years of endotoxin administration to human subjects","volume":"13","author":"Bahador","year":"2007","journal-title":"J. Endotoxin Res."},{"key":"2023011710420720400_B37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.pathol.1.110304.100200","article-title":"Severe sepsis and septic shock: the role of gram-negative bacteremia","volume":"1","author":"Munford","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"2023011710420720400_B38","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1086\/315884","article-title":"Detection of circulating lipopolysaccharide-bound monocytes in children with gram-negative sepsis","volume":"182","author":"Takeshita","year":"2000","journal-title":"J. Infect. Dis."},{"key":"2023011710420720400_B39","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1128\/iai.61.8.3209-3215.1993","article-title":"Distribution of bacterial endotoxin in human and rabbit blood and effects of stroma-free hemoglobin","volume":"61","author":"Roth","year":"1993","journal-title":"Infect. Immun."},{"key":"2023011710420720400_B40","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/clinchem\/40.8.1575","article-title":"Endotoxin binding to platelets in blood from patients with a sepsis syndrome","volume":"40","author":"Salden","year":"1994","journal-title":"Clin. Chem."},{"key":"2023011710420720400_B41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood-2005-08-3219","article-title":"Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome","volume":"108","author":"St\u00e5hl","year":"2006","journal-title":"Blood"},{"key":"2023011710420720400_B42","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1097\/01.CCM.0000055366.24147.80","article-title":"Endotoxin binding to erythrocyte membrane and erythrocyte deformability in human sepsis and in vitro","volume":"31","author":"P\u00f6schl","year":"2003","journal-title":"Crit. Care Med."},{"key":"2023011710420720400_B43","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1128\/IAI.68.5.2410-2417.2000","article-title":"Lipopolysaccharide-binding protein and phospholipid transfer protein release lipopolysaccharides from gram-negative bacterial membranes","volume":"68","author":"Vesy","year":"2000","journal-title":"Infect. Immun."},{"key":"2023011710420720400_B44","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1172\/JCI110684","article-title":"Biological activity, lipoprotein-binding behavior, and in vivo disposition of extracted and native forms of Salmonella typhimurium lipopolysaccharides","volume":"70","author":"Munford","year":"1982","journal-title":"J. Clin. Invest."},{"key":"2023011710420720400_B45","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1128\/IAI.69.5.2821-2828.2001","article-title":"Distribution and kinetics of lipoprotein-bound endotoxin","volume":"69","author":"Levels","year":"2001","journal-title":"Infect. Immun."},{"key":"2023011710420720400_B46","first-page":"151","article-title":"The effect of cell-free hemoglobin on intravascular clearance and cellular, plasma, and organ distribution of bacterial endotoxin in rabbits","volume":"126","author":"Yoshida","year":"1995","journal-title":"J. Lab. Clin. Med."},{"key":"2023011710420720400_B47","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1172\/JCI110404","article-title":"Sites of tissue binding and uptake in vivo of bacterial lipopolysaccharide-high density lipoprotein complexes: studies in the rat and squirrel monkey","volume":"68","author":"Munford","year":"1981","journal-title":"J. Clin. Invest."},{"key":"2023011710420720400_B48","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/1753425912442431","article-title":"Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes","volume":"18","author":"Shao","year":"2012","journal-title":"Innate Immun."},{"key":"2023011710420720400_B49","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/gut.19.10.935","article-title":"Portal and systemic bacteraemia and endotoxaemia in liver disease","volume":"19","author":"Triger","year":"1978","journal-title":"Gut"},{"key":"2023011710420720400_B50","first-page":"73","article-title":"Collaborative study for the establishment of the WHO 3(rd) International Standard for Endotoxin, the Ph. Eur. endotoxin biological reference preparation batch 5 and the USP Reference Standard for Endotoxin Lot H0K354","volume":"2015","author":"Findlay","year":"2015","journal-title":"Pharmeur. Bio. Sci. Notes"},{"key":"2023011710420720400_B51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biochi.2015.06.020","article-title":"Metabolic endotoxemia with obesity: Is it real and is it relevant?","volume":"124","author":"Boutagy","year":"2016","journal-title":"Biochimie"},{"key":"2023011710420720400_B52","first-page":"903","article-title":"Detection of endotoxin in human blood and demonstration of an inhibitor","volume":"75","author":"Levin","year":"1970","journal-title":"J. Lab. Clin. Med."