{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:55:25Z","timestamp":1776876925873,"version":"3.51.2"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Shriners of North America","award":["#87900"],"award-info":[{"award-number":["#87900"]}]},{"name":"Shriners of North America","award":["#80500"],"award-info":[{"award-number":["#80500"]}]},{"name":"Shriners of North America","award":["#80100"],"award-info":[{"award-number":["#80100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gut microbiota that invades to the defective mucosal barrier is one of the major sources of infectious complications in severely burned hosts. In this study, a role of group 2 innate lymphoid cells (ILC2) and effects of N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-2-thiophenesulfonamide (SR3335) on the host antibacterial resistance against infectious complications caused by Enterococcus faecalis oral infection were investigated in burned mice. Retinoic acid receptor-related orphan receptor \u03b1 (ROR\u03b1) is a transcription factor required for the development of ILC2, and SR3335 is an ROR\u03b1-selective inverse agonist. All of burned mice died within 6 d of E. faecalis infection (5 \u00d7 106 CFU\/mouse), whereas 100% of the same mice treated with SR3335 survived. The increased ILC2 and their cytokine products (IL-5 and IL-13) were detected in the lamina propria of mice, 1\u20137 d after burn injury. However, the number of ILC2 did not increase in the lamina propria of burned mice treated with SR3335. The antibacterial resistance of SCID-beige (SCIDbg) mice to E. faecalis infection was impaired by the inoculation of ILC2. BALB\/c, SCIDbg, and polymorphonuclear leukocyte (PMN)-depleted SCIDbg mice were shown to be resistant against E. faecalis infection. However, all M\u03d5 depleted SCIDbg mice died after the infection. These results indicate that host antibacterial effector M\u03d5 against enterococcal translocation are influenced by ILC2, increased in the bacterial translocation site of burned mice, and sepsis stemming from E. faecalis oral infection was amazingly mitigated in these mice after treatment with SR3335, an inhibitor of cellular differentiation from an ILC precursor (ILCP) to ILC2.<\/jats:p>","DOI":"10.1189\/jlb.4a0517-195r","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:35:12Z","timestamp":1506472512000},"page":"1451-1460","source":"Crossref","is-referenced-by-count":7,"title":["Lamina propria group 2 innate lymphoid cells impair the antibacterial defense of burned mice to enterococcal translocation"],"prefix":"10.1093","volume":"102","author":[{"given":"Ichiaki","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas, USA"},{"name":"Shriners Hospitals for Children , Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamlesh K","family":"Bhopale","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas, USA"},{"name":"Shriners Hospitals for Children , Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste C","family":"Finnerty","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children , Galveston, Texas, USA"},{"name":"Department of Surgery, The University of Texas Medical Branch , Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N","family":"Herndon","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children , Galveston, Texas, USA"},{"name":"Department of Surgery, The University of Texas Medical Branch , Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas, USA"},{"name":"Shriners Hospitals for Children , Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"2023013012235122600_B1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1089\/sur.2013.134","article-title":"Infection in burns","volume":"17","author":"Norbury","year":"2016","journal-title":"Surg. 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