{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:28:27Z","timestamp":1740137307476,"version":"3.37.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C5575\/A15032"],"award-info":[{"award-number":["C5575\/A15032"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The EBV is known to persist in memory B cells, but it remains unclear how this affects cell numbers and humoral immunity. We here studied EBV persistence in memory B cell subsets and consequences on B cell memory in young children. EBV genome loads were quantified in 6 memory B cell subsets in EBV+ adults. The effects of EBV infection on memory B cell numbers and vaccination responses were studied longitudinally in children within the Generation R population cohort between 14 mo and 6 yr of age. EBV genomes were more numerous in CD27+IgG+, CD27+IgA+, and CD27\u2212IgA+ memory B cells than in IgM-only, natural effector, and CD27\u2212IgG+ B cells. The blood counts of IgM-only, CD27+IgA+, CD27\u2212IgG+, and CD27+IgG+ memory B cells were significantly lower in EBV+ children than in uninfected controls at 14 mo of age\u2014the age when these cells peak in numbers. At 6 yr, all of these memory B cell counts had normalized, as had plasma IgG levels to previous primary measles and booster tetanus vaccinations. In conclusion, EBV persists predominantly in Ig class-switched memory B cells, even when derived from T cell-independent responses (CD27\u2212IgA+), and EBV infection results in a transient depletion of these cells in young children.<\/jats:p>","DOI":"10.1189\/jlb.5vmab0616-283r","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T03:14:36Z","timestamp":1478574876000},"page":"949-956","source":"Crossref","is-referenced-by-count":8,"title":["Transient reduction in IgA+ and IgG+ memory B cell numbers in young EBV-seropositive children: the Generation R Study"],"prefix":"10.1093","volume":"101","author":[{"given":"Diana","family":"van den Heuvel","sequence":"first","affiliation":[{"name":"Department of Immunology, Erasmus Medical Center, University Medical Center , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A E","family":"Jansen","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus Medical Center, University Medical Center , Rotterdam , The Netherlands"},{"name":"Department of Pediatrics, Erasmus Medical Center-Sophia , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew I","family":"Bell","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham , Edgbaston, Birmingham , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B","family":"Rickinson","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham , Edgbaston, Birmingham , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent W V","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus Medical Center, University Medical Center , Rotterdam , The Netherlands"},{"name":"Department of Pediatrics, Erasmus Medical Center-Sophia , Rotterdam , The Netherlands"},{"name":"Department of Epidemiology, Erasmus Medical Center, University Medical Center , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques J M","family":"van Dongen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus Medical Center, University Medical Center , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette A","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Erasmus Medical Center-Sophia , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menno C","family":"van Zelm","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus Medical Center, University Medical Center , Rotterdam , The Netherlands"},{"name":"Department of Immunology and Pathology, Central Clinical School, Monash University , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"2023011712062412200_B1","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1073\/pnas.81.14.4510","article-title":"Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2","volume":"81","author":"Fingeroth","year":"1984","journal-title":"Proc. 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