{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:22:42Z","timestamp":1771651362492,"version":"3.50.1"},"reference-count":137,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T00:00:00Z","timestamp":1144368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In addition to oxidative and antibiotic mechanisms of antimicrobial activity, macrophages are able to deprive intracellular pathogens of required nutrients. Thus, microbial killing may not rely only in the toxic environment the microbe reaches but also may result from the scarcity of nutrients in the cellular compartment it occupies. Here, we analyze evidence for such nutriprive (from the latin privare, to deprive of nutrients), antimicrobial mechanisms. Although the direct analysis of nutrient availability is most often not feasible, indirect evidence of lack of nutrients in the microbial organelles has been inferred from the study of mutants, the analysis of gene expression, and the consequences of changing the intracellular location of the pathogen. We propose that according to the microbe and its survival strategy, different mechanisms to impede access to nutrients may be constitutively present or may be induced by cytokines and other pathways. Thus, membrane transporters may remove nutrients from vacuolar compartments, and enzymes may degrade some growth factors. A series of diverse compounds may sequester other molecules required for microbial growth, as exemplified by the action of iron chelators. Modulation of vesicular trafficking may prevent the fusion of certain vesicles containing nutrients with those containing the pathogen, counteracting the evasion strategies of the pathogen. The understanding of these mechanisms will certainly help in designing new therapeutic and prophylactic approaches to preventing infectious diseases.<\/jats:p>","DOI":"10.1189\/jlb.0206079","type":"journal-article","created":{"date-parts":[[2006,4,8]],"date-time":"2006-04-08T00:26:47Z","timestamp":1144456007000},"page":"1117-1128","source":"Crossref","is-referenced-by-count":119,"title":["Macrophage nutriprive antimicrobial mechanisms"],"prefix":"10.1093","volume":"79","author":[{"given":"Rui","family":"Appelberg","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology and Immunology of Infection, IBMC-Institute for Molecular and Cell Biology and ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, University of Porto , Portugal"}]}],"member":"286","published-online":{"date-parts":[[2006,4,7]]},"reference":[{"key":"2023033015235969500_cit-1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.mi.38.100184.000331","article-title":"The role of oxygen and its derivatives in microbial pathogenesis and host defense","volume":"38","author":"Beaman","year":"1984","journal-title":"Annu. Rev. Microbiol."},{"key":"2023033015235969500_cit-2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(94)90266-6","article-title":"Nitric oxide synthases: roles, tolls, and controls","volume":"78","author":"Nathan","year":"1994","journal-title":"Cell"},{"key":"2023033015235969500_cit-3","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.4049\/jimmunol.150.7.2901","article-title":"Reactive nitrogen intermediates suppress the primary immunologic response to","volume":"150","author":"Gregory","year":"1993","journal-title":"Listeria. J. Immunol."},{"key":"2023033015235969500_cit-4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/cimm.1996.0198","article-title":"Immunoregulatory role of nitric oxide in Legionella pneumophila-infected macrophages","volume":"171","author":"Yamamoto","year":"1996","journal-title":"Cell. Immunol."},{"key":"2023033015235969500_cit-5","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1128\/iai.62.8.3197-3205.1994","article-title":"Inhibition of Legionella pneumophila growth by \u03b3 interferon in permissive A\/J mouse macrophages: role of reactive oxygen species, nitric oxide, tryptophan, and iron(III)","volume":"62","author":"Gebran","year":"1994","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-6","first-page":"352","article-title":"Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages","volume":"80","author":"Appelberg","year":"1993","journal-title":"Immunology"},{"key":"2023033015235969500_cit-7","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.4049\/jimmunol.162.11.6734","article-title":"Improved clearance of Mycobacterium avium upon disruption of the iNOS gene","volume":"162","author":"Gomes","year":"1999","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-8","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1128\/IAI.72.7.4081-4089.2004","article-title":"Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice","volume":"72","author":"Cummings","year":"2004","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-9","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/eji.200425029","article-title":"Control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88","volume":"34","author":"von Loewenich","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"2023033015235969500_cit-10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.192.3.347","article-title":"Depletion of CD4+ T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon \u03b3 and nitric oxide synthase 2","volume":"192","author":"Scanga","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1074-7613(00)80004-7","article-title":"Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase","volume":"10","author":"Shiloh","year":"1999","journal-title":"Immunity"},{"key":"2023033015235969500_cit-12","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.4049\/jimmunol.156.12.4764","article-title":"Mycobacterium avium- and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion-competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemma","volume":"156","author":"Russell","year":"1996","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-13","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1002\/j.1460-2075.1996.tb01088.x","article-title":"Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis","volume":"15","author":"Sturgill-Koszycki","year":"1996","journal-title":"EMBO J."},{"key":"2023033015235969500_cit-14","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.4049\/jimmunol.153.6.2568","article-title":"Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages","volume":"153","author":"Xu","year":"1994","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mib.2003.12.005","article-title":"Salmonella redirects phagosomal maturation","volume":"7","author":"Brumell","year":"2004","journal-title":"Curr. Opin. Microbiol."},{"key":"2023033015235969500_cit-16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1242\/jcs.103.4.1193","article-title":"Intracellular trafficking and the parasitophorous vacuole of Leishmania mexicana-infected macrophages","volume":"103","author":"Russell","year":"1992","journal-title":"J. Cell Sci."},{"key":"2023033015235969500_cit-17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1242\/jcs.112.5.681","article-title":"Parasitophorous vacuoles of Leishmania mexicana acquire macromolecules from the host cell cytosol via two independent routes","volume":"112","author":"Schaible","year":"1999","journal-title":"J. Cell Sci."},{"key":"2023033015235969500_cit-18","first-page":"1471","article-title":"Receptor-mediated entry of \u03b2-glucoronidase into the parasitophorous vacuoles of macrophages infected with","volume":"157","author":"Shepherd","year":"1983","journal-title":"Leishmania mexicana amazonensis. J. Exp. Med."},{"key":"2023033015235969500_cit-19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1242\/jcs.110.2.191","article-title":"Transfer of phagocytosed particles to the parasitophorous vacuole of Leishmania mexicana is a transient phenomenon preceding the acquisition of annexin I by the phagosome","volume":"110","author":"Collins","year":"1997","journal-title":"J. Cell Sci."},{"key":"2023033015235969500_cit-20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1084\/jem.176.3.639","article-title":"Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with","volume":"176","author":"Veras","year":"1992","journal-title":"Leishmania amazonensis. J. Exp. Med."},{"key":"2023033015235969500_cit-21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.200205011","article-title":"The road less traveled: transport of Legionella to the endoplasmic reticulum","volume":"158","author":"Roy","year":"2002","journal-title":"J. Cell Biol."},{"key":"2023033015235969500_cit-22","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.192.9.1261","article-title":"Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles","volume":"192","author":"Sturgill-Koszycki","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev.micro.51.1.415","article-title":"Safe haven: the cell biology of nonfusogenic pathogen vacuoles","volume":"51","author":"Sinai","year":"1997","journal-title":"Annu. Rev. Microbiol."},{"key":"2023033015235969500_cit-24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1083\/jcb.200101073","article-title":"The Toxoplasma gondii protein ROP2 mediates host organelle association with the parasitophorous vacuole membrane","volume":"154","author":"Sinai","year":"2001","journal-title":"J. Cell Biol."},{"key":"2023033015235969500_cit-25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20030088","article-title":"Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum","volume":"198","author":"Celli","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0966-842X(03)00078-7","article-title":"What is the nature of the replicative niche of a stealthy bug named","volume":"11","author":"K\u00f6hler","year":"2003","journal-title":"Brucella. Trends Microbiol."},{"key":"2023033015235969500_cit-27","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200205009","article-title":"The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity","volume":"158","author":"Portnoy","year":"2002","journal-title":"J. Cell Biol."},{"key":"2023033015235969500_cit-28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0962-8924(00)88965-5","article-title":"Lysosome recruitment during host cell invasion by","volume":"5","author":"Andrews","year":"1995","journal-title":"Trypanosoma cruzi. Trends Cell Biol."},{"key":"2023033015235969500_cit-29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1462-5822.2005.00652.x","article-title":"Intracellular survival of","volume":"8","author":"Ogawa","year":"2006","journal-title":"Shigella. Cell. Microbiol."