{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:46:53Z","timestamp":1792036013766,"version":"4.4.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p> This multicentre, observational study examined the efficacy of the therapeutic transdermal fentanyl system (TTS-fentanyl) in children requiring opioids for pain in life-threatening disease. Forty-one children receiving oral morphine (median dose 60 mg\/day) transferred to transdermal fentanyl (median dose 25 g\/h according with the manufacturer's dose conversion guidelines). Twenty-six children completed the 15-day treatment phase, seven died due to disease progression and eight were withdrawn because of adverse events, inadequate analgesia or a change to parenteral opioids. After 15 days, the median fentanyl dose was 75 g\/h (range 25\u2013250). No serious adverse events were attributed to fentanyl. There was a trend toward improved side-effects and convenience with fentanyl. Twenty-three of 26 parents (three missing) and 25 of 26 investigators considered transdermal fentanyl to be better than previous treatment. For all records available (at 15 days or on withdrawal if earlier), 75% (27\/36) reported that fentanyl treatment was \u2018good' or \u2018very good\u2019. The findings suggest that transdermal fentanyl is both effective and acceptable for children and their families. <\/jats:p>","DOI":"10.1191\/026921601680419456","type":"journal-article","created":{"date-parts":[[2003,5,7]],"date-time":"2003-05-07T23:18:25Z","timestamp":1052349505000},"page":"405-412","source":"Crossref","is-referenced-by-count":48,"title":["Transdermal fentanyl for pain relief in a paediatric palliative care population"],"prefix":"10.1177","volume":"15","author":[{"given":"Anne","family":"Hunt","sequence":"first","affiliation":[{"name":"Institute of Child Health, London; RCN Institute, Radcliffe Infirmary, Woodstock Road, Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Goldman","sequence":"additional","affiliation":[{"name":"Institute of Child Health, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Devine","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Department, Royal Marsden Hospital, Sutton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology\/Oncology, Llandough Hospital, Penarth, on behalf of FEN-GBR-14 Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/026921639000400405"},{"key":"atypb2","volume-title":"Cancer pain relief and palliative care in children","author":"World Health Organisation","year":"1998"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70457-9"},{"key":"atypb4","first-page":"387","volume-title":"Advances in pain research and therapy","author":"McGrath PA","year":"1985"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871001)60:7<1651::AID-CNCR2820600738>3.0.CO;2-J"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6678.937"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.6.641"},{"key":"atypb8","first-page":"63","volume":"1","author":"Brady M","year":"1999","journal-title":"CME Bulletin Palliat Med"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1007\/BF03015333"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70326-4"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.3109\/08880019209016603"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(97)00082-1"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(97)00361-8"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70370-5"}],"container-title":["Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/026921601680419456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/026921601680419456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T02:41:59Z","timestamp":1740883319000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/026921601680419456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1191\/026921601680419456"],"URL":"https:\/\/doi.org\/10.1191\/026921601680419456","relation":{},"ISSN":["0269-2163","1477-030X"],"issn-type":[{"value":"0269-2163","type":"print"},{"value":"1477-030X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}