{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:09:34Z","timestamp":1793912974171,"version":"4.8.0"},"reference-count":190,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Streptococcus pyogenes, the Group A Streptococcus (GAS), is the most common cause of bacterial pharyngitis in children and adults. Innate and adaptive host immune responses are fundamental for defense against streptococcal pharyngitis and are central to the clinical manifestation of disease. Host immune responses also contribute to the severe poststreptococcal immune diseases that constitute the major disease burden for this organism. However, until recently, little was known about the host responses elicited during infection. Cellular mediators of innate immunity used during host defense against GAS include epithelial cells, neutrophils, macrophages, and dendritic cells (DCs), which are reported to secrete a number of soluble inflammatory mediators, such as antimicrobial peptides (AMPs); eicosanoids, including PGE2 and leukotriene B4 (LTB4); chemokines; and proinflammatory cytokines. Th1 and Th17 responses play significant roles in adaptive immunity in both murine models of GAS pharyngitis and in human tonsil tissue. A number of inflammatory complications are associated with GAS pharyngitis, which can lead to chronic disease in patients. These include scarlet fever, tonsillar hypertrophy, and sleep apnea, as well as postinfectious sequelae, such as acute rheumatic fever (ARF), poststreptococcal glomerulonephritis, and guttate psoriasis (GP). This review aims to present the current state of knowledge on innate and adaptive immune responses elicited during GAS pharyngitis, mechanisms by which GAS evades these responses, the emerging role of the pharyngeal microbiota, and how the interplay among these factors can influence the outcome of infection and inflammation-related complications.<\/jats:p>","DOI":"10.1189\/jlb.4mr0617-227rr","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T20:35:12Z","timestamp":1506458112000},"page":"193-213","source":"Crossref","is-referenced-by-count":48,"title":["Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies"],"prefix":"10.1093","volume":"103","author":[{"given":"Amelia T","family":"Soderholm","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland , Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C","family":"Barnett","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland , Brisbane, Australia"},{"name":"Telethon Kids Institute , Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Sweet","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, Institute for Molecular Bioscience Centre for Inflammation and Disease Research, Australian Infectious Diseases Research Centre, The University of Queensland , Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Walker","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland , Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"2023013012240396100_jlb10064-bib-0001","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJM200101183440308","article-title":"Acute pharyngitis","volume":"344","author":"Bisno","year":"2001","journal-title":"N. 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Cell Biol."},{"key":"2023013012240396100_jlb10064-bib-0026","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.micinf.2006.01.002","article-title":"Streptococcus pyogenes induces epithelial inflammatory responses through NF-kappaB\/MAPK signaling pathways","volume":"8","author":"Tsai","year":"2006","journal-title":"Microbes Infect."},{"key":"2023013012240396100_jlb10064-bib-0027","doi-asserted-by":"crossref","first-page":"e1005682","DOI":"10.1371\/journal.ppat.1005682","article-title":"Conquering neutrophils","volume":"12","author":"D\u00f6hrmann","year":"2016","journal-title":"PLoS Pathog."},{"key":"2023013012240396100_jlb10064-bib-0028","doi-asserted-by":"crossref","first-page":"e0168861","DOI":"10.1371\/journal.pone.0168861","article-title":"Co-activation of Th17 and antibody responses provides efficient protection against mucosal infection by Group A Streptococcus","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"key":"2023013012240396100_jlb10064-bib-0029","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1183\/09031936.03.00303503","article-title":"A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha","volume":"21","author":"Laan","year":"2003","journal-title":"Eur. 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Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0034","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nm1612","article-title":"DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection","volume":"13","author":"Walker","year":"2007","journal-title":"Nat. Med."},{"key":"2023013012240396100_jlb10064-bib-0035","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1128\/iai.65.6.2080-2087.1997","article-title":"Intranasal immunization with C5a peptidase prevents nasopharyngeal colonization of mice by the group A Streptococcus","volume":"65","author":"Ji","year":"1997","journal-title":"Infect. Immun."},{"key":"2023013012240396100_jlb10064-bib-0036","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1128\/iai.64.2.503-510.1996","article-title":"C5a peptidase alters clearance and trafficking of group A streptococci by infected mice","volume":"64","author":"Ji","year":"1996","journal-title":"Infect. Immun."