},{"key":"2023033015235969500_cit-30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tim.2005.06.009","article-title":"A nutritive view on the host-pathogen interplay","volume":"13","author":"Schaible","year":"2005","journal-title":"Trends Microbiol."},{"key":"2023033015235969500_cit-31","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.4049\/jimmunol.174.3.1491","article-title":"Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system","volume":"174","author":"Wagner","year":"2005","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-32","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1128\/IAI.72.4.2022-2028.2004","article-title":"The nature of extracellular iron influences iron acquisition by Mycobacterium tuberculosis residing within human macrophages","volume":"72","author":"Olakanmi","year":"2004","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-33","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0891-5849(02)01006-7","article-title":"The labile iron pool: characterization, measurement, and participation in cellular processes","volume":"33","author":"Kakhlon","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"2023033015235969500_cit-34","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/iai.59.5.1823-1831.1991","article-title":"Evidence that vesicles containing living, virulent Mycobacterium tuberculosis or Mycobacterium avium in cultured human macrophages are not acidic","volume":"59","author":"Crowle","year":"1991","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-35","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.8303277","article-title":"Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase","volume":"263","author":"Sturgill-Koszycki","year":"1994","journal-title":"Science"},{"key":"2023033015235969500_cit-36","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/291238a0","article-title":"Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines","volume":"291","author":"Hoiseth","year":"1981","journal-title":"Nature"},{"key":"2023033015235969500_cit-37","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1073\/pnas.83.14.5189","article-title":"Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent","volume":"83","author":"Fields","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-38","doi-asserted-by":"crossref","first-page":"11470","DOI":"10.1073\/pnas.88.24.11470","article-title":"Intracellular replication is essential for the virulence of","volume":"88","author":"Leung","year":"1991","journal-title":"Salmonella typhimurium. Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-39","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1139\/m81-195","article-title":"Naturally occurring prototrophic strains of","volume":"27","author":"Virgilio","year":"1981","journal-title":"Salmonella typhi. Can. J. Microbiol."},{"key":"2023033015235969500_cit-40","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/iai.65.2.587-596.1997","article-title":"Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence","volume":"65","author":"Klose","year":"1997","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-41","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1128\/IAI.67.6.2867-2873.1999","article-title":"Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine","volume":"67","author":"Jackson","year":"1999","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-42","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1128\/IAI.73.1.666-670.2005","article-title":"Reduced local growth and spread but preserved pathogenicity of a \u0394purC Mycobacterium tuberculosis auxotrophic mutant in \u03b3 interferon receptor-deficient mice after aerosol infection","volume":"73","author":"Brown","year":"2005","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-43","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1128\/IAI.68.5.2888-2898.2000","article-title":"Attenuation of and protection induced by a leucine auxotroph of","volume":"68","author":"Hondalus","year":"2000","journal-title":"Mycobacterium tuberculosis. Infect. Immun."},{"key":"2023033015235969500_cit-44","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1128\/IAI.71.7.4190-4192.2003","article-title":"Vaccine efficacy of a lysine auxotroph of","volume":"71","author":"Pavelka","year":"2003","journal-title":"Mycobacterium tuberculosis. Infect. Immun."},{"key":"2023033015235969500_cit-45","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nm765","article-title":"A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis","volume":"8","author":"Sambandamurthy","year":"2002","journal-title":"Nat. Med."