{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:57:16Z","timestamp":1791176236639,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["01KI0788"],"award-info":[{"award-number":["01KI0788"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"H.W."},{"name":"M.C."},{"name":"M.R.-T."},{"name":"European Social Fund and the national budget"},{"name":"Human Capital Operational Programme"},{"DOI":"10.13039\/501100005297","name":"Medical University of Bialystok","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Gastroenterology"},{"DOI":"10.13039\/501100005624","name":"Hannover Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Interferon \u03b1-mediated effector functions of NK cells may contribute to the control of HCV replication and the pathogenesis of liver disease. The single-nucleotide polymorphism rs12979860 near IFNL3 (previously known as IL28B) is important in response to IFN-\u03b1 treatment and in spontaneous resolution of acute hepatitis C. The role of the IFNL3 polymorphism in NK cell function is unclear. Thus, we investigated the role of IFNL3 polymorphism in type I IFN-dependent regulation of NK cell functions in patients with cHC and healthy control subjects. We demonstrated a marked polarization of NK cells toward cytotoxicity in response to IFN-\u03b1 stimulation in patients with hepatitis C. That TRAIL up-regulation was present, particularly in patients with the IFNL3-TT allele, was supported by a shift in the pSTAT-1:pSTAT-4 ratios toward pSTAT-1. In patients bearing the IFNL3-TT allele, NK cell effector function correlated with liver disease activity. In contrast, higher cytokine production of NK cells was observed in healthy individuals with the IFNL3-CC genotype, which may support spontaneous HCV clearance in acute infection. Overall, these findings show that the role of NK cells may differ in chronic infection vs. early antiviral defense and that the IFNL3 genotype differentially influences NK cell function.<\/jats:p>","DOI":"10.1189\/jlb.4a1014-520r","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T03:35:04Z","timestamp":1433216104000},"page":"283-294","source":"Crossref","is-referenced-by-count":10,"title":["Altered effector functions of NK cells in chronic hepatitis C are associated with <i>IFNL3<\/i> polymorphism"],"prefix":"10.1093","volume":"98","author":[{"given":"Magdalena","family":"Rogalska-Taranta","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"},{"name":"Department of Infectious Diseases and Hepatology, Medical University of Bialystok , Bialystok , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoaneta A","family":"Markova","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Taranta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Lunemann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Schlaphoff","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Flisiak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, Medical University of Bialystok , Bialystok , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"},{"name":"German Center for Infection Research (DZIF) , Partner Site Hannover-Braunschweig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"},{"name":"German Center for Infection Research (DZIF) , Partner Site Hannover-Braunschweig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke R M","family":"Kraft","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School , Hannover , Germany"},{"name":"German Center for Infection Research (DZIF) , Partner Site Hannover-Braunschweig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"2023013012473970100_B1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.26141","article-title":"Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence","volume":"57","author":"Mohd Hanafiah","year":"2013","journal-title":"Hepatology"},{"key":"2023013012473970100_B2","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"issue":"Suppl 2","key":"2023013012473970100_B3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1478-3231.2011.02539.x","article-title":"A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel","volume":"31","author":"Cornberg","year":"2011","journal-title":"Liver Int."},{"key":"2023013012473970100_B4","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.jhep.2010.09.040","article-title":"Progress in the development of preventive and therapeutic vaccines for hepatitis C virus","volume":"54","author":"Torresi","year":"2011","journal-title":"J. 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