},{"key":"2023013012240396100_jlb10064-bib-0037","doi-asserted-by":"crossref","first-page":"e82123","DOI":"10.1371\/journal.pone.0082123","article-title":"Non-invasive monitoring of Streptococcus pyogenes vaccine efficacy using biophotonic imaging","volume":"8","author":"Alam","year":"2013","journal-title":"PLoS One"},{"key":"2023013012240396100_jlb10064-bib-0038","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.chom.2008.07.002","article-title":"The IL-8 protease SpyCEP\/ScpC of group A Streptococcus promotes resistance to neutrophil killing","volume":"4","author":"Zinkernagel","year":"2008","journal-title":"Cell Host Microbe"},{"key":"2023013012240396100_jlb10064-bib-0039","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1365-2958.2010.07065.x","article-title":"Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract","volume":"76","author":"Kurupati","year":"2010","journal-title":"Mol. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0040","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1038\/sj.emboj.7601327","article-title":"A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues","volume":"25","author":"Hidalgo-Grass","year":"2006","journal-title":"EMBO J."},{"key":"2023013012240396100_jlb10064-bib-0041","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/cmi.12531","article-title":"Streptococcal toxins: role in pathogenesis and disease","volume":"17","author":"Barnett","year":"2015","journal-title":"Cell. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0042","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/IAI.71.1.446-455.2003","article-title":"Cytotoxic effects of streptolysin o and streptolysin S enhance the virulence of poorly encapsulated group a streptococci","volume":"71","author":"Sierig","year":"2003","journal-title":"Infect. Immun."},{"key":"2023013012240396100_jlb10064-bib-0043","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1086\/430617","article-title":"Cytocidal effect of Streptococcus pyogenes on mouse neutrophils in vivo and the critical role of streptolysin S","volume":"192","author":"Miyoshi-Akiyama","year":"2005","journal-title":"J. Infect. Dis."},{"key":"2023013012240396100_jlb10064-bib-0044","doi-asserted-by":"crossref","first-page":"e1002619","DOI":"10.1371\/journal.ppat.1002619","article-title":"The role of mast cells in the defence against pathogens","volume":"8","author":"Urb","year":"2012","journal-title":"PLoS Pathog."},{"key":"2023013012240396100_jlb10064-bib-0045","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.4049\/jimmunol.180.11.7565","article-title":"Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin","volume":"180","author":"Di Nardo","year":"2008","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0046","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1099\/jmm.0.020495-0","article-title":"Dermal mast cells reduce progressive tissue necrosis caused by subcutaneous infection with Streptococcus pyogenes in mice","volume":"60","author":"Matsui","year":"2011","journal-title":"J. Med. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0047","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1182\/blood-2007-07-104018","article-title":"Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation","volume":"111","author":"Von K\u00f6ckritz-Blickwede","year":"2008","journal-title":"Blood"},{"key":"2023013012240396100_jlb10064-bib-0048","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1128\/IAI.71.11.6171-6177.2003","article-title":"The streptococcal exotoxin streptolysin O activates mast cells to produce tumor necrosis factor alpha by p38 mitogen-activated protein kinase- and protein kinase C-dependent pathways","volume":"71","author":"Stassen","year":"2003","journal-title":"Infect. Immun."},{"key":"2023013012240396100_jlb10064-bib-0049","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1128\/IAI.70.7.3944-3947.2002","article-title":"Cysteine protease activity and histamine release from the human mast cell line HMC-1 stimulated by recombinant streptococcal pyrogenic exotoxin B\/streptococcal cysteine protease","volume":"70","author":"Watanabe","year":"2002","journal-title":"Infect. Immun."},{"key":"2023013012240396100_jlb10064-bib-0050","doi-asserted-by":"crossref","first-page":"e0119727","DOI":"10.1371\/journal.pone.0119727","article-title":"Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2","volume":"10","author":"Fieber","year":"2015","journal-title":"PLoS One"},{"key":"2023013012240396100_jlb10064-bib-0051","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.4049\/jimmunol.1101385","article-title":"Recruited macrophages control dissemination of group A Streptococcus from infected soft tissues","volume":"187","author":"Mishalian","year":"2011","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0052","doi-asserted-by":"crossref","first-page":"e1001345","DOI":"10.1371\/journal.ppat.1001345","article-title":"Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection","volume":"7","author":"Gratz","year":"2011","journal-title":"PLoS Pathog."