{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:00:32Z","timestamp":1793152832287,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"P.R.T.","award":["F32 EY022278"],"award-info":[{"award-number":["F32 EY022278"]}]},{"name":"E.P.","award":["R01 EY018612"],"award-info":[{"award-number":["R01 EY018612"]}]},{"name":"E.P.","award":["P30 EY011373"],"award-info":[{"award-number":["P30 EY011373"]}]},{"name":"Department of Ophthalmology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IL-6 and IL-23 (IL-6\/23) induce IL-17A (IL-17) production by a subpopulation of murine and human neutrophils, resulting in autocrine IL-17 activation, enhanced production of reactive oxygen species, and increased fungal killing. As IL-6 and IL-23 receptors trigger JAK1, \u22123\/STAT3 and JAK2\/STAT3 phosphorylation, respectively, we examined the role of this pathway in a murine model of fungal keratitis and also examined neutrophil elastase and gelatinase (matrix metalloproteinase 9) activity by IL-6\/23-stimulated human neutrophils in vitro. We found that STAT3 phosphorylation of neutrophils in Aspergillus fumigatus-infected corne as was inhibited by the JAK\/STAT inhibitor Ruxolitinib, resulting in impaired fungal killing and decreased matrix metalloproteinase 9 activity. In vitro, we showed that fungal killing by IL-6\/23-stimulated human peripheral blood neutrophils was impaired by JAK\/STAT inhibitors Ruxolitinib and Stattic, and by the retinoic acid receptor-related orphan receptor \u03b3t inhibitor SR1001. This was also associated with decreased reactive oxygen species, IL-17A production, and retinoic acid receptor-related orphan receptor \u03b3t translocation to the nucleus. We also demonstrate that IL-6\/23-activated neutrophils exhibit increased elastase and gelatinase (matrix metalloproteinase 9) activity, which is inhibited by Ruxolitinib and Stattic but not by SR1001. Taken together, these observations indicate that the regulation of activity of IL-17-producing neutrophils by JAK\/STAT inhibitors impairs reactive oxygen species production and fungal killing activity but also blocks elastase and gelatinase activity that can cause tissue damage.<\/jats:p>","DOI":"10.1189\/jlb.4a1015-483r","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T03:17:30Z","timestamp":1459480650000},"page":"213-222","source":"Crossref","is-referenced-by-count":42,"title":["JAK\/STAT regulation of <i>Aspergillus fumigatus<\/i> corneal infections and IL-6\/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity"],"prefix":"10.1093","volume":"100","author":[{"given":"Patricia R","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanhita","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan C","family":"Meszaros","sequence":"additional","affiliation":[{"name":"School of Medicine, Division of Rheumatology, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J","family":"Howell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J","family":"Malemud","sequence":"additional","affiliation":[{"name":"School of Medicine, Division of Rheumatology, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pearlman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,31]]},"reference":[{"key":"2023011710411569500_B1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/bjophthalmol-2014-305000","article-title":"Trends in bacterial and fungal keratitis in South India, 2002\u20132012","volume":"99","author":"Lalitha","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"2023011710411569500_B2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1442-9071.2009.02155.x","article-title":"Spectrum of fungal keratitis in central China","volume":"37","author":"Wang","year":"2009","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"2023011710411569500_B3","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.ophtha.2006.05.035","article-title":"Spectrum of fungal keratitis in north China","volume":"113","author":"Xie","year":"2006","journal-title":"Ophthalmology"},{"key":"2023011710411569500_B4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/jama.296.8.953","article-title":"Multistate outbreak of Fusarium keratitis associated with use of a contact lens solution","volume":"296","year":"2006","journal-title":"JAMA"},{"key":"2023011710411569500_B5","doi-asserted-by":"crossref","first-page":"e1000976","DOI":"10.1371\/journal.ppat.1000976","article-title":"Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis","volume":"6","author":"Leal","year":"2010","journal-title":"PLoS Pathog."},{"key":"2023011710411569500_B6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4049\/jimmunol.181.1.593","article-title":"MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2","volume":"181","author":"Tarabishy","year":"2008","journal-title":"J. Immunol."},{"key":"2023011710411569500_B7","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.4049\/jimmunol.1300748","article-title":"The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo","volume":"191","author":"Carrion Sde.","year":"2013","journal-title":"J. Immunol."},{"key":"2023011710411569500_B8","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1172\/JCI63239","article-title":"Fungal antioxidant pathways promote survival against neutrophils during infection","volume":"122","author":"Leal","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2023011710411569500_B9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4049\/jimmunol.1502037","article-title":"Zinc and manganese chelation by neutrophil S100A8\/A9 (calprotectin) limits extracellular Aspergillus fumigatus hyphal growth and corneal infection","volume":"196","author":"Clark","year":"2016","journal-title":"J. Immunol."},{"key":"2023011710411569500_B10","doi-asserted-by":"crossref","first-page":"e1003436","DOI":"10.1371\/journal.ppat.1003436","article-title":"Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum","volume":"9","author":"Leal","year":"2013","journal-title":"PLoS Pathog."},{"key":"2023011710411569500_B11","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/infdis\/jir426","article-title":"Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium","volume":"204","author":"Karthikeyan","year":"2011","journal-title":"J. Infect. Dis."