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The present study has been undertaken to investigate whether TCE inhalation may also bring about testicular toxic effects. Our results indicate that inhalation of TCE by male rats for 12 and 24 weeks brings about significant reduction in absolute testicular weight, and alters marker testicular enzymes activity associated with spermatogenesis and germ cell maturation, along with marked histopathological changes showing depletion of germs cells and spermatogenic arrest.<\/jats:p>","DOI":"10.1191\/096032701718620882","type":"journal-article","created":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T19:38:43Z","timestamp":1049398723000},"page":"585-589","source":"Crossref","is-referenced-by-count":13,"title":["Trichloroethylene induced testicular toxicity in rats exposed by inhalation"],"prefix":"10.1177","volume":"20","author":[{"given":"P","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A K","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B K","family":"Maji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K K","family":"Dutta","sequence":"additional","affiliation":[{"name":"Inhalation Toxicology Division and Animal House, Industrial Toxicology                         Research Centre, Post Box 80, MG Marg, Lucknow 226001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"atypb1","first-page":"745","volume-title":"Kirk\u2014Othmer encyclopedia of chemical technology","author":"Mc Neill WC Jr","year":"1979"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114815"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(96)00058-5"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(89)90043-2"},{"key":"atypb5","volume-title":"Toxicology profile for trichloroethylene","year":"1995"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1191\/096032700678815657"},{"key":"atypb7","first-page":"177","volume":"26","author":"Dutta KK","year":"1982","journal-title":"Indian J Exp Biol"},{"key":"atypb8","volume-title":"Staining methods. 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