{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:44:33Z","timestamp":1777607073583,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p> Objective: Acute respiratory failure is complicated by acidosis and altered end-organ perfusion. NOVA-LUNG\u00aeiLA is an interventional lung assist (ILA) device for arteriovenous carbon dioxide removal (AVCO<jats:sub>2<\/jats:sub>R). The present study was conducted to evaluate the device for short-term CO<jats:sub>2<\/jats:sub> removal performance and hemodynamic response. <\/jats:p><jats:p> Methods: Six adult sheep received cannulation of the jugular vein and carotid artery. The ILA-AVCO<jats:sub>2<\/jats:sub>R circuit was placed on the sheep for 72 hours. Hemodynamics and PaCO<jats:sub>2<\/jats:sub> were measured; CO<jats:sub>2<\/jats:sub> removal was calculated while varying sweep gas flow rates (Q<jats:sub>g<\/jats:sub>), device blood flow rates (Q<jats:sub>b<\/jats:sub>), and PaCO<jats:sub>2<\/jats:sub>. <\/jats:p><jats:p> Results: Hemo-dynamic variables remained normal throughout the 72 hour study. CO<jats:sub>2<\/jats:sub> removal increased with increases in Q<jats:sub>g<\/jats:sub>or Q<jats:sub>b<\/jats:sub>. Mean CO<jats:sub>2<\/jats:sub> removal was 119.3 ml\/min for Q<jats:sub>b<\/jats:sub> 1L\/min, Q<jats:sub>g<\/jats:sub> 5 L\/min, and PaCO<jats:sub>2<\/jats:sub> 40 - 50 mmHg.<jats:sub>PaCO<\/jats:sub>2 was directly proportional to CO<jats:sub>2<\/jats:sub> clearance (R-0.72, p B\/0.001). <\/jats:p><jats:p> Conclusion: NOVALUNG\u00aeiLA can provide near total CO<jats:sub>2<\/jats:sub> removal with Q<jats:sub>b<\/jats:sub> 1 - 2 L\/min,<jats:sub>Q<\/jats:sub>g 5 L\/min, and minimal flow resistance (3.889\/0.82 mmHg\/L\/min). PaCO<jats:sub>2<\/jats:sub> correlates with CO<jats:sub>2<\/jats:sub> removal and is dependent on Q<jats:sub>b<\/jats:sub> and Q<jats:sub>g<\/jats:sub>. <\/jats:p>","DOI":"10.1191\/0267659105pf838oa","type":"journal-article","created":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T23:26:51Z","timestamp":1131751611000},"page":"303-308","source":"Crossref","is-referenced-by-count":30,"title":["Seventy-two hour gas exchange performance and hemodynamic properties of                 NOVALUNG\u00aeiLA as a gas exchanger for arteriovenous carbon dioxide removal"],"prefix":"10.1177","volume":"20","author":[{"given":"Xiaoqin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Surgery, The University of Texas Medical Branch, Galveston,                         Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B","family":"Loran","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Texas Medical Branch, Galveston,                         Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Texas Medical Branch, Galveston,                         Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brannon R","family":"Hyde","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Texas Medical Branch, Galveston,                         Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D","family":"Lick","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Texas Medical Branch, Galveston,                         Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B","family":"Zwischenberger","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Texas Medical Branch, Galveston,                         Texas, 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