{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:39:09Z","timestamp":1777667949371,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>Aims: The study was designed to investigate the acute effects of ingested tetrahydrocannabinol (THC) on auditory function. Methods: Eight male subjects (aged 22\u201330 years), who had previous experience of cannabis use, took part in this study. They performed air conduction pure tone audiometry in both ears over 0.5\u20138 kHz. A simple test of frequency selectivity by detecting a 4-kHz tone under two masking noise conditions was also carried out in one ear. Three test sessions at weekly intervals were carried out, at the start of which they ingested a capsule containing either placebo, or 7.5 or 15 mg of THC. These were administered in a randomized cross-over, double-blind manner. Auditory testing as described above was carried out 2 hours after ingestion. Blood samples were also obtained at this time point and assayed for \u00a29-and 11-OH-THC levels. Results: No significant changes in threshold or frequency resolution were seen with the dosages employed in this study. Conclusions: This suggests that THC at the plasma levels attained in this study does not have a profound effect on the processing of elementary stimuli by the auditory pathway.<\/jats:p>","DOI":"10.1191\/0960327102ht258oa","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T18:04:10Z","timestamp":1033495450000},"page":"289-292","source":"Crossref","is-referenced-by-count":12,"title":["The acute effects of tetrahydrocannabinol on auditory threshold and frequency                 resolution in human subjects"],"prefix":"10.1177","volume":"21","author":[{"given":"M","family":"Mulheran","sequence":"first","affiliation":[{"name":"MRC Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster                         Road, Leicester LE1 9HN, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Henry","sequence":"additional","affiliation":[{"name":"Academic Department of Accident and Emergency Medicine, Imperial College                         School of Medicine, St. Mary's Hospital, London W2 1NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,6,1]]},"reference":[{"key":"atypb1","first-page":"532","volume-title":"The pharmacological basis of therapeutics","author":"Jaffe JH.","year":"1987"},{"key":"atypb2","volume-title":"Marijuana and health: report of study","author":"Institute of Medicine","year":"1982"},{"key":"atypb3","volume-title":"National survey on drug abuse: main findings 1982. 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