},{"key":"2023013012240396100_jlb10064-bib-0053","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.chom.2016.02.003","article-title":"Type I interferon signaling prevents IL-1\u03b2-driven lethal systemic hyperinflammation during invasive bacterial infection of soft tissue","volume":"19","author":"Castiglia","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2023013012240396100_jlb10064-bib-0054","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1189\/jlb.0402212","article-title":"Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis","volume":"74","author":"Veckman","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"2023013012240396100_jlb10064-bib-0055","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/cei.12425","article-title":"Dynamin inhibition interferes with inflammasome activation and cytokine gene expression in Streptococcus pyogenes-infected human macrophages","volume":"178","author":"Latvala","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0056","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid storm in infection and inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0057","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.4049\/jimmunol.1000838","article-title":"Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes","volume":"185","author":"Goldmann","year":"2010","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0058","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1165\/rcmb.2008-0091TR","article-title":"Cyclic AMP: master regulator of innate immune cell function","volume":"39","author":"Serezani","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023013012240396100_jlb10064-bib-0059","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.4049\/jimmunol.1202932","article-title":"Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes","volume":"190","author":"Soares","year":"2013","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0060","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1462-5822.2008.01245.x","article-title":"Streptococcus pyogenes induces oncosis in macrophages through the activation of an inflammatory programmed cell death pathway","volume":"11","author":"Goldmann","year":"2009","journal-title":"Cell. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0061","doi-asserted-by":"crossref","first-page":"e1000145","DOI":"10.1371\/journal.ppat.1000145","article-title":"PerR confers phagocytic killing resistance and allows pharyngeal colonization by group A Streptococcus","volume":"4","author":"Gryllos","year":"2008","journal-title":"PLoS Pathog."},{"key":"2023013012240396100_jlb10064-bib-0062","doi-asserted-by":"crossref","first-page":"e62433","DOI":"10.1371\/journal.pone.0062433","article-title":"The AgI\/II family adhesin AspA is required for respiratory infection by Streptococcus pyogenes","volume":"8","author":"Franklin","year":"2013","journal-title":"PLoS One"},{"key":"2023013012240396100_jlb10064-bib-0063","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.chom.2013.11.003","article-title":"The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication","volume":"14","author":"Barnett","year":"2013","journal-title":"Cell Host Microbe"},{"key":"2023013012240396100_jlb10064-bib-0064","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pmed.0030053","article-title":"Viable group A streptococci in macrophages during acute soft tissue infection","volume":"3","author":"Thulin","year":"2006","journal-title":"PLoS Med."},{"key":"2023013012240396100_jlb10064-bib-0065","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1086\/523647","article-title":"The contribution of dendritic cells to host defenses against Streptococcus pyogenes","volume":"196","author":"Loof","year":"2007","journal-title":"J. Infect. Dis."},{"key":"2023013012240396100_jlb10064-bib-0066","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1189\/jlb.1003461","article-title":"Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells","volume":"75","author":"Veckman","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2023013012240396100_jlb10064-bib-0067","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jlb.58.2.225","article-title":"Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line","volume":"58","author":"Ye","year":"1995","journal-title":"J. Leukoc. Biol."},{"key":"2023013012240396100_jlb10064-bib-0068","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.imbio.2006.05.007","article-title":"Signal integration between IFNgamma and TLR signalling pathways in macrophages","volume":"211","author":"Schroder","year":"2006","journal-title":"Immunobiology"},{"key":"2023013012240396100_jlb10064-bib-0069","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1086\/428501","article-title":"Contribution of natural killer cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice","volume":"191","author":"Goldmann","year":"2005","journal-title":"J. Infect. Dis."},{"key":"2023013012240396100_jlb10064-bib-0070","doi-asserted-by":"crossref","first-page":"754","DOI":"10.2353\/ajpath.2010.090422","article-title":"Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88","volume":"176","author":"Loof","year":"2010","journal-title":"Am. J. Pathol."},{"key":"2023013012240396100_jlb10064-bib-0071","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fcimb.2014.00140","article-title":"Responses of innate immune cells to group A Streptococcus","volume":"4","author":"Fieber","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0072","doi-asserted-by":"crossref","first-page":"e1004266","DOI":"10.1371\/journal.ppat.1004266","article-title":"Host responses to group a streptococcus: cell death and inflammation","volume":"10","author":"Tsatsaronis","year":"2014","journal-title":"PLoS Pathog."