},{"key":"2023011710411569500_B12","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/infdis\/jiu381","article-title":"Interleukin 17 expression in peripheral blood neutrophils from fungal keratitis patients and healthy cohorts in southern India","volume":"211","author":"Karthikeyan","year":"2015","journal-title":"J. Infect. Dis."},{"key":"2023011710411569500_B13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni.2797","article-title":"Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, ROR\u03b3t and dectin-2","volume":"15","author":"Taylor","year":"2014","journal-title":"Nat. Immunol."},{"key":"2023011710411569500_B14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3810\/pgm.2013.01.2628","article-title":"Ruxolitinib: an oral Janus kinase 1 and Janus kinase 2 inhibitor in the management of myelofibrosis","volume":"125","author":"Verstovsek","year":"2013","journal-title":"Postgrad. Med."},{"key":"2023011710411569500_B15","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1182\/blood-2009-04-214957","article-title":"Preclinical characterization of the selective JAK1\/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms","volume":"115","author":"Quint\u00e1s-Cardama","year":"2010","journal-title":"Blood"},{"key":"2023011710411569500_B16","doi-asserted-by":"crossref","first-page":"e54565","DOI":"10.1371\/journal.pone.0054565","article-title":"Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma","volume":"8","author":"Pan","year":"2013","journal-title":"PLoS One"},{"key":"2023011710411569500_B17","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","article-title":"Stattic: a small-molecule inhibitor of STAT3 activation and dimerization","volume":"13","author":"Schust","year":"2006","journal-title":"Chem. Biol."},{"key":"2023011710411569500_B18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature10075","article-title":"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand","volume":"472","author":"Solt","year":"2011","journal-title":"Nature"},{"key":"2023011710411569500_B19","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1158\/1078-0432.CCR-08-0377","article-title":"A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells","volume":"14","author":"Kong","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"2023011710411569500_B20","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/sj.bjc.6605691","article-title":"STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma","volume":"102","author":"Horiguchi","year":"2010","journal-title":"Br. J. Cancer"},{"key":"2023011710411569500_B21","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.4049\/jimmunol.1302235","article-title":"Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils","volume":"192","author":"Taylor","year":"2014","journal-title":"J. Immunol."},{"key":"2023011710411569500_B22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/157436209789057467","article-title":"Targeting JAK\/STAT signaling pathway in inflammatory diseases","volume":"4","author":"Malemud","year":"2009","journal-title":"Curr. Signal Transduct. Ther."},{"key":"2023011710411569500_B23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coi.2015.02.008","article-title":"The IL-6\/gp130\/STAT3 signaling axis: recent advances towards specific inhibition","volume":"34","author":"Garbers","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"2023011710411569500_B24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00211.x","article-title":"Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4","volume":"202","author":"Watford","year":"2004","journal-title":"Immunol. Rev."},{"key":"2023011710411569500_B25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1165\/rcmb.2003-0034OC","article-title":"Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils","volume":"29","author":"Owen","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023011710411569500_B26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature06764","article-title":"Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome","volume":"452","author":"Milner","year":"2008","journal-title":"Nature"},{"key":"2023011710411569500_B27","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1084\/jem.20080218","article-title":"Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3","volume":"205","author":"Ma","year":"2008","journal-title":"J. Exp. Med."},{"key":"2023011710411569500_B28","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1084\/jem.20080321","article-title":"Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells","volume":"205","author":"De Beaucoudrey","year":"2008","journal-title":"J. Exp. Med."},{"key":"2023011710411569500_B29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/science.1200439","article-title":"Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity","volume":"332","author":"Puel","year":"2011","journal-title":"Science"},{"key":"2023011710411569500_B30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1074-7613(00)80005-9","article-title":"Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils","volume":"10","author":"Takeda","year":"1999","journal-title":"Immunity"},{"key":"2023011710411569500_B31","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.1074\/jbc.C600321200","article-title":"STAT3 regulates cytokine-mediated generation of inflammatory helper T cells","volume":"282","author":"Yang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2023011710411569500_B32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"2023011710411569500_B33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri2800","article-title":"Innate IL-17-producing cells: the sentinels of the immune system","volume":"10","author":"Cua","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2023011710411569500_B34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","article-title":"Functional specialization of interleukin-17 family members","volume":"34","author":"Iwakura","year":"2011","journal-title":"Immunity"},{"key":"2023011710411569500_B35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2023011710411569500_B36","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1128\/IAI.05493-11","article-title":"Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection","volume":"79","author":"Werner","year":"2011","journal-title":"Infect. Immun."