{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:39:34Z","timestamp":1777667974584,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>\n                    In this study, we have investigated the relationship between lidocaine metabolism and premedication, i.e., psychotropic and anti-anxiety agents (diazepam, midazolam), hypnotics (pentobarbital, thiamylal), depolarizing muscular relaxants (vecuronium, pancuronium and suxamethonium), an active anti-hypertensive (clonidine) and an H\n                    <jats:sub>2<\/jats:sub>\n                    receptor antagonist (cimetidine) using rat hepatic microsomes in vitro. Lidocaine metabolism was noncompetitively inhibited by midazolam (K\n                    <jats:sub>i<\/jats:sub>\n                    =29.0 mM). Thilamylal was a moderate competitive inhibitor of lidocaine metabolism (K\n                    <jats:sub>i<\/jats:sub>\n                    =77.8 mM). Pentobarbital, diazepam and cimetidine weakly inhibited lidocaine metabolism formation in a concentration-dependent manner at high substrate concentrations. On the other hand, vecuronium, pancuronium, suxamethonium and clonidine did not inhibit lidocaine metabolism over the therapeutic range. These results show that the interaction between lidocaine and midazolam and thiamylal, catalyzed by a similar cytochrome P450, is of potential importance in toxicological and clinical studies.\n                  <\/jats:p>","DOI":"10.1191\/0960327102ht279oa","type":"journal-article","created":{"date-parts":[[2002,9,20]],"date-time":"2002-09-20T15:15:15Z","timestamp":1032534915000},"page":"453-456","source":"Crossref","is-referenced-by-count":2,"title":["A study of the in vitro clinical interaction between lidocaine and                 premedications using rat liver microsomes"],"prefix":"10.1177","volume":"21","author":[{"given":"A","family":"Nagashima","sequence":"first","affiliation":[{"name":"Institute of Community Medicine, University of Tsukuba, Ibaraki-ken                         305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Institute of Community Medicine, University of Tsukuba, Tsukuba-shi,                         Ibaraki-ken 3058575, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Inomata","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken                         305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Misawa","sequence":"additional","affiliation":[{"name":"Institute of Community Medicine, University of Tsukuba, Ibaraki-ken                         305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"atypb1","first-page":"11","volume":"13","author":"Tanaka E","year":"1995","journal-title":"Jpn J Forensic Toxicol"},{"key":"atypb2","first-page":"1385","volume":"255","author":"Imaoka S","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90654-0"},{"key":"atypb4","first-page":"296","volume":"25","author":"Nakamoto T","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"atypb5","first-page":"89","volume":"36","author":"Kronbach T","year":"1989","journal-title":"Mol Pharmacol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200009000-00045"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.3109\/00498259609050260"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1993.tb01551.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1993.25"},{"key":"atypb10","first-page":"511","volume":"82","author":"Olkkola KT","year":"1996","journal-title":"Anesth Analg"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050513"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1999.tb00890.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199610000-00009"},{"key":"atypb14","first-page":"1302","volume":"47","author":"Kakinohara M","year":"1998","journal-title":"Masui"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0960327102ht279oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0960327102ht279oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:48:29Z","timestamp":1777448909000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0960327102ht279oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1191\/0960327102ht279oa"],"URL":"https:\/\/doi.org\/10.1191\/0960327102ht279oa","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}