{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:27:17Z","timestamp":1740893237479,"version":"3.38.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p> Background: Extracellular matrix degradation may play an important role in left ventricular (LV) remodeling. It has been reported that matrix metalloproteinase-2 (MMP-2) is activated under mechanical stress conditions. Therefore, we examined the release of MMP-2, its inhibitor and interleukin-6 (IL-6), which affects MMPs, in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). <\/jats:p><jats:p> Methods: Arterial blood samples were obtained from 20 patients undergoing cardiac surgery and six patients with descending aortic replacement (as noncardiac control) with CPB. Samples were assayed for plasma MMP-2, tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) and IL-6 concentration. <\/jats:p><jats:p> Results: Plasma MMP-2 concentrations in the valvular disease patients were greater than in other patients ( p &lt; 0.05) and correlated with the LV mass (r= 0.810, p &lt; 0.0001) prior to the operation. Plasma MMP-2 concentrations decreased during CPB and gradually recovered to the baseline levels after CPB. Plasma TIMP-2 concentrations increased significantly during and after CPB in a biphasic manner. Plasma IL-6 concentrations also increased significantly during CPB ( p &lt; 0.05 versus baseline levels). <\/jats:p><jats:p> Conclusion: Plasma MMP-2 concentrations reflect the state of the left ventricle, and changes in plasma MMP-2 and TIMP-2 concentrations during CPB may play an important role in LV remodeling after cardiac surgery. <\/jats:p>","DOI":"10.1191\/0267659102pf612oa","type":"journal-article","created":{"date-parts":[[2003,1,7]],"date-time":"2003-01-07T02:07:02Z","timestamp":1041905222000},"page":"435-439","source":"Crossref","is-referenced-by-count":4,"title":["Differential regulation of MMP-2, TIMP-2 and IL-6 in valve replacement versus                 CABG patients"],"prefix":"10.1177","volume":"17","author":[{"given":"Masazumi","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Tokyo Medical and                         Dental University, Tokyo, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Tokyo Medical and                         Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagahisa","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Tokyo Medical and                         Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Tokyo Medical and                         Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Tokyo Medical and                         Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sunamori","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Tokyo Medical and                         Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90360-4"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.8.1850705"},{"key":"atypb3","first-page":"729","volume":"76","author":"Robert V","year":"1997","journal-title":"Lab 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