{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:47:31Z","timestamp":1773798451635,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,6,15]],"date-time":"2007-06-15T00:00:00Z","timestamp":1181865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association pour la Recherche contre le Cancer"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Large B cell lymphomas can comprise numerous CD14+ cells in the tumor stroma, which raises the question of whether monocytes can support B cell survival and proliferation. We show that the coculture of monocytes with B cells from peripheral blood or from diffuse large B cell lymphoma enabled prolonged B cell survival. Under these conditions, diffuse large lymphoma B cells proliferated, and addition of B cell-activating factor of the TNF family (BAFF) and IL-2 enhanced cell division. Monocytes and dendritic cells (DC) had similar antiapoptotic activity on healthy B cells but displayed differences with respect to B cell proliferation. Monocytes and cord blood-derived CD14+ cells promoted B cell proliferation in the presence of an anti-CD40 stimulus, whereas DC supported B cell proliferation when activated through the BCR. DC and CD14+ cells were able to induce plasmocyte differentiation. When B cells were activated via the BCR or CD40, they released the leukocyte attractant CCL5, and this chemokine is one of the main chemokines expressed in diffuse large B cell lymphoma. The data support the notion that large B cell lymphoma recruit monocytes via CCL5 to support B cell survival and proliferation.<\/jats:p>","DOI":"10.1189\/jlb.0706481","type":"journal-article","created":{"date-parts":[[2007,6,16]],"date-time":"2007-06-16T11:59:17Z","timestamp":1181995157000},"page":"567-575","source":"Crossref","is-referenced-by-count":69,"title":["Critical role of monocytes to support normal B cell and diffuse large B cell lymphoma survival and proliferation"],"prefix":"10.1093","volume":"82","author":[{"given":"Chris G","family":"Mueller","sequence":"first","affiliation":[{"name":"INSERM, U872, Centre de Recherches Biom\u00e9dicales des Cordeliers Universit\u00e9 Pierre et Marie Curie (Paris VI) et Ren\u00e9 Descartes (Paris V) , UMR S 872, Paris , France"},{"name":"CNRS, Laboratory of Therapeutic Immunology and Chemistry, IBMC , Strasbourg , France"}]},{"given":"Charlotte","family":"Boix","sequence":"additional","affiliation":[{"name":"INSERM, U872, Centre de Recherches Biom\u00e9dicales des Cordeliers Universit\u00e9 Pierre et Marie Curie (Paris VI) et Ren\u00e9 Descartes (Paris V) , UMR S 872, Paris , France"}]},{"given":"Wing-Hong","family":"Kwan","sequence":"additional","affiliation":[{"name":"INSERM, U872, Centre de Recherches Biom\u00e9dicales des Cordeliers Universit\u00e9 Pierre et Marie Curie (Paris VI) et Ren\u00e9 Descartes (Paris V) , UMR S 872, Paris , France"}]},{"given":"C\u00e9cile","family":"Daussy","sequence":"additional","affiliation":[{"name":"INSERM, U872, Centre de Recherches Biom\u00e9dicales des Cordeliers Universit\u00e9 Pierre et Marie Curie (Paris VI) et Ren\u00e9 Descartes (Paris V) , UMR S 872, Paris , France"}]},{"given":"Emilie","family":"Fournier","sequence":"additional","affiliation":[{"name":"INSERM, U872, Centre de Recherches Biom\u00e9dicales des Cordeliers Universit\u00e9 Pierre et Marie Curie (Paris VI) et Ren\u00e9 Descartes (Paris V) , UMR S 872, Paris , France"}]},{"given":"Wolf H","family":"Fridman","sequence":"additional","affiliation":[{"name":"INSERM, U872, Centre de Recherches Biom\u00e9dicales des Cordeliers Universit\u00e9 Pierre et Marie Curie (Paris VI) et Ren\u00e9 Descartes (Paris V) , UMR S 872, Paris , France"}]},{"given":"Thierry J","family":"Molina","sequence":"additional","affiliation":[{"name":"Univrsit\u00e9 Paris-Descartes, Facult\u00e9 de M\u00e9decine, AP-HP, H\u00f4tel-Dieu, Service d\u2019Anatomie et de Cytologie Pathologiques , Paris , France"}]}],"member":"286","published-online":{"date-parts":[[2007,6,15]]},"reference":[{"key":"2023033006500973400_","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jlb.66.2.224","article-title":"Dendritic cells directly modulate B cell growth and differentiation","volume":"66","author":"Dubois","year":"1999","journal-title":"J. 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