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However, no exhaustive study has been done to identify the genes and proteins of eosinophils involved in the pathogenesis of tropical pulmonary eosinophilia. In the present study, we established a mouse model of tropical pulmonary eosinophilia that mimicked filarial manifestations of human tropical pulmonary eosinophilia pathogenesis and used flow cytometry-assisted cell sorting and real-time RT-PCR to study the gene expression profile of flow-sorted, lung eosinophils and lung macrophages during tropical pulmonary eosinophilia pathogenesis. Our results show that tropical pulmonary eosinophilia mice exhibited increased levels of IL-4, IL-5, CCL5, and CCL11 in the bronchoalveolar lavage fluid and lung parenchyma along with elevated titers of IgE and IgG subtypes in the serum. Alveolar macrophages from tropical pulmonary eosinophilia mice displayed decreased phagocytosis, attenuated nitric oxide production, and reduced T-cell proliferation capacity, and FACS-sorted lung eosinophils from tropical pulmonary eosinophilia mice upregulated transcript levels of ficolin A and anti-apoptotic gene Bcl2, but proapoptotic genes Bim and Bax were downregulated. Similarly, flow-sorted lung macrophages upregulated transcript levels of TLR-2, TLR-6, arginase-1, Ym-1, and FIZZ-1 but downregulated nitric oxide synthase-2 levels, signifying their alternative activation. Taken together, we show that the pathogenesis of tropical pulmonary eosinophilia is marked by functional impairment of alveolar macrophages, alternative activation of lung macrophages, and upregulation of anti-apoptotic genes by eosinophils. These events combine together to cause severe lung inflammation and compromised lung immunity. Therapeutic interventions that can boost host immune response in the lungs might thus provide relief to patients with tropical pulmonary eosinophilia.<\/jats:p>","DOI":"10.1189\/jlb.4a0715-309rr","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T03:14:30Z","timestamp":1445483670000},"page":"619-628","source":"Crossref","is-referenced-by-count":21,"title":["Host lung immunity is severely compromised during tropical pulmonary eosinophilia: role of lung eosinophils and macrophages"],"prefix":"10.1093","volume":"99","author":[{"given":"Pankaj","family":"Sharma","sequence":"first","affiliation":[{"name":"Parasitology Division , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Parasitology Division , New Delhi , India"},{"name":"Academy of Scientific and Innovative Research , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achchhe Lal","family":"Vishwakarma","sequence":"additional","affiliation":[{"name":"Sophisticated Analytical Instrument Facility , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Promod Kumar","family":"Agnihotri","sequence":"additional","affiliation":[{"name":"Toxicology Division, Council of Scientific and Industrial Research\u2013Central Drug Research Institute , Lucknow , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad","family":"Sharma","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research , New Delhi , India"},{"name":"Toxicology Division, Council of Scientific and Industrial Research\u2013Central Drug Research Institute , Lucknow , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrigank","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Parasitology Division , New Delhi , India"},{"name":"Academy of Scientific and Innovative Research , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,21]]},"reference":[{"key":"2023013012483879200_B1","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1378\/chest.113.6.1673","article-title":"Tropical pulmonary eosinophilia","volume":"113","author":"Ong","year":"1998","journal-title":"Chest"},{"key":"2023013012483879200_B2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1086\/423964","article-title":"Tropical pulmonary eosinophilia: a case series in a setting of nonendemicity","volume":"39","author":"Boggild","year":"2004","journal-title":"Clin. 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