},{"key":"2023033015235969500_cit-46","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/iai.63.3.1004-1012.1995","article-title":"In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis","volume":"63","author":"McAdam","year":"1995","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-47","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1128\/iai.64.5.1794-1799.1996","article-title":"Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages","volume":"64","author":"Bange","year":"1996","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-48","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1128\/iai.56.6.1449-1455.1988","article-title":"Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes","volume":"56","author":"Mintz","year":"1988","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-49","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1128\/iai.64.6.2188-2192.1996","article-title":"Deletion of purE attenuates Brucell melitensis infection in mice","volume":"64","author":"Crawford","year":"1996","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-50","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1128\/iai.61.9.3756-3760.1993","article-title":"Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants","volume":"61","author":"Marquis","year":"1993","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-51","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/iai.56.2.419-423.1988","article-title":"Characterization of aromatic- and purine-dependent Salmonella typhimurium: attenuation, persistence, and ability to induce protective immunity in BALB\/c mice","volume":"56","author":"O'Callaghan","year":"1988","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-52","first-page":"185","volume-title":"The Biology of Mycobacteria, Volume 1, Physiology, Identification and Classification","author":"Ratledge","year":"1982"},{"key":"2023033015235969500_cit-53","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1128\/IAI.69.2.1442-1150.2001","article-title":"Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates","volume":"69","author":"Smith","year":"2001","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-54","doi-asserted-by":"crossref","first-page":"15711","DOI":"10.1073\/pnas.232454299","article-title":"The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell","volume":"99","author":"K\u00f6hler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-55","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1128\/aem.57.10.3046-3048.1991","article-title":"Development of an improved chemically defined minimal medium for","volume":"57","author":"Premaratne","year":"1991","journal-title":"Listeria monocytogenes. Appl. Environ. Microbiol."},{"key":"2023033015235969500_cit-56","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1128\/iai.57.11.3629-3636.1989","article-title":"Listeriolysin O is essential for virulence of Listeria monocytogenes: direct evidence obtained by gene complementation","volume":"57","author":"Cossart","year":"1989","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-57","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1084\/jem.167.4.1459","article-title":"Role of hemolysin for the intracellular growth of","volume":"167","author":"Portnoy","year":"1988","journal-title":"Listeria monocytogenes. J. Exp. Med."},{"key":"2023033015235969500_cit-58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1083\/jcb.149.1.167","article-title":"Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition","volume":"149","author":"Coppens","year":"2000","journal-title":"J. Cell Biol."},{"key":"2023033015235969500_cit-59","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1462-5822.2005.00518.x","article-title":"Host cell lipids control cholesteryl ester synthesis and storage in intracellular","volume":"7","author":"Nishikawa","year":"2005","journal-title":"Toxoplasma. Cell. Microbiol."},{"key":"2023033015235969500_cit-60","doi-asserted-by":"crossref","first-page":"31221","DOI":"10.1074\/jbc.M404232200","article-title":"Purine salvage pathways in the apicomplexan parasite","volume":"279","author":"Chaudhary","year":"2004","journal-title":"Toxoplasma gondii. J. Biol. Chem."},{"key":"2023033015235969500_cit-61","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1073\/pnas.91.2.509","article-title":"The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve","volume":"91","author":"Schwab","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-62","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1128\/EC.3.2.245-254.2004","article-title":"Nucleoside and nucleobase transporters in parasitic protozoa","volume":"3","author":"Landfear","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"2023033015235969500_cit-63","first-page":"7161","article-title":"Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and","volume":"181","author":"Honer Zu Bentrup","year":"1999","journal-title":"Mycobacterium tuberculosis. J. Bacteriol."