},{"key":"2023013012240396100_jlb10064-bib-0073","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1128\/IAI.01680-07","article-title":"Immune recognition of Streptococcus pyogenes by dendritic cells","volume":"76","author":"Loof","year":"2008","journal-title":"Infect. 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Chem."},{"key":"2023013012240396100_jlb10064-bib-0075","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1126\/science.1220363","article-title":"TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification","volume":"337","author":"Oldenburg","year":"2012","journal-title":"Science"},{"key":"2023013012240396100_jlb10064-bib-0076","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.4049\/jimmunol.1403173","article-title":"TLR8 senses bacterial RNA in human monocytes and plays a nonredundant role for recognition of Streptococcus pyogenes","volume":"195","author":"Eigenbrod","year":"2015","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0077","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.15252\/embr.201540861","article-title":"Human TLR8 senses UR\/URR motifs in bacterial and mitochondrial RNA","volume":"16","author":"Kr\u00fcger","year":"2015","journal-title":"EMBO Rep."},{"key":"2023013012240396100_jlb10064-bib-0078","doi-asserted-by":"crossref","first-page":"e1003017","DOI":"10.1371\/journal.ppat.1003017","article-title":"Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1","volume":"8","author":"Campbell","year":"2012","journal-title":"PLoS Pathog."},{"key":"2023013012240396100_jlb10064-bib-0079","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.1103966","article-title":"Autophagy defends cells against invading group A Streptococcus","volume":"306","author":"Nakagawa","year":"2004","journal-title":"Science"},{"key":"2023013012240396100_jlb10064-bib-0080","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0081","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.4049\/jimmunol.0900444","article-title":"Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor","volume":"183","author":"Harder","year":"2009","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0082","doi-asserted-by":"crossref","first-page":"e00756-17","DOI":"10.1128\/mBio.00756-17","article-title":"Inhibition of inflammasome-dependent interleukin 1\u03b2 production by Streptococcal NAD(+)-glycohydrolase: evidence for extracellular activity","volume":"8","author":"Hancz","year":"2017","journal-title":"MBio"},{"key":"2023013012240396100_jlb10064-bib-0083","doi-asserted-by":"crossref","first-page":"e00133","DOI":"10.1128\/mBio.00133-15","article-title":"A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1\u03b2-dependent macrophage immune response","volume":"6","author":"Lin","year":"2015","journal-title":"MBio"},{"key":"2023013012240396100_jlb10064-bib-0084","doi-asserted-by":"crossref","first-page":"eaah3539","DOI":"10.1126\/sciimmunol.aah3539","article-title":"IL-1beta is an innate immune sensor of microbial proteolysis","volume":"1","author":"LaRock","year":"2016","journal-title":"Sci. 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Pathog."},{"key":"2023013012240396100_jlb10064-bib-0086","doi-asserted-by":"crossref","first-page":"e02215","DOI":"10.1128\/mBio.02215-15","article-title":"The NADase-negative variant of the Streptococcus pyogenes toxin NAD+ glycohydrolase induces JNK1-mediated programmed cellular necrosis","volume":"7","author":"Chandrasekaran","year":"2016","journal-title":"MBio"},{"key":"2023013012240396100_jlb10064-bib-0087","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1128\/IAI.71.2.948-955.2003","article-title":"Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells","volume":"71","author":"Okahashi","year":"2003","journal-title":"Infect. 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Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0090","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1073\/pnas.88.9.3720","article-title":"Cross-family dimerization of transcription factors Fos\/Jun and ATF\/CREB alters DNA binding specificity","volume":"88","author":"Hai","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013012240396100_jlb10064-bib-0091","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1128\/iai.65.6.2119-2126.1997","article-title":"Keratinocyte proinflammatory responses to adherent and nonadherent group A streptococci","volume":"65","author":"Wang","year":"1997","journal-title":"Infect. Immun."},{"key":"2023013012240396100_jlb10064-bib-0092","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1101029","article-title":"Regulation of immune responses by prostaglandin E2","volume":"188","author":"Kalinski","year":"2012","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0093","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fcimb.2013.00045","article-title":"PGE(2) suppression of innate immunity during mucosal bacterial infection","volume":"3","author":"Agard","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0094","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1073\/pnas.0906384107","article-title":"Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus","volume":"107","author":"Shea","year":"2010","journal-title":"Proc. Natl. Acad. Sci. 