{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:57:21Z","timestamp":1791064641654,"version":"4.1.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p> Objectives: To study the clinical presentation and natural history of radiationinduced brachial plexopathy in 33 women treated for carcinoma of the breast. <\/jats:p><jats:p> Methods: All of the patients were referred to a single consultant neurologist. Details of surgical procedures, radiotherapy, symptoms at presentation and follow-up and neurological \u201dndings were recorded. Patients were reviewed at six or 12 monthly intervals for 2\u201319 years (median 9.5 years). Investigations included blood tests, chest X-ray, bone scan, neurophysiological studies, computerized tomography (CT) or magnetic resonance imaging (MRI) of the cervical spine and cerebrospinal \u2018uid examination. <\/jats:p><jats:p> Results: Symptoms began from six months to 20 years after radiotherapy (median time 1.5 years). Progressive weakness was universal and resulted in loss of any useful hand function in all but three patients. The time taken to loss of useful hand function ranged from six weeks to \u201dve years (median 1.25 years). Three patterns of upper limb weakness were identi\u201ded, distal limb weakness only (13 patients), global limb weakness that was more marked distally (11 patients), and completely \u2018accid arm (10 patients). Seventeen patients required long-term morphine to palliate pain. A chemical sympathectomy beneted three patients. <\/jats:p><jats:p> Conclusions: Most patients developed symptoms within three years, but late presentations 8\u201320 years later were encountered. Symptoms were progressive in all patients, though the rate did vary. Pain was common and persisted inde\u201dnitely in all but one patient. Morphine was effective and should be used early and in adequate doses. Chemical sympathectomy provided sustained relief in three of six patients. <\/jats:p>","DOI":"10.1191\/0269215502cr470oa","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:37:23Z","timestamp":1027773443000},"page":"160-165","source":"Crossref","is-referenced-by-count":90,"title":["Radiation-induced brachial plexopathy in women treated for carcinoma of the breast"],"prefix":"10.1177","volume":"16","author":[{"given":"Edward","family":"Fathers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Thrush","sequence":"additional","affiliation":[{"name":"Department of Neurology, Derriford Hospital, Plymouth, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Huson","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Oxford Radcliffe Hospital Trust, The Churchill, Oxford, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Norman","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit, Birmingham Women's Hospital, Edgbaston, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90895-O"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90256-2"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90771-U"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891201)64:11<2217::AID-CNCR2820641106>3.0.CO;2-2"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90171-Q"},{"key":"atypb6","volume-title":"Report of the independent review commissioned by the Royal College of Radiologists into brachial plexus neuropathy following radiotherapy for breast cancer","author":"Bates T","year":"1995"},{"key":"atypb7","first-page":"228","volume":"14","author":"Svensson H","year":"1975","journal-title":"Acta Radiol (Oncol)"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511213132128"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1972.03210110032008"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5491.834"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.1.45"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.10.1331"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.4.502"}],"container-title":["Clinical Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0269215502cr470oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0269215502cr470oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T18:19:18Z","timestamp":1740853158000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0269215502cr470oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1191\/0269215502cr470oa"],"URL":"https:\/\/doi.org\/10.1191\/0269215502cr470oa","relation":{},"ISSN":["0269-2155","1477-0873"],"issn-type":[{"value":"0269-2155","type":"print"},{"value":"1477-0873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}