},{"key":"2023033015235969500_cit-64","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/35021074","article-title":"Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase","volume":"406","author":"McKinney","year":"2000","journal-title":"Nature"},{"key":"2023033015235969500_cit-65","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1128\/IAI.73.4.2547-2549.2005","article-title":"Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice","volume":"73","author":"Fang","year":"2005","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-66","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/35083594","article-title":"The glyoxylate cycle is required for fungal virulence","volume":"412","author":"Lorenz","year":"2001","journal-title":"Nature"},{"key":"2023033015235969500_cit-67","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1128\/iai.37.3.1042-1049.1982","article-title":"Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions","volume":"37","author":"Wayne","year":"1982","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-68","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/iai.64.2.629-636.1996","article-title":"Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection","volume":"64","author":"Pope","year":"1996","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-69","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1073\/pnas.97.3.1252","article-title":"The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages","volume":"97","author":"de Voss","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-70","doi-asserted-by":"crossref","first-page":"12844","DOI":"10.1073\/pnas.96.22.12844","article-title":"Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor","volume":"96","author":"Manabe","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-71","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1093\/emboj\/16.17.5376","article-title":"The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival","volume":"16","author":"Blanc-Potard","year":"1997","journal-title":"EMBO J."},{"key":"2023033015235969500_cit-72","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1046\/j.1365-2958.2000.01797.x","article-title":"A parallel intraphagosomal survival strategy shared by Mycobacterium tuberculosis and","volume":"35","author":"Buchmeier","year":"2000","journal-title":"Salmonella enterica. Mol. Microbiol."},{"key":"2023033015235969500_cit-73","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1128\/IAI.73.5.3160-3163.2005","article-title":"Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment","volume":"73","author":"Lavigne","year":"2005","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-74","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1046\/j.1365-2958.2000.01794.x","article-title":"Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice","volume":"35","author":"Weber","year":"2000","journal-title":"Mol. Microbiol."},{"key":"2023033015235969500_cit-75","doi-asserted-by":"crossref","first-page":"9924","DOI":"10.1073\/pnas.0502767102","article-title":"The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages","volume":"102","author":"Sauer","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-76","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1365-2958.2005.04490.x","article-title":"Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5","volume":"55","author":"Wieland","year":"2005","journal-title":"Mol. Microbiol."},{"key":"2023033015235969500_cit-77","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1073\/pnas.94.3.934","article-title":"Bacterial infection as assessed by in vivo gene expression","volume":"94","author":"Heithoff","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-78","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2958.2003.03313.x","article-title":"Unraveling the biology of macrophage infection by gene expression profiling of intracellular","volume":"47","author":"Eriksson","year":"2003","journal-title":"Salmonella enterica. Mol. Microbiol."},{"key":"2023033015235969500_cit-79","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1084\/jem.20030846","article-title":"Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment","volume":"198","author":"Schnappinger","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-80","doi-asserted-by":"crossref","first-page":"14321","DOI":"10.1073\/pnas.2436197100","article-title":"Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients","volume":"100","author":"Timm","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-81","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1128\/IAI.73.6.3754-3757.2005","article-title":"Responses of Mycobacterium tuberculosis to growth in the mouse lung","volume":"73","author":"Dubnau","year":"2005","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-82","first-page":"637","article-title":"The effects of reactive nitrogen intermediates on gene expression in","volume":"5","author":"Ohno","year":"2003","journal-title":"Mycobacterium tuberculosis. Cell. Microbiol."},{"key":"2023033015235969500_cit-83","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1084\/jem.20030205","article-title":"Inhibition by nitric oxide induces a Mycobacterium tuberculosis dormancy program","volume":"198","author":"Voskuil","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-84","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1093\/emboj\/19.13.3235","article-title":"Salmonella maintains the integrity of its intracellular vacuole through the action of SifA","volume":"19","author":"Beuz\u00f3n","year":"2000","journal-title":"EMBO J."