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Dis."},{"key":"2023013012240396100_jlb10064-bib-0097","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1099\/mic.0.2007\/009647-0","article-title":"Protein FOG is a moderate inducer of MIG\/CXCL9, and group G streptococci are more tolerant than group A streptococci to this chemokine's antibacterial effect","volume":"153","author":"Linge","year":"2007","journal-title":"Microbiology"},{"key":"2023013012240396100_jlb10064-bib-0098","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.dib.2016.02.061","article-title":"Kinetics of cytokine profile in response to Mycobacterium bovis BCG and Streptococcus pyogenes activated cells","volume":"7","author":"Verma","year":"2016","journal-title":"Data Brief"},{"key":"2023013012240396100_jlb10064-bib-0099","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1128\/IAI.01354-07","article-title":"A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response","volume":"76","author":"Sumby","year":"2008","journal-title":"Infect. 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Lett."},{"key":"2023013012240396100_jlb10064-bib-0104","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1189\/jlb.1206737","article-title":"Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages","volume":"84","author":"Miettinen","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"2023013012240396100_jlb10064-bib-0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bjorl.2015.05.003","article-title":"Evaluation of cytokines produced by \u03b2-hemolytic streptococcus in acute pharyngotonsillitis","volume":"81","author":"Le\u00e3o","year":"2015","journal-title":"Bras. J. Otorhinolaryngol."},{"key":"2023013012240396100_jlb10064-bib-0106","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.1073\/pnas.90.16.7676","article-title":"Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes","volume":"90","author":"Kapur","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013012240396100_jlb10064-bib-0107","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1128\/IAI.71.10.6019-6026.2003","article-title":"Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand","volume":"71","author":"Sakurai","year":"2003","journal-title":"Infect. 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Life Sci."},{"key":"2023013012240396100_jlb10064-bib-0112","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.4049\/jimmunol.1004179","article-title":"Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes","volume":"187","author":"Frick","year":"2011","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0113","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1523-1747.2001.01340.x","article-title":"Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus","volume":"117","author":"Dorschner","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"2023013012240396100_jlb10064-bib-0114","doi-asserted-by":"crossref","first-page":"7684","DOI":"10.4049\/jimmunol.179.11.7684","article-title":"Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways","volume":"179","author":"Yu","year":"2007","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2567.2007.02615.x","article-title":"Suppression of innate immunity by a nasal carriage strain of Staphylococcus aureus increases its colonization on nasal epithelium","volume":"122","author":"Quinn","year":"2007","journal-title":"Immunology"},{"key":"2023013012240396100_jlb10064-bib-0116","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.2041-1014.2012.640.x","article-title":"Streptococcus pyogenes infection of tonsil explants is associated with a human \u03b2-defensin 1 response from control but not recurrent acute tonsillitis patients","volume":"27","author":"Bell","year":"2012","journal-title":"Mol. Oral Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0117","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.0019-2805.2004.01837.x","article-title":"The interaction of streptococcal inhibitor of complement (SIC) and its proteolytic fragments with the human beta defensins","volume":"111","author":"Fernie-King","year":"2004","journal-title":"Immunology"},{"key":"2023013012240396100_jlb10064-bib-0118","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrmicro1441","article-title":"The co-evolution of host cationic antimicrobial peptides and microbial resistance","volume":"4","author":"Peschel","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0119","doi-asserted-by":"crossref","first-page":"16561","DOI":"10.1074\/jbc.M301995200","article-title":"SIC, a secreted protein of Streptococcus pyogenes that inactivates antibacterial peptides","volume":"278","author":"Frick","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2023013012240396100_jlb10064-bib-0120","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1128\/IAI.70.9.4908-4916.2002","article-title":"Streptococcal inhibitor of complement inhibits two additional components of the mucosal innate immune system: secretory leukocyte proteinase inhibitor and lysozyme","volume":"70","author":"Fernie-King","year":"2002","journal-title":"Infect. Immun."