{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T16:26:16Z","timestamp":1766766376541,"version":"3.37.3"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fondo de Investigaciones Sanitarias"},{"name":"Spanish National Institute of Health","award":["FIS 03\/0142","PS 09\/00229","FI07\/00054"],"award-info":[{"award-number":["FIS 03\/0142","PS 09\/00229","FI07\/00054"]}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["SAF2010-21224"],"award-info":[{"award-number":["SAF2010-21224"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Catalan HIV Vaccine Development Program"},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Catalan Government","award":["2010FI_B1 00,023"],"award-info":[{"award-number":["2010FI_B1 00,023"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation and BST","doi-asserted-by":"publisher","award":["PTQ-09-02-017050","CES 07\/015"],"award-info":[{"award-number":["PTQ-09-02-017050","CES 07\/015"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III and Direcci\u00f3 d'Estrat\u00e8gia i Coordinaci\u00f3","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Department of the Catalan Government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>cDCs and pDCs differ in multiple aspects. Among those, antigen capture is a recognized feature of cDCs, whereas pDCs display poor capacity to capture cell-derived antigens. However, animal models of organ transplantation suggested a role for pDCs in tolerance induction via phagocytosis of donor antigens. In a transplantation setting, microvesicles, such as apoptotic bodies and exosomes secreted by the graft, may be potential sources of alloantigen. Here, we tested the capacity of human pDCs to capture exosomes and apoptotic bodies from Jurkat T cells. Exosomes and apoptotic bodies were indeed captured by pDCs, although required longer times of incubation when compared with the highly endocytic cDCs. In cDCs and pDCs, exosome capture was more efficient than apoptotic bodies. Endocytosis inhibitors clearly impaired exosome capture by cDCs, although this could not be verified in pDCs as a result of cellular toxicity. Functionally, capture of Jurkat-derived exosomes did not induce nor prevent pDC maturation, and exosome-loaded pDCs induced T cell proliferation, suggesting a link between capture and presentation. Thus, exosomes and apoptotic bodies may be sources of antigen for human pDCs.<\/jats:p>","DOI":"10.1189\/jlb.0111054","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T11:39:31Z","timestamp":1328787571000},"page":"751-758","source":"Crossref","is-referenced-by-count":43,"title":["Capture of cell-derived microvesicles (exosomes and apoptotic bodies) by human plasmacytoid dendritic cells"],"prefix":"10.1093","volume":"91","author":[{"given":"Patricia","family":"Bastos-Amador","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiology for Research and Applications to Diagnosis (LIRAD), Blood and Tissue Bank (BST), Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, Institut Investigaci\u00f3 Germans Trias i Pujol (IGTP) , Badalona (Barcelona), Spain"}]},{"given":"Bego\u00f1a","family":"P\u00e9rez-Cabezas","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology for Research and Applications to Diagnosis (LIRAD), Blood and Tissue Bank (BST), Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, Institut Investigaci\u00f3 Germans Trias i Pujol (IGTP) , Badalona (Barcelona), Spain"}]},{"given":"Nuria","family":"Izquierdo-Useros","sequence":"additional","affiliation":[{"name":"IrsiCaixa Foundation, HIVACAT , Badalona (Barcelona), Spain"}]},{"given":"Maria C","family":"Puertas","sequence":"additional","affiliation":[{"name":"IrsiCaixa Foundation, HIVACAT , Badalona (Barcelona), Spain"}]},{"given":"Javier","family":"Martinez-Picado","sequence":"additional","affiliation":[{"name":"IrsiCaixa Foundation, HIVACAT , Badalona (Barcelona), Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA) , Barcelona, Spain"}]},{"given":"Ricardo","family":"Pujol-Borrell","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology for Research and Applications to Diagnosis (LIRAD), Blood and Tissue Bank (BST), Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, Institut Investigaci\u00f3 Germans Trias i Pujol (IGTP) , Badalona (Barcelona), Spain"}]},{"given":"Mar","family":"Naranjo-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology for Research and Applications to Diagnosis (LIRAD), Blood and Tissue Bank (BST), Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, Institut Investigaci\u00f3 Germans Trias i Pujol (IGTP) , Badalona (Barcelona), Spain"}]},{"given":"Francesc E","family":"Borr\u00e0s","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology for Research and Applications to Diagnosis (LIRAD), Blood and Tissue Bank (BST), Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, Institut Investigaci\u00f3 Germans Trias i Pujol (IGTP) , Badalona (Barcelona), Spain"}]}],"member":"286","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"2023020612141800000_B1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri746","article-title":"Mouse and human dendritic cell