},{"key":"2023033015235969500_cit-85","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1128\/IAI.70.6.3264-3270.2002","article-title":"Disruption of the Salmonella-containing vacuole leads to increased replication of Salmonella enterica serovar Typhimurium in the cytosol of epithelial cells","volume":"70","author":"Brumell","year":"2002","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-86","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/345175a0","article-title":"Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells","volume":"345","author":"Bielecki","year":"1990","journal-title":"Nature"},{"key":"2023033015235969500_cit-87","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1128\/IAI.69.4.2753-2756.2001","article-title":"Secretion of listeriolysin by Brucella suis inhibits its intramacrophagic replication","volume":"69","author":"K\u00f6hler","year":"2001","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-88","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1462-5822.2001.00131.x","article-title":"Identification of Brucella spp. genes involved in intracellular trafficking","volume":"3","author":"Delrue","year":"2001","journal-title":"Cell. Microbiol."},{"key":"2023033015235969500_cit-89","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mib.2003.11.001","article-title":"Organelle robbery: Brucella interactions with the endoplasmic reticulum","volume":"7","author":"Celli","year":"2004","journal-title":"Curr. Opin. Microbiol."},{"key":"2023033015235969500_cit-90","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1128\/IAI.67.7.3199-3206.1999","article-title":"Survival of Mycobacterium avium and Mycobacterium tuberculosis in acidified vacuoles of murine macrophages","volume":"67","author":"Gomes","year":"1999","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-91","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1128\/IAI.68.8.4518-4522.2000","article-title":"Growth of Mycobacterium tuberculosis in a defined medium is very restricted by acid pH and Mg2+ levels","volume":"68","author":"Piddington","year":"2000","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-92","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ncb1036","article-title":"Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria","volume":"5","author":"Anes","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"2023033015235969500_cit-93","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1093\/emboj\/18.14.3924","article-title":"A Salmonella virulence protein that inhibits cellular trafficking","volume":"18","author":"Uchiya","year":"1999","journal-title":"EMBO J."},{"key":"2023033015235969500_cit-94","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1091\/mbc.e03-08-0614","article-title":"Dynein-mediated vesicle transport controls intracellular Salmonella replication","volume":"15","author":"Marsman","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"2023033015235969500_cit-95","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1084\/jem.184.4.1349","article-title":"The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrin","volume":"184","author":"Clemens","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-96","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1126\/science.273.5274.501","article-title":"A receptor for the selective uptake and degradation of proteins by lysosomes","volume":"273","author":"Cuervo","year":"1996","journal-title":"Science"},{"key":"2023033015235969500_cit-97","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0966-842X(01)02098-4","article-title":"Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions","volume":"9","author":"Forbes","year":"2001","journal-title":"Trends Microbiol."},{"key":"2023033015235969500_cit-98","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1242\/jcs.111.19.2855","article-title":"Localization of Nramp1 in macrophages: modulation with activation and infection","volume":"111","author":"Searle","year":"1998","journal-title":"J. Cell Sci."},{"key":"2023033015235969500_cit-99","first-page":"165","article-title":"Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance to","volume":"95","author":"Gomes","year":"1998","journal-title":"Mycobacterium avium. Immunology"},{"key":"2023033015235969500_cit-100","first-page":"1045","article-title":"Evidence inconsistent with a role for the Bcg gene (Nramp1) in resistance of mice to infection with virulent","volume":"183","author":"Medina","year":"1996","journal-title":"Mycobacterium tuberculosis. J. Exp. Med."},{"key":"2023033015235969500_cit-101","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1128\/IAI.67.11.5811-5814.1999","article-title":"Consequence of Nramp1 deletion to Mycobacterium tuberculosis infection in mice","volume":"67","author":"North","year":"1999","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-102","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.4049\/jimmunol.171.4.1994","article-title":"Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression","volume":"171","author":"Fritsche","year":"2003","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-103","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/jlb.67.4.501","article-title":"A negative autoregulatory link between Nramp1 function and expression","volume":"67","author":"Baker","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"2023033015235969500_cit-104","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1128\/IAI.69.11.6618-6624.2001","article-title":"Infection with Mycobacterium avium differentially regulates the expression of iron transport protein mRNA in murine peritoneal macrophages","volume":"69","author":"Zhong","year":"2001","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-105","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1128\/IAI.73.6.3577-3586.2005","article-title":"IFN\u03b3-induced T cell loss during infection by virulent","volume":"73","author":"Fl\u00f3rido","year":"2005","journal-title":"Mycobacterium avium. Infect. Immun."