{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:37:34Z","timestamp":1790534254028,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL065095"],"award-info":[{"award-number":["R01HL065095"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIH National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["5R01AI092084"],"award-info":[{"award-number":["5R01AI092084"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIH National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["5R01AI097519"],"award-info":[{"award-number":["5R01AI097519"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIH National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["1K08AI110655"],"award-info":[{"award-number":["1K08AI110655"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302529"],"award-info":[{"award-number":["81302529"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Fujian, China","award":["2014D007"],"award-info":[{"award-number":["2014D007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The C-type lectin receptor dectin-1 and the integrin Mac-1 have key roles in controlling fungal infection. Here, we demonstrate that dectin-1- and Mac-1-induced activation of protein kinase C\u03b4 in neutrophils, independent of the Card9 adaptor, is required for reactive oxygen species production and for intracellular killing upon Candida albicans uptake. Protein kinase C\u03b4 was also required for zymosan-induced cytokine generation in neutrophils. In macrophages, protein kinase C\u03b4 deficiency prevented fungi-induced reactive oxygen species generation but had no effect on activation of TGF-\u03b2-activated kinase-1, an effector of Card9, or nuclear factor \u03baB activation, nor did it affect phagolysosomal maturation, autophagy, or intracellular C. albicans killing. In vivo, protein kinase C\u03b4\u2013deficient mice were highly susceptible to C. albicans and Aspergillus fumigatus infection, which was partially rescued with adoptively transferred wild-type neutrophils. Thus, protein kinase C\u03b4 activation downstream of dectin-1 and Mac-1 has an important role in neutrophil, but not macrophage, functions required for host defense against fungal pathogens.<\/jats:p>","DOI":"10.1189\/jlb.4a0915-405r","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T04:49:32Z","timestamp":1457671772000},"page":"581-588","source":"Crossref","is-referenced-by-count":29,"title":["PKC-\u03b4 activation in neutrophils promotes fungal clearance"],"prefix":"10.1093","volume":"100","author":[{"given":"Xun","family":"Li","sequence":"first","affiliation":[{"name":"Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, Massachusetts , USA"},{"name":"Department of Laboratory Medicine, The First Affiliated Hospital, Medical College of Xiamen University , Xiamen, Fujian , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Cullere","sequence":"additional","affiliation":[{"name":"Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nishi","sequence":"additional","affiliation":[{"name":"Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpanna","family":"Saggu","sequence":"additional","affiliation":[{"name":"Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Durand","sequence":"additional","affiliation":[{"name":"Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny M","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-yu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital, Medical College of Xiamen University , Xiamen, Fujian , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center , Houston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin M","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Mayadas","sequence":"additional","affiliation":[{"name":"Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"2023011710415155400_B1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrmicro1426","article-title":"Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus","volume":"4","author":"Chauhan","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"2023011710415155400_B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-030409-101229","article-title":"Innate antifungal immunity: the key role of phagocytes","volume":"29","author":"Brown","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"2023011710415155400_B3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0952-7915(03)00109-2","article-title":"Chronic granulomatous disease","volume":"15","author":"Heyworth","year":"2003","journal-title":"Curr. Opin. Immunol."},{"key":"2023011710415155400_B4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/416291a","article-title":"Killing activity of neutrophils is mediated through activation of proteases by K+ flux","volume":"416","author":"Reeves","year":"2002","journal-title":"Nature"},{"key":"2023011710415155400_B5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1074-7613(00)80173-9","article-title":"Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G","volume":"12","author":"Tkalcevic","year":"2000","journal-title":"Immunity"},{"key":"2023011710415155400_B6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12281-011-0076-4","article-title":"Genetic susceptibility to fungal infections in humans","volume":"6","author":"Lionakis","year":"2012","journal-title":"Curr. Fungal Infect. Rep."},{"key":"2023011710415155400_B7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrmicro1815","article-title":"An integrated model of the recognition of Candida albicans by the innate immune system","volume":"6","author":"Netea","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"2023011710415155400_B8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1084\/jem.20020470","article-title":"Dectin-1 is a major \u03b2-glucan receptor on macrophages","volume":"196","author":"Brown","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023011710415155400_B9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ni1408","article-title":"Dectin-1 is required for \u03b2-glucan recognition and control of fungal infection","volume":"8","author":"Taylor","year":"2007","journal-title":"Nat. Immunol."