subtypes","volume":"2","author":"Shortman","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2023020612141800000_B2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nri2103","article-title":"Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo","volume":"7","author":"Villadangos","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2023020612141800000_B3","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1182\/blood-2002-10-3063","article-title":"Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity","volume":"101","author":"Fonteneau","year":"2003","journal-title":"Blood"},{"key":"2023020612141800000_B4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1084\/jem.20021091","article-title":"Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells","volume":"197","author":"Krug","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023020612141800000_B5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1084\/jem.20031059","article-title":"CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens","volume":"199","author":"Salio","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023020612141800000_B6","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1182\/blood-2004-02-0426","article-title":"Murine plasmacytoid dendritic cells induce effector\/memory CD8+ T-cell responses in vivo after viral stimulation","volume":"104","author":"Schlecht","year":"2004","journal-title":"Blood"},{"volume-title":"Nat. Immunol","year":"2008","author":"Young","key":"2023020612141800000_B7"},{"key":"2023020612141800000_B8","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.4049\/jimmunol.163.3.1409","article-title":"A CD1a+\/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells","volume":"163","author":"Ito","year":"1999","journal-title":"J. Immunol."},{"key":"2023020612141800000_B9","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2769::AID-IMMU2769>3.0.CO;2-2","article-title":"Human peripheral blood contains two distinct lineages of dendritic cells","volume":"29","author":"Robinson","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"2023020612141800000_B10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1084\/jem.20040035","article-title":"Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen","volume":"200","author":"De Heer","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023020612141800000_B11","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1084\/jem.20062373","article-title":"Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells","volume":"204","author":"Sapoznikov","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023020612141800000_B12","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1084\/jem.194.12.1823","article-title":"BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha\/beta induction","volume":"194","author":"Dzionek","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023020612141800000_B13","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1182\/blood-2005-09-3746","article-title":"Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12","volume":"107","author":"Blasius","year":"2006","journal-title":"Blood"},{"key":"2023020612141800000_B14","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1182\/blood-2007-03-081398","article-title":"Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-\u03b1 production","volume":"111","author":"Meyer-Wentrup","year":"2008","journal-title":"Blood"},{"key":"2023020612141800000_B15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI23025","article-title":"Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9","volume":"115","author":"Means","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2023020612141800000_B16","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1084\/jem.20052364","article-title":"Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc \u03b3 RII-mediated uptake","volume":"203","author":"Benitez-Ribas","year":"2006","journal-title":"J. Exp. Med."},{"key":"2023020612141800000_B17","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1182\/blood-2004-08-3105","article-title":"Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery","volume":"105","author":"Schnurr","year":"2005","journal-title":"Blood"},{"key":"2023020612141800000_B18","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ni1333","article-title":"Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts","volume":"7","author":"Ochando","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023020612141800000_B19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1189\/jlb.1204711","article-title":"Differential capability for phagocytosis of apoptotic and necrotic leukemia cells by human peripheral blood dendritic cell subsets","volume":"77","author":"Dalgaard","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2023020612141800000_B20","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1084\/jem.185.6.1101","article-title":"The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand","volume":"185","author":"Grouard","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023020612141800000_B21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.10118","article-title":"Heterogeneity of freshly isolated human tonsil dendritic cells demonstrated by intracellular markers, phagocytosis, and membrane dye transfer","volume":"48","author":"Stent","year":"2002","journal-title":"Cytometry"},{"key":"2023020612141800000_B22","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.3324\/haematol.2009.010934","article-title":"Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory diseases","volume":"94","author":"Angelot","year":"2009","journal-title":"Haematologica"},{"key":"2023020612141800000_B23","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.4049\/jimmunol.0903286","article-title":"Human plasmacytoid dendritic cells phagocytose, process, and present exogenous particulate antigen","volume":"184","author":"Tel","year":"2010","journal-title":"J. Immunol."