{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:29:49Z","timestamp":1789622989211,"version":"build-2803163510"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p>\n                    A number of alkylphenolic compounds are used in a variety of commercial products and have been shown in in vitro studies to be weakly estrogenic, but few in vivo data are available addressing this issue in mammals. Human ex-posure to alkylphenols may occur not only from these environmental contaminants but also through contact with manufactured and metabolic breakdown products. The reproductive function of rats treated subcutaneously with nonylphenol (NP, 500 mg\/kg\/day) or 17Q3-estradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    , 2 mg\/kg\/day) as a positive control, from postnatal days 1 to 5 was examined after puberty. In addition, masculine sexual behavior, sperm motion, plasma testosterone concentration and histopathological changes in the reproductive organs of the rats were examined. Furthermore, male rats were subjected to an open field test and wheel cage test to evaluate locomotor activity, and the estrous cycle was examined in female rats. All male and female rats exposed neonatally to NP or E\n                    <jats:sub>2<\/jats:sub>\n                    showed macroscopic and\/or microscopic altera-tions of the gonads. Females treated with NP or E\n                    <jats:sub>2<\/jats:sub>\n                    showed an altered estrous cycle and abnormal reproductive function, while males treated with NP or E\n                    <jats:sub>2<\/jats:sub>\n                    showed normal reproduc-tion. In males exposed neonatally to NP or E\n                    <jats:sub>2<\/jats:sub>\n                    , no abnorm-alities were observed in locomotor activity, sperm motion or plasma testosterone concentration. The results of this study indicate that early neonatal exposure to NP causes dysfunc-tion of postpubertal reproductive function in female rats, as well as disrupted development of gonads in male and female rats. More detailed studies are warranted to assess the possible risks to human and wildlife reproduction from exposure to NP and other environmental chemicals with estrogenic activity.\n                  <\/jats:p>","DOI":"10.1191\/096032700678815909","type":"journal-article","created":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T19:38:43Z","timestamp":1049398723000},"page":"284-296","source":"Crossref","is-referenced-by-count":42,"title":["Disruption of the reproductive system and reproductive performance by                 administration of nonyiphenol to newborn rats"],"prefix":"10.1177","volume":"19","author":[{"given":"T","family":"Nagao","sequence":"first","affiliation":[{"name":"Department of Reproductive and Developmental Toxicology, Hatano Research                         Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano, Kanagawa                         257-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Usumi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hatano Research Institute, Food and Drug Safety                         Center, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nakagomi","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Hatano Research Institute, Food and                         Drug Safety Center, Kanagawa, Japan; Ina Research Institute Inc., Chemical                         Analysis Dept., 2148 Nishiminowa, Ina, Nagano 399-4501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hatano Research Institute, Food and Drug Safety                         Center, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Reproductive and Developmental Toxicology, Hatano Research                         Institute, Food and Drug Safety Center, Kanagawa,,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"atypb1","first-page":"801","volume-title":"Encyclopedia of Chemical Technology","author":"Platt AE","year":"1978","edition":"3"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1021\/es60098a009"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02635812"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1080\/03067319208027027"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1021\/ac00107a008"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1080\/02652038609373575"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0269-7491(93)90096-7"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0166-445X(93)90064-8"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9192167"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/s001289900196"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.93101378"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90953-E"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.93101372"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1007\/BF02986921"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.95103346"},{"key":"atypb16","first-page":"68","volume":"2","author":"Muller AMF","year":"1995","journal-title":"Toxicology and Ecotoxicology News"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.951031136"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.2.267"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.2.255"},{"key":"atypb20","first-page":"179","volume-title":"Tamoxifen: Beyond the Antiestrogen","author":"Iguchi T","year":"1995"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(99)00017-9"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-83797-5"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(68)90078-4"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90198-9"},{"key":"atypb25","volume-title":"Nonparametric Statistics for the Behavioral Sciences","author":"Siegel S","year":"1956"},{"key":"atypb26","volume-title":"Principles and Procedures of Statistics","author":"Steel RGD","year":"1960"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.2307\/2528490"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:9:1:105"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1999.tb00568.x"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.61.288"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340105"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0198"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/52.1.80"},{"key":"atypb34","first-page":"142","volume":"36","author":"Fennell TR","year":"1997","journal-title":"Toxicologist"},{"key":"atypb35","first-page":"213","volume":"42","author":"Fennell TR","year":"1998","journal-title":"Toxicologist"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/S1382-6689(98)00009-X"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1016\/S1382-6689(98)00015-5"},{"key":"atypb38","first-page":"115","volume":"25","author":"Petrick G","year":"1992","journal-title":"Zeitschrift fur Wasser und Abwasser Forschung"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1997.1154"},{"key":"atypb40","volume-title":"Final Report on the Reproductive Toxicity of Nonylphenol: Administered by Gavage to Sprague-Dawley Rats, Technical Report, September 2, 1997, RACB94012","author":"NTP","year":"1997"},{"key":"atypb41","first-page":"143","volume":"44","author":"Biegel LB","year":"1998","journal-title":"Toxicological Sciences"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(98)00037-9"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1037\/h0034673"}],"container-title":["Human &amp; 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