},{"key":"2023011710415155400_B10","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1084\/jem.20021787","article-title":"Collaborative induction of inflammatory responses by Dectin-1 and Toll-like receptor 2","volume":"197","author":"Gantner","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023011710415155400_B11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.chom.2011.10.009","article-title":"The \u03b2-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance","volume":"10","author":"Li","year":"2011","journal-title":"Cell Host Microbe"},{"key":"2023011710415155400_B12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"2023011710415155400_B13","doi-asserted-by":"crossref","first-page":"8667","DOI":"10.4049\/jimmunol.177.12.8667","article-title":"\u03b2-Glucan is a fungal determinant for adhesion-dependent human neutrophil functions","volume":"177","author":"Lavigne","year":"2006","journal-title":"J. Immunol."},{"key":"2023011710415155400_B14","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.4049\/jimmunol.1202671","article-title":"An extracellular matrix-based mechanism of rapid neutrophil extracellular trap formation in response to Candida albicans","volume":"190","author":"Byrd","year":"2013","journal-title":"J. Immunol."},{"key":"2023011710415155400_B15","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/sj.emboj.7600594","article-title":"Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments","volume":"24","author":"Gantner","year":"2005","journal-title":"EMBO J."},{"key":"2023011710415155400_B16","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1128\/IAI.00650-10","article-title":"Regulation of innate immune response to Candida albicans infections by \u03b1M\u03b22-Pra1p interaction","volume":"79","author":"Soloviev","year":"2011","journal-title":"Infect. Immun."},{"key":"2023011710415155400_B17","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ni.2987","article-title":"Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens","volume":"15","author":"Branzk","year":"2014","journal-title":"Nat. Immunol."},{"key":"2023011710415155400_B18","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1182\/blood-2014-01-551473","article-title":"Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects","volume":"124","author":"Gazendam","year":"2014","journal-title":"Blood"},{"key":"2023011710415155400_B19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.coi.2011.12.010","article-title":"Role of ITAM signaling module in signal integration","volume":"24","author":"Bezbradica","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"2023011710415155400_B20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/intimm\/dxr046","article-title":"Dectin-1 and Dectin-2 in innate immunity against fungi","volume":"23","author":"Saijo","year":"2011","journal-title":"Int. Immunol."},{"key":"2023011710415155400_B21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.it.2013.02.006","article-title":"Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation","volume":"34","author":"Roth","year":"2013","journal-title":"Trends Immunol."},{"key":"2023011710415155400_B22","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1182\/blood-2012-08-450551","article-title":"Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency","volume":"121","author":"Drewniak","year":"2013","journal-title":"Blood"},{"key":"2023011710415155400_B23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2011.11.015","article-title":"Syk kinase-coupled C-type lectin receptors engage protein kinase C-s to elicit Card9 adaptor-mediated innate immunity","volume":"36","author":"Strasser","year":"2012","journal-title":"Immunity"},{"key":"2023011710415155400_B24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature04926","article-title":"Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity","volume":"442","author":"Gross","year":"2006","journal-title":"Nature"},{"key":"2023011710415155400_B25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1172\/JCI200421655","article-title":"Neutrophil protein kinase C\u03b4 as a mediator of stroke-reperfusion injury","volume":"114","author":"Chou","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2023011710415155400_B26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/ni1425","article-title":"Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans","volume":"8","author":"Saijo","year":"2007","journal-title":"Nat. Immunol."},{"key":"2023011710415155400_B27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ni1426","article-title":"The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens","volume":"8","author":"Hsu","year":"2007","journal-title":"Nat. Immunol."},{"key":"2023011710415155400_B28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.immuni.2006.05.014","article-title":"Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy","volume":"25","author":"Hirahashi","year":"2006","journal-title":"Immunity"},{"key":"2023011710415155400_B29","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nature06607","article-title":"Regulation of progenitor cell proliferation and granulocyte function by microRNA-223","volume":"451","author":"Johnnidis","year":"2008","journal-title":"Nature"},{"key":"2023011710415155400_B30","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1086\/422329","article-title":"Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice","volume":"190","author":"Huang","year":"2004","journal-title":"J. Infect. Dis."},{"key":"2023011710415155400_B31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature05380","article-title":"A systems biology analysis of the Drosophila phagosome","volume":"445","author":"Stuart","year":"2007","journal-title":"Nature"},{"key":"2023011710415155400_B32","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1074\/jbc.M113.473223","article-title":"Dectin-1 activation controls maturation of \u03b2-1,3-glucan-containing phagosomes","volume":"288","author":"Mansour","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2023011710415155400_B33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1039\/C2IB00089J","article-title":"Use of fungal derived polysaccharide-conjugated particles to probe Dectin-1 responses in innate immunity","volume":"4","author":"Tam","year":"2012","journal-title":"Integr. Biol. (Camb.)"},{"key":"2023011710415155400_B34","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.127.3301.756-b","article-title":"On the composition of zymosan","volume":"127","author":"Di Carlo","year":"1958","journal-title":"Science"},{"key":"2023011710415155400_B35","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1182\/blood-2010-08-300889","article-title":"Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase","volume":"116","author":"Chessa","year":"2010","journal-title":"Blood"},{"key":"2023011710415155400_B36","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1182\/blood-2009-07-231498","article-title":"A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity","volume":"114","author":"Matute","year":"2009","journal-title":"Blood"},{"key":"2023011710415155400_B37","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1084\/jem.20052069","article-title":"Neutrophils from p40phox-\/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing","volume":"203","author":"Ellson","year":"2006","journal-title":"J. Exp. Med."