{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:48:42Z","timestamp":1791179322342,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p> Objectives: To assess the effectiveness of sensory stimulation programmes in patients in coma or vegetative state. <\/jats:p><jats:p> Design: Systematic review of randomized control trials (RCT) and nonrandomized controlled clinical trials (CCT) comparing any type of stimulation programmes with standard rehabilitation in patients in coma or vegetative state. The Injuries Group specialized register, the Cochrane Controlled trial register, EMBASE, MEDLINE, CINAHL, PSYCHLIT from 1966 to January 2002 were searched without language restriction. Reference lists of articles were scanned and experts in the area contacted to \u201dnd other relevant studies. Abstracts and papers found were initially screened by one reviewer. Three reviewers independently identi\u201ded relevant studies, extracted data and assessed study quality, resolving disagreement by consensus. <\/jats:p><jats:p> Outcome measures: Duration of unconsciousness (including coma and vegetative state) de\u201dned as the time between trauma and objective recovery of the ability to respond to verbal commands; level of consciousness, as measured by the Glasgow Coma Scale (GCS); level of cognitive functioning (LCF); functional outcomes, as measured by Glasgow Outcome Scale (GOS) or by Disability Rating Scale; negative effects (e.g. increased intracranial pressure). <\/jats:p><jats:p> Results: Three studies (one RCT and two CCTs) with 68 traumatic brain-injured patients in total, most of whom were road accident victims, met the inclusion criteria. The overall methodological quality was poor and studies differed widely in terms of study design and conduct. Moreover, due to the diversity in reporting of outcome measures, a quantitative metanalysis was not possible. None of the three studies provided useful and valid results on outcomes of clinical relevance for coma patients. <\/jats:p>","DOI":"10.1191\/0269215502cr519oa","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:10Z","timestamp":1033509850000},"page":"464-472","source":"Crossref","is-referenced-by-count":103,"title":["Sensory stimulation of brain-injured individuals in coma or vegetative state: results of a Cochrane systematic review"],"prefix":"10.1177","volume":"16","author":[{"given":"Francesco","family":"Lombardi","sequence":"first","affiliation":[{"name":"UO di Riabilitazione Intensiva, Ospedale di Correggio, AUSL Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Taricco","sequence":"additional","affiliation":[{"name":"Dipartimento di Riabilitazione, Azienda Ospedaliera \u2018G Salvini\u2019, Passirana di Rho, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Tanti","sequence":"additional","affiliation":[{"name":"UO Gravi Cerebrolesioni e Disturbi Cognitivi, Villa Beretta, Costamasnaga, Lecco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Telaro","sequence":"additional","affiliation":[{"name":"Centro Cochrane Italiano, Istituto \u2018Mario Negri\u2019, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Liberati","sequence":"additional","affiliation":[{"name":"Centro Cochrane Italiano, Istituto \u2018Mario Negri\u2019, Milan and Dipartimento Scienze Igienistiche, Universit\u00e0 di Modena e Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530180032013"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406023302206"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.4.407"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91543-X"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.3109\/02699059109008113"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-1991-1304"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1080\/026990596123918"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-199708000-00008"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3109\/02699059009026177"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.3109\/02699059109008112"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1080\/09602019308401436"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.3109\/02699059209008137"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(95)80031-X"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"atypb15","volume-title":"Rehabilitation of the head injured adult. 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