},{"key":"2023011710411569500_B37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1172\/JCI38702","article-title":"IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury","volume":"120","author":"Li","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2023011710411569500_B38","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.4049\/jimmunol.1202122","article-title":"Galectin-3 negatively regulates dendritic cell production of IL-23\/IL-17-axis cytokines in infection by Histoplasma capsulatum","volume":"190","author":"Wu","year":"2013","journal-title":"J. Immunol."},{"key":"2023011710411569500_B39","volume-title":"Mucosal Immunol","author":"Cai","year":"2015"},{"key":"2023011710411569500_B40","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4049\/jimmunol.1100123","article-title":"Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis","volume":"187","author":"Lin","year":"2011","journal-title":"J. Immunol."},{"key":"2023011710411569500_B41","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/jid.2013.526","article-title":"In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing ROR\u03b3t and IL-17","volume":"134","author":"Keijsers","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"2023011710411569500_B42","doi-asserted-by":"crossref","first-page":"e62231","DOI":"10.1371\/journal.pone.0062231","article-title":"Neutrophils are essential as a source of IL-17 in the effector phase of arthritis","volume":"8","author":"Katayama","year":"2013","journal-title":"PLoS One"},{"key":"2023011710411569500_B43","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1164\/rccm.201102-0236OC","article-title":"The Th17 pathway in cystic fibrosis lung disease","volume":"184","author":"Tan","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023011710411569500_B44","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1183\/09031936.00067110","article-title":"Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease","volume":"37","author":"Brodlie","year":"2011","journal-title":"Eur. Respir. J."},{"key":"2023011710411569500_B45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/thx.2003.008854","article-title":"Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways","volume":"59","author":"Prause","year":"2004","journal-title":"Thorax"},{"key":"2023011710411569500_B46","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1189\/jlb.1112600","article-title":"Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors","volume":"94","author":"Catz","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"2023011710411569500_B47","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/cmi.12328","article-title":"The role of Rab27a in the regulation of neutrophil function","volume":"16","author":"Catz","year":"2014","journal-title":"Cell. Microbiol."},{"key":"2023011710411569500_B48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1189\/jlb.1004612","article-title":"Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils","volume":"78","author":"Chakrabarti","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2023011710411569500_B49","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2567.2008.02980.x","article-title":"Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll\/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF)","volume":"127","author":"Brzezinska","year":"2009","journal-title":"Immunology"},{"key":"2023011710411569500_B50","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.4049\/jimmunol.1201881","article-title":"IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation","volume":"190","author":"Yan","year":"2013","journal-title":"J. Immunol."},{"key":"2023011710411569500_B51","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.immuni.2015.10.023","article-title":"Immune interactions with pathogenic and commensal fungi: a two-way street","volume":"43","author":"Underhill","year":"2015","journal-title":"Immunity"},{"key":"2023011710411569500_B52","first-page":"529","article-title":"Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis","volume":"132","author":"Bruce","year":"1985","journal-title":"Am. Rev. Respir. Dis."},{"key":"2023011710411569500_B53","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jcf.2015.03.003","article-title":"Inflammation in cystic fibrosis lung disease: pathogenesis and therapy","volume":"14","author":"Cantin","year":"2015","journal-title":"J. Cyst. Fibros."},{"key":"2023011710411569500_B54","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.150.3.8087357","article-title":"Neutrophil collagenase in sputum from patients with cystic fibrosis","volume":"150","author":"Power","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023011710411569500_B55","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-3-642-54490-3_16","article-title":"Ruxolitinib","volume":"201","author":"Becker","year":"2014","journal-title":"Recent Results Cancer Res."},{"key":"2023011710411569500_B56","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12185-013-1353-5","article-title":"Sensitivity and resistance of JAK2 inhibitors to myeloproliferative neoplasms","volume":"97","author":"Bhagwat","year":"2013","journal-title":"Int. J. Hematol."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.4A1015-483R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/100\/1\/213\/48717163\/jlb0213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/100\/1\/213\/48717163\/jlb0213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:35:46Z","timestamp":1677504946000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/100\/1\/213\/6932865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,31]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,3,31]]},"published-print":{"date-parts":[[2016,7,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.4a1015-483r","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,7]]},"published":{"date-parts":[[2016,3,31]]}}}