},{"key":"2023013012240396100_jlb10064-bib-0121","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1128\/IAI.68.2.535-542.2000","article-title":"Nonpolar inactivation of the hypervariable streptococcal inhibitor of complement gene (sic) in serotype M1 Streptococcus pyogenes significantly decreases mouse mucosal colonization","volume":"68","author":"Lukomski","year":"2000","journal-title":"Infect. Immun."},{"key":"2023013012240396100_jlb10064-bib-0122","doi-asserted-by":"crossref","first-page":"40891","DOI":"10.1074\/jbc.M112.404582","article-title":"A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides","volume":"287","author":"Hollands","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2023013012240396100_jlb10064-bib-0123","doi-asserted-by":"crossref","first-page":"e00394-12","DOI":"10.1128\/mBio.00394-12","article-title":"Vitamin D and the human antimicrobial peptide LL-37 enhance group a streptococcus resistance to killing by human cells","volume":"3","author":"Love","year":"2012","journal-title":"MBio"},{"key":"2023013012240396100_jlb10064-bib-0124","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000203645","article-title":"M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition","volume":"1","author":"Lauth","year":"2009","journal-title":"J. Innate Immun."},{"key":"2023013012240396100_jlb10064-bib-0125","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2015.09.004","article-title":"Group A Streptococcal M1 protein sequesters cathelicidin to evade innate immune killing","volume":"18","author":"LaRock","year":"2015","journal-title":"Cell Host Microbe"},{"key":"2023013012240396100_jlb10064-bib-0126","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1046\/j.1365-2567.2001.01249.x","article-title":"Streptococcal inhibitor of complement (SIC) inhibits the membrane attack complex by preventing uptake of C567 onto cell membranes","volume":"103","author":"Fernie-King","year":"2001","journal-title":"Immunology"},{"key":"2023013012240396100_jlb10064-bib-0127","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrmicro2366","article-title":"Molecular mechanisms of complement evasion: learning from staphylococci and meningococci","volume":"8","author":"Serruto","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0128","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4049\/jimmunol.154.1.375","article-title":"Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system","volume":"154","author":"Thern","year":"1995","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0129","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1073\/pnas.85.5.1657","article-title":"Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H","volume":"85","author":"Horstmann","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023013012240396100_jlb10064-bib-0130","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.4049\/jimmunol.161.9.4894","article-title":"Role of the hypervariable region in streptococcal M proteins: binding of a human complement inhibitor","volume":"161","author":"Johnsson","year":"1998","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0131","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2958.2005.04527.x","article-title":"Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathway","volume":"56","author":"Carlsson","year":"2005","journal-title":"Mol. Microbiol."},{"key":"2023013012240396100_jlb10064-bib-0132","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000353754","article-title":"Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing","volume":"6","author":"Ly","year":"2014","journal-title":"J. Innate Immun."},{"key":"2023013012240396100_jlb10064-bib-0133","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1002\/eji.201242683","article-title":"Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans","volume":"42","author":"Von Bernuth","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0134","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1128\/CMR.00001-11","article-title":"Infectious diseases in patients with IRAK-4, MyD88, NEMO, or I\u03baB\u03b1 deficiency","volume":"24","author":"Picard","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"2023013012240396100_jlb10064-bib-0135","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.4049\/jimmunol.1500804","article-title":"Adaptive immunity against Streptococcus pyogenes in adults involves increased IFN-\u03b3 and IgG3 responses compared with children","volume":"195","author":"Mortensen","year":"2015","journal-title":"J. Immunol."},{"key":"2023013012240396100_jlb10064-bib-0136","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000027560","article-title":"Haemophilus influenzae and Streptococcus pyogenes group A challenge induce a Th1 type of cytokine response in cells obtained from tonsillar hypertrophy and recurrent tonsillitis","volume":"60","author":"Agren","year":"1998","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"2023013012240396100_jlb10064-bib-0137","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1574-695X.2009.00540.x","article-title":"The early interferon response of nasal-associated lymphoid tissue to Streptococcus pyogenes infection","volume":"55","author":"Hyland","year":"2009","journal-title":"FEMS Immunol. Med. 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