},{"key":"2023011710415155400_B38","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.4049\/jimmunol.173.9.5730","article-title":"Protein kinase C\u03b4 is required for p47phox phosphorylation and translocation in activated human monocytes","volume":"173","author":"Bey","year":"2004","journal-title":"J. Immunol."},{"key":"2023011710415155400_B39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/jb\/mvn142","article-title":"Negative regulation of class IA phosphoinositide 3-kinase by protein kinase C\u03b4 limits Fc\u03b3 receptor-mediated phagocytosis in macrophages","volume":"145","author":"Hazeki","year":"2009","journal-title":"J. Biochem."},{"key":"2023011710415155400_B40","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1074\/jbc.M512167200","article-title":"Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2023011710415155400_B41","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1093\/infdis\/jiu290","article-title":"Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages","volume":"210","author":"Tam","year":"2014","journal-title":"J. Infect. Dis."},{"key":"2023011710415155400_B42","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.4049\/jimmunol.180.10.6854","article-title":"Reduced nicotinamide adenine dinucleotide phosphate oxidase-independent resistance to Aspergillus fumigatus in alveolar macrophages","volume":"180","author":"Cornish","year":"2008","journal-title":"J. Immunol."},{"key":"2023011710415155400_B43","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1086\/600380","article-title":"Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection","volume":"200","author":"Mircescu","year":"2009","journal-title":"J. Infect. Dis."},{"key":"2023011710415155400_B44","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1128\/IAI.00909-06","article-title":"Early neutrophil recruitment and aggregation in the murine lung inhibit germination of Aspergillus fumigatus conidia","volume":"74","author":"Bonnett","year":"2006","journal-title":"Infect. Immun."},{"key":"2023011710415155400_B45","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.4049\/jimmunol.1202800","article-title":"Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice","volume":"190","author":"Grimm","year":"2013","journal-title":"J. Immunol."},{"key":"2023011710415155400_B46","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1128\/IAI.71.6.3034-3042.2003","article-title":"Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates","volume":"71","author":"Philippe","year":"2003","journal-title":"Infect. Immun."},{"key":"2023011710415155400_B47","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4049\/jimmunol.182.2.1146","article-title":"Differential use of CARD9 by dectin-1 in macrophages and dendritic cells","volume":"182","author":"Goodridge","year":"2009","journal-title":"J. Immunol."},{"key":"2023011710415155400_B48","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/ni.1788","article-title":"CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex","volume":"10","author":"Wu","year":"2009","journal-title":"Nat. Immunol."},{"key":"2023011710415155400_B49","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1056\/NEJMoa0810719","article-title":"A homozygous CARD9 mutation in a family with susceptibility to fungal infections","volume":"361","author":"Glocker","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2023011710415155400_B50","doi-asserted-by":"crossref","first-page":"e1004589","DOI":"10.1371\/journal.ppat.1004589","article-title":"Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection","volume":"11","author":"Jhingran","year":"2015","journal-title":"PLoS Pathog."},{"key":"2023011710415155400_B51","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.191.10.1661","article-title":"Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo","volume":"191","author":"D\u2019Ostiani","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023011710415155400_B52","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1128\/IAI.73.11.7458-7464.2005","article-title":"Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae","volume":"73","author":"van der Graaf","year":"2005","journal-title":"Infect. Immun."},{"key":"2023011710415155400_B53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1369-5274(02)00338-7","article-title":"Fungal morphogenesis and host invasion","volume":"5","author":"Gow","year":"2002","journal-title":"Curr. Opin. Microbiol."},{"key":"2023011710415155400_B54","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/ng.605","article-title":"Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity","volume":"42","author":"Noble","year":"2010","journal-title":"Nat. Genet."},{"key":"2023011710415155400_B55","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1128\/MMBR.00009-06","article-title":"Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans","volume":"71","author":"Biswas","year":"2007","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"2023011710415155400_B56","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.chom.2009.03.006","article-title":"Antifungal innate immunity in C. elegans: PKC\u03b4 links G protein signaling and a conserved p38 MAPK cascade","volume":"5","author":"Ziegler","year":"2009","journal-title":"Cell Host Microbe"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.4A0915-405R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/100\/3\/581\/48716835\/jlb0581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/100\/3\/581\/48716835\/jlb0581.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:35:41Z","timestamp":1677504941000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/100\/3\/581\/6932886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,10]]},"references-count":56,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,10]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.4a0915-405r","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2016,3,10]]}}}