},{"key":"2023033015235969500_cit-106","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.4049\/jimmunol.153.11.5141","article-title":"TNF-\u03b1 and IFN-\u03b3 stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner","volume":"153","author":"Leenen","year":"1994","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-107","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1172\/JCI114038","article-title":"Interferon \u03b3-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron","volume":"83","author":"Byrd","year":"1989","journal-title":"J. Clin. Invest."},{"key":"2023033015235969500_cit-108","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1172\/JCI116318","article-title":"Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon \u03b3","volume":"91","author":"Byrd","year":"1993","journal-title":"J. Clin. Invest."},{"key":"2023033015235969500_cit-109","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.174.2.459","article-title":"Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity","volume":"174","author":"Alford","year":"1991","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-110","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1128\/iai.59.7.2274-2278.1991","article-title":"Iron limitation and the \u03b3 interferon-mediated antihistoplasma state of murine macrophages","volume":"59","author":"Lane","year":"1991","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-111","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1128\/iai.59.12.4684-4686.1991","article-title":"\u03b3 Interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: antimicrobial role of limiting intracellular iron","volume":"59","author":"Murray","year":"1991","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-112","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1126\/science.288.5471.1651","article-title":"Lack of a role for iron in the Lyme disease pathogen","volume":"288","author":"Posey","year":"2000","journal-title":"Science"},{"key":"2023033015235969500_cit-113","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jlb.62.2.277","article-title":"Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo","volume":"62","author":"Govoni","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"2023033015235969500_cit-114","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1073\/pnas.81.3.908","article-title":"Interferon \u03b3 blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan","volume":"81","author":"Pfefferkorn","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033015235969500_cit-115","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1128\/iai.57.3.845-849.1989","article-title":"Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of \u03b3 interferon-stimulated human macrophages","volume":"57","author":"Murray","year":"1989","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-116","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.4049\/jimmunol.150.12.5529","article-title":"IFN-\u03b3-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth","volume":"150","author":"Thomas","year":"1993","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-117","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0952-7915(02)00361-8","article-title":"The role of IFN-\u03b3 in the outcome of chlamydial infection","volume":"14","author":"Rottenberg","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"2023033015235969500_cit-118","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4049\/jimmunol.164.1.389","article-title":"Macrophage control of mycobacterial growth induced by picolinic acid is dependent on host cell apoptosis","volume":"164","author":"Pais","year":"2000","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-119","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0167-5699(99)01520-0","article-title":"Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?","volume":"20","author":"Mellor","year":"1999","journal-title":"Immunol. Today"},{"key":"2023033015235969500_cit-120","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1126\/science.291.5508.1544","article-title":"Induction of direct antimicrobial activity through mammalian Toll-like receptors","volume":"291","author":"Thoma-Uszynski","year":"2001","journal-title":"Science"},{"key":"2023033015235969500_cit-121","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.1096158","article-title":"Regulation of phagosome maturation by signals from Toll-like receptors","volume":"304","author":"Blander","year":"2004","journal-title":"Science"},{"key":"2023033015235969500_cit-122","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.immuni.2005.09.007","article-title":"Phagosome maturation proceeds independently of stimulation of Toll-like receptors 2 and 