{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:38:58Z","timestamp":1777667938237,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>Ingestion of medicated oils containing methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning. In this retrospective study of 24 adults who had ingested \u2018White Flower Oil\u2019 (n=18) or \u2018Red Flower Oil\u2019 (n=6), the main objective was to determine if the risk of severe salicylate poisoning was related to the product packaging. \u2018Red Flower Oil\u2019 had a large bottle opening so that its content could be emptied much more easily. It also had a larger bottle size and usually had a higher methyl salicylate concentration than \u2018White Flower Oil\u2019. Patients tended to ingest a greater amount of \u2018Red Flower Oil\u2019 than \u2018White Flower Oil\u2019. Five per cent of subjects who had taken \u2018White Flower Oil\u2019, but 67% of subjects who had taken \u2018Red Flower Oil\u2019, had admission plasma salicy-late level \u22652.2 mmol\/L (P=0.006). None of the subjects who had ingested \u2018White Flower Oil\u2019, but 50% of subjects who had taken \u2018Red Flower Oil\u2019, had moderate to severe symptoms (P=0.010). As a result, none of the subjects who had ingested \u2018White Flower Oil\u2019, but 33% of subjects who had taken \u2018Red Flower Oil\u2019, required urine alkalinization (P=0.054). One patient who had taken \u2018Red Flower Oil\u2019 died because of hospital-acquired pneumonia. All other patients made a complete recovery. To reduce the amount of methyl salicylate that can be readily swallowed during accidental or deliberate ingestion of medicated oils, improvements are needed in the existing packaging of these products.<\/jats:p>","DOI":"10.1191\/0960327102ht240oa","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T16:07:41Z","timestamp":1034352461000},"page":"171-174","source":"Crossref","is-referenced-by-count":10,"title":["Ingestion of medicated oils by adults: the risk of severe salicylate                 poisoning is related to the packaging of these products"],"prefix":"10.1177","volume":"21","author":[{"given":"T YK","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine and                         Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital,                         Shatin, New Territories, Hong Kong, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.72.844.109"},{"key":"atypb2","first-page":"215","volume":"35","author":"Malik AS","year":"1994","journal-title":"Singapore Med J"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(98)70249-5"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1191\/096032700678816142"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.1997.10375103.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1995.tb00583.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6352.1383"},{"key":"atypb8","first-page":"317","volume":"26","author":"Johnson PN","year":"1984","journal-title":"Vet Hum Toxicol"},{"key":"atypb9","first-page":"207","volume":"132","author":"Davison C","year":"1961","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0960327102ht240oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0960327102ht240oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:48:22Z","timestamp":1777448902000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0960327102ht240oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1191\/0960327102ht240oa"],"URL":"https:\/\/doi.org\/10.1191\/0960327102ht240oa","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}