{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:55:26Z","timestamp":1785815726355,"version":"3.56.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p> Purpose: To assess the prevalence of vitamin C deficiency within a group of hospice patients. To assess the relationship between plasma vitamin C, dietary intake and subsequent survival. Methods: Patients with advanced cancer were recruited from a large hospice. Data were collected on demographic details, physical functioning and smoking history. An estimate was obtained of the number of weekly dietary portions consumed equivalent to 40 mg of vitamin C, the recommended daily intake. Plasma vitamin C was measured by a single blood sample. The study had local ethical approval. Results: Fifty patients were recruited (mean age 65.2 years, 28 female). Plasma vitamin C deficiency was found in 15 (30%). Dietary intake of vitamin C was correlated to plasma vitamin C (r=0.518, PB0.0001). Low dietary intake, low albumin, high platelet count, high CRP level and shorter survival were all significantly associated with low plasma vitamin C concentrations (B11 \u03bcmol\/L). There was no correlation between plasma vitamin C, smoking history or physical functioning. Conclusion: Vitamin C deficiency is common in patients with advanced cancer and the most important factors determining plasma levels are dietary intake and markers of the inflammatory response. Patients with low plasma concentrations of vitamin C have a shorter survival. <\/jats:p>","DOI":"10.1191\/0269216305pm970oa","type":"journal-article","created":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T00:29:40Z","timestamp":1104971380000},"page":"17-20","source":"Crossref","is-referenced-by-count":165,"title":["Vitamin C deficiency in cancer patients"],"prefix":"10.1177","volume":"19","author":[{"given":"Catriona R","family":"Mayland","sequence":"first","affiliation":[{"name":"St Gemma's Hospice, Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I","family":"Bennett","sequence":"additional","affiliation":[{"name":"St Gemma's Hospice, Harrogate Road, Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Allan","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Leeds Teaching Hospitals, Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"atypb1","first-page":"3373","volume-title":"Oxford textbook of medicine","author":"Hoffbrand AV","year":"1996"},{"key":"atypb2","first-page":"1228","volume-title":"Cecil textbook of medicine","author":"Rivlin RS","year":"1988"},{"key":"atypb3","first-page":"117","volume-title":"Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy","author":"Department of Health","year":"1991"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03350300093027"},{"key":"atypb5","first-page":"573","volume-title":"Oxford textbook of palliative medicine","author":"Neuenschwander H","year":"1998"},{"key":"atypb6","first-page":"198","volume-title":"Clinical medicine","author":"Clark ML","year":"1998"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7145.1661"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb05056.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7273.1381"},{"key":"atypb10","unstructured":"McCance RA                 ,                      Widdowson EM                 . The composition of foods, fifth edition (revised                 and extended).                      London: Royal Society of Chemistry                 , 1991."},{"key":"atypb11","first-page":"166","volume":"66","author":"Tessier F","year":"1996","journal-title":"Int J Vitam Nutr Res"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/120.suppl_11.1480"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1258\/0004563001899429"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/63.5.760"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197909273011303"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120301"}],"container-title":["Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0269216305pm970oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0269216305pm970oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T10:19:36Z","timestamp":1740824376000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0269216305pm970oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1191\/0269216305pm970oa"],"URL":"https:\/\/doi.org\/10.1191\/0269216305pm970oa","relation":{},"ISSN":["0269-2163","1477-030X"],"issn-type":[{"value":"0269-2163","type":"print"},{"value":"1477-030X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}