{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:13:41Z","timestamp":1777666421581,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>The possible reproductive adverse effects of the pesticide endosulfan on male offspring rats exposed in utero and during lactation were investigated. Dams were treated orally with 0, 0.5 or 1.5 mg of endosulfan\/kg 21 days prior to mating, during the mating, pregnancy and lactation. Maternal and reproductive outcome data and male sexual development landmarks (testis descent and preputial separation) were assessed. Reproductive endpoints of the male offspring were examined at adulthood: sex organ weights, daily sperm production, spermatid number, sperm transit, sperm morphology and testosterone level. No signs of maternal toxicity were detected at the dose levels tested. Sexual development landmarks were also unaffected. Moreover, with the exception of a significant increase in the relative epididymis weight seen in the group treated with the lowest dose, we have not found any statistically significant adverse effect in the reproductive endpoints investigated at adulthood. The results of the present study indicate that pre and post-natal exposure to low doses of endosulfan (0.5 and 1.5 mg\/kg) do not induce significant adverse effects in the reproductive system of male offspring Wistar rats at adulthood.<\/jats:p>","DOI":"10.1191\/0960327103ht351oa","type":"journal-article","created":{"date-parts":[[2003,4,28]],"date-time":"2003-04-28T18:12:40Z","timestamp":1051553560000},"page":"171-175","source":"Crossref","is-referenced-by-count":27,"title":["Pre and postnatal exposure to endosulfan in Wistar rats"],"prefix":"10.1177","volume":"22","author":[{"given":"Paulo R","family":"Dalsenter","sequence":"first","affiliation":[{"name":"Departamento de Farmacologia, Setor de Ciencias Biol\u00f3gicas                         Centro Polit\u00e9cnico, Universidade Federal do Paran\u00e1,                         81531-990 Curitiba\/PR, Brazil; Department of                         Pharmacology, Federal University of Paran\u00e1, Curitiba\/PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samanta L","family":"deAra\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena C","family":"da Silva de Assis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson JM","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of Paran\u00e1,                         Curitiba\/PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Dallegrave","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"atypb1","unstructured":"Environmental Protection Agency (EPA)                 . 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