4","volume":"23","author":"Yates","year":"2005","journal-title":"Immunity"},{"key":"2023033015235969500_cit-123","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.4049\/jimmunol.169.7.3869","article-title":"MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity","volume":"169","author":"Edelson","year":"2002","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-124","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.4049\/jimmunol.160.3.1290","article-title":"Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages","volume":"160","author":"Schaible","year":"1998","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-125","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1242\/jcs.111.7.897","article-title":"Effects of cytokines on mycobacterial phagosome maturation","volume":"111","author":"Via","year":"1998","journal-title":"J. Cell Sci."},{"key":"2023033015235969500_cit-126","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1126\/science.1088063","article-title":"Immune control of tuberculosis by IFN-\u03b3-inducible LRG-47","volume":"302","author":"MacMicking","year":"2003","journal-title":"Science"},{"key":"2023033015235969500_cit-127","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1084\/jem.194.2.181","article-title":"Inactivation of LRG-47 and IRG-47 reveals a family of interferon \u03b3-inducible genes with essential, pathogen-specific roles in resistance to infection","volume":"194","author":"Collazo","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-128","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1128\/IAI.73.5.3166-3171.2005","article-title":"Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within \u03b3 interferon-activated macrophages","volume":"73","author":"Santic","year":"2005","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-129","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1084\/jem.170.6.2141","article-title":"\u03b3 Interferon limits access of Listeria monocytogenes to the macrophage cytoplasm","volume":"170","author":"Portnoy","year":"1989","journal-title":"J. Exp. Med."},{"key":"2023033015235969500_cit-130","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1099\/mic.0.26815-0","article-title":"Induction of Mycobacterium avium growth restriction and inhibition of phagosome-endosome interactions during macrophage activation and apoptosis induction by picolinic acid plus IFN\u03b3","volume":"150","author":"Pais","year":"2004","journal-title":"Microbiology"},{"key":"2023033015235969500_cit-131","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1093\/emboj\/19.13.3325","article-title":"The apoptotic signaling pathway activated by Toll-like receptor 2","volume":"19","author":"Aliprantis","year":"2000","journal-title":"EMBO J."},{"key":"2023033015235969500_cit-132","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1126\/science.285.5428.736","article-title":"Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor 2","volume":"285","author":"Aliprantis","year":"1999","journal-title":"Science"},{"key":"2023033015235969500_cit-133","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1128\/IAI.72.4.2067-2074.2004","article-title":"Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages","volume":"72","author":"Dao","year":"2004","journal-title":"Infect. Immun."},{"key":"2023033015235969500_cit-134","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.4049\/jimmunol.173.5.3320","article-title":"Signaling of apoptosis through TLRs critically involves Toll\/IL1 receptor domain-containing adapter-inducing IFN-\u03b2, but not MyD88, in bacteria-infected murine macrophages","volume":"173","author":"Ruckdeschel","year":"2004","journal-title":"J. Immunol."},{"key":"2023033015235969500_cit-135","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2004.11.038","article-title":"Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages","volume":"119","author":"Gutierrez","year":"2004","journal-title":"Cell"},{"key":"2023033015235969500_cit-136","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/sj.cdd.4401651","article-title":"Vitamin D analog EB1089 triggers dramatic lysosomal changes and beclin 1-mediated autophagic cell death","volume":"12","author":"Hoyer-Hansen","year":"2005","journal-title":"Cell Death Differ."},{"key":"2023033015235969500_cit-137","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1084\/jem.189.9.1425","article-title":"An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets","volume":"189","author":"Harth","year":"1999","journal-title":"J. Exp. Med."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/79\/6\/1117\/49643000\/jlb1117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/79\/6\/1117\/49643000\/jlb1117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T22:35:04Z","timestamp":1680215704000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/79\/6\/1117\/6922744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,7]]},"references-count":137,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,4,7]]},"published-print":{"date-parts":[[2006,4,7]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.0206079","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,6]]},"published":{"date-parts":[[2006,4,7]]}}}