{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:18:36Z","timestamp":1789813116594,"version":"4.0.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>A 47-year-old Japanese woman undergoing maintenance hemodialysis (HD) was admitted to our hospital because of poisoning with the herbicide bialaphos. Respiratory arrest and loss of consciousness ensued rapidly, accompanied by convulsions and nystagmus. Treatment with HD and direct hemoperfusion, followed by HD alone, effectively removed bialaphos and its chief toxic metabolite (L-AMPB) from the circulation (bialaphos decreased from 0.33 to &lt;0.05 g\/ml andL-AMPBfrom14to0.86 g\/ml). The glutamate concentration improved gradually after the removal of bialaphos and L-AMPB from plasma (plasma glutamate concentration: 250.4 nmol\/l on day 5 to 120.6 nmol\/l on day 26). Decreased glutamine concentration in cerebrospinal fluidwasdemonstratedforthefirsttimeaswellasinplasma, indicating glutaminesynthetase inhibition notonlyinplants but also in humans by bialaphos poisoning.<\/jats:p>","DOI":"10.1191\/096032701682692973","type":"journal-article","created":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T19:38:43Z","timestamp":1049398723000},"page":"429-434","source":"Crossref","is-referenced-by-count":19,"title":["Decreased plasma and cerebrospinal fluid glutamine concentrations in a                 patient with bialaphos poisoning"],"prefix":"10.1177","volume":"20","author":[{"given":"T","family":"Ohtake","sequence":"first","affiliation":[{"name":"Department of Medicine, Fujinomiya City General Hospital, 3-1,                         Nishiki-cho Fujinomiya 418-0076, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Yasuda","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Hamamatsu University 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