},{"key":"2023011710420720400_B53","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/0968051907078604","article-title":"Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors","volume":"13","author":"Tsan","year":"2007","journal-title":"J. Endotoxin Res."},{"key":"2023011710420720400_B54","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1189\/jlb.1209775","article-title":"Endogenous ligands of TLR2 and TLR4: agonists or assistants?","volume":"87","author":"Erridge","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"2023011710420720400_B55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/10408363.2015.1123215","article-title":"Chasing a ghost?\u2014Issues with the determination of circulating levels of endotoxin in human blood","volume":"53","author":"Gnauck","year":"2016","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"2023011710420720400_B56","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1056\/NEJM197012102832404","article-title":"Detection of endotoxin in the blood of patients with sepsis due to gran-negative bacteria","volume":"283","author":"Levin","year":"1970","journal-title":"N. Engl. J. Med."},{"key":"2023011710420720400_B57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0165-022X(91)90022-O","article-title":"A novel endotoxin-specific assay by turbidimetry with Limulus amoebocyte lysate containing beta-glucan","volume":"22","author":"Kambayashi","year":"1991","journal-title":"J. Biochem. Biophys. Methods"},{"key":"2023011710420720400_B58","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-90-481-9078-2_9","article-title":"Endotoxin detection\u2014from Limulus amebocyte lysate to recombinant factor C","volume":"53","author":"Ding","year":"2010","journal-title":"Subcell. Biochem."},{"key":"2023011710420720400_B59","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jim.2014.11.010","article-title":"The Limulus amebocyte lysate assay may be unsuitable for detecting endotoxin in blood of healthy female subjects","volume":"416","author":"Gnauck","year":"2015","journal-title":"J. Immunol. 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Endotoxin Res."},{"key":"2023011710420720400_B65","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/1043-4666(90)90025-O","article-title":"Dissociation between the interleukin 1-inducing capacity and Limulus reactivity of lipopolysaccharides from gram-negative bacteria","volume":"2","author":"Laude-Sharp","year":"1990","journal-title":"Cytokine"},{"key":"2023011710420720400_B66","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1128\/iai.59.6.1881-1887.1991","article-title":"Enzymatically deacylated Neisseria lipopolysaccharide (LPS) inhibits murine splenocyte mitogenesis induced by LPS","volume":"59","author":"Erwin","year":"1991","journal-title":"Infect. 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Dis."},{"key":"2023011710420720400_B70","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1001\/archinte.1978.03630270047018","article-title":"Typhoid fever. Studies of blood coagulation, bacteremia, and endotoxemia","volume":"138","author":"Butler","year":"1978","journal-title":"Arch. Intern. Med."},{"key":"2023011710420720400_B71","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000321622","article-title":"Low endotoxin release from Escherichia coli and Bacteroides \u00a0fragilis during exposure to moxifloxacin","volume":"56","author":"Trautmann","year":"2010","journal-title":"Chemotherapy"},{"key":"2023011710420720400_B72","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1128\/IAI.74.5.2809-2816.2006","article-title":"Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS","volume":"74","author":"Katz","year":"2006","journal-title":"Infect. 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Chem."},{"key":"2023011710420720400_B120","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1084\/jem.176.2.485","article-title":"Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway","volume":"176","author":"Kitchens","year":"1992","journal-title":"J. Exp. Med."},{"key":"2023011710420720400_B121","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1086\/515348","article-title":"Lymph of patients with a systemic inflammatory response syndrome inhibits lipopolysaccharide-induced cytokine production","volume":"178","author":"Lemaire","year":"1998","journal-title":"J. Infect. Dis."},{"key":"2023011710420720400_B122","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1128\/iai.57.6.1786-1791.1989","article-title":"Retention of bacterial lipopolysaccharide at the site of subcutaneous injection","volume":"57","author":"Yokochi","year":"1989","journal-title":"Infect. 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Invest."