{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:34:49Z","timestamp":1791092089510,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p> Objective: To study the efficacy of cognitive rehabilitation combined with acetylcholinesterase inhibitor (AChE-I) treatment in patients with mild Alzheimer's disease and their relatives. <\/jats:p><jats:p> Method: Thirteen patients with mild Alzheimer's disease treated with rivastigmine 6-12 mg\/day for more than two months started cognitive rehabilitation training. Before and after the cognitive rehabilitation training patients were assessed through cognitive tests, activities of daily living scale, neuropsychological battery and scales to evaluate caregivers' depressive and anxiety symptoms. Six patients were randomized to a combined treatment group (AChE-I plus cognitive rehabilitation and caregiver support) and seven patients to a control group (AChE-I only) and followed up for five months. <\/jats:p><jats:p> Results: Mini-Mental State Examination (MMSE) scores (p=0.047) and backward digit span scores (p=0.018) were significantly different between the groups on follow-up. The combined treatment group showed a better positive treatment effect on cognitive and neuropsychological tests applied to patients and reduction of psychiatric symptoms was observed in their caregivers (nonsignificant). <\/jats:p><jats:p> Conclusion: Cognitive rehabilitation associated with AChE-I treatment can potentially be useful to stabilize or improve cognitive and functional performance of patients with mild Alzheimer's disease and can reduce caregivers' psychiatric symptoms. <\/jats:p>","DOI":"10.1191\/0269215505cr911oa","type":"journal-article","created":{"date-parts":[[2005,10,29]],"date-time":"2005-10-29T23:04:59Z","timestamp":1130627099000},"page":"861-869","source":"Crossref","is-referenced-by-count":95,"title":["Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients: a pilot study"],"prefix":"10.1177","volume":"19","author":[{"given":"C\u00e1ssio MC","family":"Bottino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel AM","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria MA","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Avila","sequence":"additional","affiliation":[{"name":"Old Age Research Group (PROTER), Department and Institute of Psychiatry, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia R","family":"Zukauskas","sequence":"additional","affiliation":[{"name":"Department of Experimental Physiopathology, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia EZ","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via C","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio R","family":"Hototian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Saffi","sequence":"additional","affiliation":[{"name":"Old Age Research Group (PROTER), Department and Institute of Psychiatry, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e3ndida HP","family":"Camargo","sequence":"additional","affiliation":[{"name":"Neuropsychology and Psychology Section, Institute of Psychiatry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617797004876"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb04461.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/gps.428"},{"key":"atypb4","first-page":"510","volume-title":"Clinical geriatric psychopharmacology","author":"Schneider L","year":"1998"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7184.633"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199711030-00005"},{"issue":"4","key":"atypb7","first-page":"S213","volume":"19","author":"De Vreese","year":"1998","journal-title":"Neurobiol Aging"},{"key":"atypb8","unstructured":"8 Organiza\u00e7\u00e3o Mundial da Sa\u00fade. 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