{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T05:13:04Z","timestamp":1774069984874,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA019568"],"award-info":[{"award-number":["R01 AA019568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Carver College of Medicine Department of Pathology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alcoholics are at increased risk of Staphylococcus aureus skin infection and serious sequelae, such as bacteremia and death. Despite the association between alcoholism and severe S. aureus skin infection, the impact of EtOH on anti-S. aureus cutaneous immunity has not been investigated in a model of chronic EtOH exposure. To test the hypothesis that EtOH enhances the severity of S. aureus skin infection, mice were fed EtOH for \u226512 weeks via the Meadows-Cook model of alcoholism and inoculated with S. aureus following epidermal abrasion. Evidence of exacerbated staphylococcal disease in EtOH-fed mice included: skin lesions that were larger and contained more organisms, greater weight loss, and increased bacterial dissemination. Infected EtOH-fed mice demonstrated poor maintenance and induction of PMN responses in skin and draining LNs, respectively. Additionally, altered PMN dynamics in the skin of these mice corresponded with reduced production of IL-23 and IL-1\u03b2 by CD11b+ myeloid cells and IL-17 production by \u03b3\u03b4 T cells, with the latter defect occurring in the draining LNs as well. In addition, IL-17 restoration attenuated S. aureus-induced dermatopathology and improved bacterial clearance defects in EtOH-fed mice. Taken together, the findings show, in a novel model system, that the EtOH-induced increase in S. aureus-related injury\/illness corresponds with defects in the IL-23\/IL-17 inflammatory axis and poor PMN accumulation at the site of infection and draining LNs. These findings offer new information about the impact of EtOH on cutaneous host-defense pathways and provide a potential mechanism explaining why alcoholics are predisposed to S. aureus skin infection.<\/jats:p>","DOI":"10.1189\/jlb.4a0214-092r","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T03:47:48Z","timestamp":1421812068000},"page":"769-778","source":"Crossref","is-referenced-by-count":19,"title":["Chronic ethanol feeding increases the severity of <i>Staphylococcus aureus<\/i> skin infections by altering local host defenses"],"prefix":"10.1093","volume":"97","author":[{"given":"Corey P","family":"Parlet","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Iowa Carver College of Medicine , Iowa City, Iowa , USA"},{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S","family":"Kavanaugh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa Carver College of Medicine , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander R","family":"Horswill","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa Carver College of Medicine , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette J","family":"Schlueter","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa Carver College of Medicine , Iowa City, Iowa , USA"},{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"2023013012470881700_B1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1086\/526773","article-title":"Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection","volume":"46","author":"Miller","year":"2008","journal-title":"Clin. 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