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Pulmonary manifestations reported in inflammatory bowel disease include bronchiectasis, chronic bronchitis and importantly, a range of subclinical respiratory abnormalities that are often overlooked in routine clinical evaluation. Whereas evidence for the pulmonary manifestations of Inflammatory bowel disease is increasing, little is known about the immunologic and physiologic mechanisms regulating cross-talk between the gut and lung during disease. This review examines reported lung involvement in Inflammatory bowel disease and discusses the possible immune pathways that underlie pulmonary pathologies. These mechanisms include dysfunctional immune-cell homing, systemic inflammation, and microbial dysbiosis; all of which may contribute to Inflammatory bowel disease-induced pulmonary inflammation. These mechanisms are discussed in the context of our current knowledge of the shared mucosal immune system and the immunology of Inflammatory bowel disease.<\/jats:p>","DOI":"10.1189\/jlb.3ru1114-563r","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T01:24:19Z","timestamp":1440552259000},"page":"727-737","source":"Crossref","is-referenced-by-count":53,"title":["Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease"],"prefix":"10.1093","volume":"98","author":[{"given":"Sean W","family":"Mateer","sequence":"first","affiliation":[{"name":"Gastrointestinal Research Group, Viruses, Infection\/Immunity, Vaccines and Asthma Program, and, Callaghan , New South Wales , Australia"},{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Maltby","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan , New South Wales , Australia"},{"name":"Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, New Lambton Heights , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Marks","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Group, Viruses, Infection\/Immunity, Vaccines and Asthma Program, and, Callaghan , New South Wales , Australia"},{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S","family":"Foster","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan , New South Wales , Australia"},{"name":"Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, New Lambton Heights , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay C","family":"Horvat","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan , New South Wales , Australia"},{"name":"Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, New Lambton Heights , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M","family":"Hansbro","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan , New South Wales , Australia"},{"name":"Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, New Lambton Heights , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Keely","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Group, Viruses, Infection\/Immunity, Vaccines and Asthma Program, and, Callaghan , New South Wales , Australia"},{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"2023013012475826700_B1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.suc.2007.03.001","article-title":"Pathophysiology of inflammatory bowel disease: an overview","volume":"87","author":"Thoreson","year":"2007","journal-title":"Surg. 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