},{"key":"2023020612141800000_B24","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1182\/blood-2008-05-158642","article-title":"Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway","volume":"113","author":"Izquierdo-Useros","year":"2009","journal-title":"Blood"},{"key":"2023020612141800000_B25","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.4049\/jimmunol.1100203","article-title":"Ligation of notch receptors in human conventional and plasmacytoid dendritic cells differentially regulates cytokine and chemokine secretion and modulates Th cell polarization","volume":"186","author":"P\u00e9rez-Cabezas","year":"2011","journal-title":"J. Immunol."},{"volume-title":"Curr. Protoc. Cell Biol","year":"2006","author":"Th\u00e9ry","key":"2023020612141800000_B26"},{"key":"2023020612141800000_B27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2249.2009.04082.x","article-title":"Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes","volume":"160","author":"Marin-Gallen","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"2023020612141800000_B28","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.4049\/jimmunol.166.12.7309","article-title":"Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles","volume":"166","author":"Th\u00e9ry","year":"2001","journal-title":"J. Immunol."},{"key":"2023020612141800000_B29","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood-2011-02-338004","article-title":"Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes","volume":"119","author":"Montecalvo","year":"2012","journal-title":"Blood"},{"key":"2023020612141800000_B30","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.4049\/jimmunol.179.3.1489","article-title":"CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo","volume":"179","author":"Segura","year":"2007","journal-title":"J. Immunol."},{"key":"2023020612141800000_B31","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1182\/blood-2004-03-0824","article-title":"Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells","volume":"104","author":"Morelli","year":"2004","journal-title":"Blood"},{"key":"2023020612141800000_B32","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.immuni.2007.07.021","article-title":"Antigen crosspresentation by human plasmacytoid dendritic cells","volume":"27","author":"Hoeffel","year":"2007","journal-title":"Immunity"},{"key":"2023020612141800000_B33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1600-065X.2003.00079.x","article-title":"Dendritic cells: regulators of allo-immunity and opportunities for tolerance induction","volume":"196","author":"Morelli","year":"2003","journal-title":"Immunol. Rev."},{"key":"2023020612141800000_B34","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.4049\/jimmunol.168.4.1627","article-title":"Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation","volume":"168","author":"Stuart","year":"2002","journal-title":"J. Immunol."},{"key":"2023020612141800000_B35","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1084\/jem.20020263","article-title":"Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7","volume":"196","author":"Verbovetski","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023020612141800000_B36","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/intimm\/dxh267","article-title":"Exosomal-like vesicles are present in human blood plasma","volume":"17","author":"Caby","year":"2005","journal-title":"Int. Immunol."},{"key":"2023020612141800000_B37","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/ni854","article-title":"Indirect activation of na\u00efve CD4+ T cells by dendritic cell-derived exosomes","volume":"3","author":"Th\u00e9ry","year":"2002","journal-title":"Nat. Immunol."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.0111054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/91\/5\/751\/48407065\/jlb0751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/91\/5\/751\/48407065\/jlb0751.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:11:54Z","timestamp":1677503514000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/91\/5\/751\/6960334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,1]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,1]]},"published-print":{"date-parts":[[2012,5,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.0111054","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"type":"print","value":"0741-5400"},{"type":"electronic","value":"1938-3673"}],"subject":[],"published-other":{"date-parts":[[2012,5]]},"published":{"date-parts":[[2012,5,1]]}}}