{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:32:10Z","timestamp":1777667530188,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>1 Trichloroethylene (TCE) is an organic unsaturated solvent used in dry cleaning, metal degreasing, thinner for paints\/varnishes, anaesthetic agents etc. Human beings are considerably exposed to TCE vapours by inhalation route. 2 TCE has been reported to induce spontaneous abor- tions and congenital cardiac malformation in occupa- tionally exposed women. However, scanty on-line information is available regarding toxic effects of TCE on male reproductive efficiency in experimental animals. 3 Our earlier observations with TCE inhalation in male rats (376 p.p.m., 4 h\/day, 5 days a week) for 12 and 24 weeks using whole body dynamic inhalation chamber consistently showed significant decrease (P&lt; 0.05) in total epididymal sperm count and sperm motility. The mating experiments of above TCE inhaled rats with virgin unexposed females showed significantly de- creased fertility. 4 These observations prompted us to investigate whether or not primary testicular steroidal precursors (choles- terol and ascorbic acid) and testosterone have any role in TCE induced significantly decreased epididymal sperm count, sperm motility and overall male repro- ductive inefficiency resulting therefrom. 5 The results indicate significant decrease (P&lt; 0.05) in total epididymal sperm count, sperm motility, specific activities of enzymes Glucose 6-p dehydrogenase (G6PDH) and 17,B hydroxy steroid dehydrogenase (1 7fHSD) with concomitant decrease in serum testos- terone concentrations in TCE inhaled rats showing reduced male reproductive efficiency. There was net accumulation in total cholesterol contents in testes of TCE exposed rats. 6 The findings in the present study indicate possible impairment of testosterone biosynthesis in TCE in- haled rats after 12 and 24 weeks. These findings also serve in parts to elucidate the mechanism of repro- ductive inefficiency in TCE exposed rats. The role of testosterone in this phenomenon is being reported for the first time.<\/jats:p>","DOI":"10.1191\/096032700678815657","type":"journal-article","created":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T19:38:43Z","timestamp":1049398723000},"page":"117-121","source":"Crossref","is-referenced-by-count":18,"title":["Steroidogenic alterations in testes and sera of rats exposed to                 trichioroethylene (TCE) by inhalation"],"prefix":"10.1177","volume":"19","author":[{"given":"P","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K K","family":"Dutta","sequence":"additional","affiliation":[{"name":"Inhalation ToxicologyLaboratoryandAnimalHouse (Gheru Campus), Industrial                         ToxicologyResearch Centre, P.O. Box 80, MG Marg, Lucknow-226001 (UP) India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,2,1]]},"reference":[{"key":"atypb1","volume-title":"Agency for Toxicity Substances Disease Registry","author":"Toxicology profile for Trichloroethylene. 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