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CD4+ LAP+ Tregs are a newly identified T cell subset with suppressive function on the immune response. This study was designed to investigate whether the circulating frequency and function of CD4+LAP+ Tregs would be impaired in patients with DCM. The results demonstrated that DCM patients had a significantly lower frequency of circulating CD4+LAP+ Tregs compared with control donors. CD4+LAP+ Tregs from DCM patients showed compromised function to suppress proliferation of CD4+ LAP\u2212CD25int\/low T cells and proliferation and IgG production of B cells. Moreover, B cell proliferation and IgG subset production could be directly suppressed by CD4+ LAP+ Tregs. TGF-\u03b2 and contact-dependent mechanisms were involved in CD4+LAP+ Treg-mediated suppression. Correlation analysis suggested that CD4+LAP+ Treg frequency was positively correlated with LVEF and negatively correlated with serum IgG3 and NT-proBNP concentration in patients with DCM. Our results are the first to demonstrate that the frequencies of CD4+LAP+ Tregs in patients with DCM are reduced and that their suppressive function is compromised. Defective CD4+ LAP+ Tregs may be an underlying mechanism of immune activation in DCM patients.<\/jats:p>","DOI":"10.1189\/jlb.5a1014-469rr","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T03:07:53Z","timestamp":1425006473000},"page":"797-805","source":"Crossref","is-referenced-by-count":18,"title":["Defective circulating CD4+LAP+ regulatory T cells in patients with dilated cardiomyopathy"],"prefix":"10.1093","volume":"97","author":[{"given":"Zheng-Feng","family":"Zhu","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology , Wuhan , China"},{"name":"Key Laboratory of Biological Targeted Therapy of the Ministry of Education , Wuhan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular 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