{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:35:31Z","timestamp":1777667731453,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>Oral administration of sodium fluoride (40 mg\/kg body weight) from day 6 to 19 of gestation caused, as compared to control, significant reductions in body weight, feed consumption, absolute uterine weight and number of implantations. Significantly higher incidence of skeletal (wavy ribs, 14th rib, &lt;6 sternal centre, dumbell-shaped second and fifth sternebrae, incomplete ossification of skull and thickening of tibia) and visceral (subcutaneous haemorrhage) abnormalities were also observed in NaF-treated dams than that of control. Oral administration of vitamin C (50 mg\/kg body weight) and vitamin E (2 mg\/0.2 ml olive oil\/animal\/day) from day 6 to 19 of gestation along with NaF significantly ameliorates NaF-induced reductions in body weight, feed consumption, absolute uterine weight (only with vitamin E treatment) and number of implantations. As compared with NaF-treated alone, the total percentage of skeletal and visceral abnormalities were significantly lowered in fluoride plus vitamin C-treated animals. Vitamin E was less effective. These findings suggest that vitamin C significantly reduced the severity and incidence of fluoride-induced embryotoxicity in rats.<\/jats:p>","DOI":"10.1191\/096032701718890559","type":"journal-article","created":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T19:38:43Z","timestamp":1049398723000},"page":"619-623","source":"Crossref","is-referenced-by-count":24,"title":["Vitamin C ameliorates fluoride-induced embryotoxicity in pregnant rats"],"prefix":"10.1177","volume":"20","author":[{"given":"R J","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Zoology, University School of Sciences, Gujarat University,                         Ahmedabad 380 009, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M Guna","family":"Sherlin","sequence":"additional","affiliation":[{"name":"Jai Research Foundation, Vapi, Valvada 396 108, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,12,1]]},"reference":[{"key":"atypb1","first-page":"43","volume":"31","author":"Rzeuski R","year":"1998","journal-title":"Fluoride"},{"key":"atypb2","first-page":"171","volume":"6","author":"Chinoy NJ","year":"1998","journal-title":"Environ Sci"},{"key":"atypb3","first-page":"81","volume":"31","author":"Wilde LG","year":"1998","journal-title":"Fluoride"},{"key":"atypb4","first-page":"20","volume":"29","author":"Zang ZY","year":"1996","journal-title":"Fluoride"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1996.tb03536.x"},{"key":"atypb6","first-page":"203","volume":"31","author":"Chinoy NJ","year":"1998","journal-title":"Fluoride"},{"key":"atypb7","first-page":"27","volume":"9","author":"Guna Sherlin DM","year":"1999","journal-title":"Indian J Environ Toxicol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1258\/002367768781082834"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3109\/10520292609115636"},{"key":"atypb10","first-page":"24","volume":"15","author":"Saralakumari D","year":"1988","journal-title":"Arogya J Health Sci"},{"key":"atypb11","first-page":"12","volume":"7","author":"Patel D","year":"1997","journal-title":"Indian J Environ Toxicol"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(95)00066-B"},{"key":"atypb13","first-page":"223","volume":"26","author":"Zhang ZY","year":"1993","journal-title":"Fluoride"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1080\/15287399409531866"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/096032719401300302"},{"key":"atypb16","volume-title":"Hum Exp Toxicol","author":"Guna Sherlin DM","year":"2000"},{"key":"atypb17","first-page":"1","volume":"11","author":"Malhotra A","year":"1993","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00003086-198307000-00038","volume":"177","author":"Vigorita VJ","year":"1983","journal-title":"Clin Orthop"},{"key":"atypb19","volume-title":"Proceedings XXth conference of the International Society of Fluoride Research","author":"Wang ZC"},{"key":"atypb20","first-page":"125","volume":"27","author":"Li J","year":"1994","journal-title":"Fluoride"},{"key":"atypb21","first-page":"298","volume":"70","author":"Susheela AK","year":"1999","journal-title":"Curr Sci"},{"key":"atypb22","unstructured":"Basu TK                 ,                      Dickerson JW                 .                      Vitamin C                 . In Vitamins in human health and disease.                      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