{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:37:47Z","timestamp":1778042267633,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>`Maqianzi\u2019 (the dried ripe seed of Strychnos nux-vomica L.) contains 1.0\u20131.4% each of strychnine and brucine. After processing to reduce its toxicity, `maqianzi\u2019 was used as a herbal remedy for rheumatism, musculoskeletal injuries and limb paralysis. A 42-year old woman with neck pain was prescribed 15 g of `maqianzi\u2019 to be taken in two doses at 7 hours apart, although the recommended dose was 0.3\u20130.6 g. She was apparently well after drinking the first of two bowls of `maqianzi\u2019 decoction. One hour after she drank the second bowl of herbal decoction, she suddenly developed tonic contractions of all her limb muscles and carpopedal spasm lasting 5 min, difficulty in breathing, chest discomfort and perioral numbness. The second bowl of decoction probably became more concentrated because of evaporation of water during continued boiling and contained a larger amount of `maqianzi\u2019. On arrival in the hospital 1 hour later, she complained of muscle pain and tiredness. She was found to have hyperventilation and weakness of four limbs, with muscle power of grade 5\u2013\/5. All her symptoms gradually subsided over the next few hours. This case illustrated that `maqianzi\u2019 can cause strychnine poisoning even after processing, especially when the recommended dose is greatly exceeded. In any patient with `unexplained\u2019 muscle spasms or convulsions, strychnine poisoning should be included in the differential diagnosis and they should be asked about the use of herbal medicines.<\/jats:p>","DOI":"10.1191\/0960327102ht259cr","type":"journal-article","created":{"date-parts":[[2002,9,20]],"date-time":"2002-09-20T15:15:15Z","timestamp":1032534915000},"page":"467-468","source":"Crossref","is-referenced-by-count":26,"title":["Herbal medicine causing likely strychnine poisoning"],"prefix":"10.1177","volume":"21","author":[{"given":"T Y K","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine and                         Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital,                         Shatin, New Territories, Hong Kong, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1142\/0284"},{"key":"atypb2","first-page":"151","volume":"23","author":"Chen X","year":"1998","journal-title":"Chung Kuo Chung Yao Tsa Chih"},{"key":"atypb3","volume-title":"Ellenhorn\u2019 medical toxicology. Diagnosis and treatment of poisoning","author":"Ellenhorn MJ","year":"1997"},{"key":"atypb4","first-page":"248","volume":"17","author":"Zhu T","year":"1992","journal-title":"Chung Kuo Chung Yao Tsa Chih"},{"key":"atypb5","first-page":"963","volume":"26","author":"Kulkarni ML","year":"1989","journal-title":"Indian Pediatr"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-6757(96)90157-6"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0960327102ht259cr","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0960327102ht259cr","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:48:28Z","timestamp":1777448908000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0960327102ht259cr"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1191\/0960327102ht259cr"],"URL":"https:\/\/doi.org\/10.1191\/0960327102ht259cr","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}