},{"key":"2023011710420720400_B127","doi-asserted-by":"crossref","first-page":"34116","DOI":"10.1074\/jbc.274.48.34116","article-title":"Plasma lipoproteins promote the release of bacterial lipopolysaccharide from the monocyte cell surface","volume":"274","author":"Kitchens","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2023011710420720400_B128","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1128\/CDLI.6.6.844-850.1999","article-title":"Changes in endotoxin-binding proteins during major elective surgery: important role for soluble CD14 in regulation of biological activity of systemic endotoxin","volume":"6","author":"Hiki","year":"1999","journal-title":"Clin. Diagn. Lab. 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Chem."},{"key":"2023011710420720400_B130","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S1286-4579(00)01271-5","article-title":"Mechanisms of disposal of bacterial lipopolysaccharides by animal hosts","volume":"2","author":"Elsbach","year":"2000","journal-title":"Microbes Infect."},{"key":"2023011710420720400_B131","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0171-2985(11)80354-2","article-title":"The bactericidal\/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide","volume":"187","author":"Elsbach","year":"1993","journal-title":"Immunobiology"},{"key":"2023011710420720400_B132","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.4049\/jimmunol.151.8.4258","article-title":"Antagonistic effects of lipopolysaccharide binding protein and bactericidal\/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. 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Immunol."},{"key":"2023011710420720400_B137","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1084\/jem.184.1.51","article-title":"Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes","volume":"184","author":"Brandtzaeg","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023011710420720400_B138","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/1753425914547743","article-title":"IL-10 immunodepletion from meningococcal sepsis plasma induces extensive changes in gene expression and cytokine release in stimulated human monocytes","volume":"21","author":"Gopinathan","year":"2015","journal-title":"Innate Immun."},{"key":"2023011710420720400_B139","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1615\/CritRevImmunol.2015015495","article-title":"The regulation of endotoxin tolerance and its impact on macrophage activation","volume":"35","author":"Collins","year":"2015","journal-title":"Crit. Rev. Immunol."},{"key":"2023011710420720400_B140","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1182\/blood.V91.9.3439","article-title":"Reduced ex vivo interleukin-8 production by neutrophils in septic and nonseptic systemic inflammatory response syndrome","volume":"91","author":"Marie","year":"1998","journal-title":"Blood"},{"key":"2023011710420720400_B141","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1189\/jlb.4A0415-168RR","article-title":"Marked alterations of neutrophil functions during sepsis-induced immunosuppression","volume":"98","author":"Demaret","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"2023011710420720400_B142","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1097\/01.CCM.0000063260.07222.76","article-title":"Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure","volume":"31","author":"Levels","year":"2003","journal-title":"Crit. Care Med."},{"key":"2023011710420720400_B143","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1194\/jlr.M300228-JLR200","article-title":"Acute inflammation and infection maintain circulating phospholipid levels and enhance lipopolysaccharide binding to plasma lipoproteins","volume":"44","author":"Kitchens","year":"2003","journal-title":"J. Lipid Res."},{"key":"2023011710420720400_B144","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/infdis\/171.5.1250","article-title":"Lipopolysaccharide toxicity-regulating proteins in bacteremia","volume":"171","author":"Froon","year":"1995","journal-title":"J. Infect. Dis."},{"key":"2023011710420720400_B145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1128\/IAI.73.1.193-200.2005","article-title":"Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms","volume":"73","author":"Hamann","year":"2005","journal-title":"Infect. Immun."},{"key":"2023011710420720400_B146","doi-asserted-by":"crossref","first-page":"28367","DOI":"10.1074\/jbc.M302921200","article-title":"Lipopolysaccharide (LPS)-binding protein inhibits responses to cell-bound LPS","volume":"278","author":"Thompson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2023011710420720400_B147","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1172\/JCI113359","article-title":"Low density lipoproteins transfer bacterial lipopolysaccharides across endothelial monolayers in a biologically active form","volume":"81","author":"Navab","year":"1988","journal-title":"J. Clin. Invest."},{"key":"2023011710420720400_B148","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/emmm.201100159","article-title":"Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment","volume":"3","author":"Amar","year":"2011","journal-title":"EMBO Mol. 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