{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:14:12Z","timestamp":1777666452307,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>\n                    The aim of this study was to investigate the hematological, hemostatic and biochemical disturbances induced by the injection of Crotalus durissus terrificus venom in dogs under controlled conditions. For this purpose three groups of animals were used: an experimental group (E), which was injected i.m. with C. durissus terrificusvenom (1 mg\/kg); and two control groups\n                    <jats:sup>\/<\/jats:sup>\n                    antivenom\n                    <jats:sup>\/<\/jats:sup>\n                    which were injected i.m. with 150 mM NaCl. Groups E and AV were treated i.v. withCrotalus antivenom 2 hours after the first injection. Serum levels of alkaline phosphatase and alanine aminotransferase were increased in groups E and AV at 24 and 48 hours after serumtherapy, respectively. The increased serum levels of myoglobin, creatine kinase and aspartate aminotransferase demonstrated that animals developed rhabdomyolysis. A persistent neutrophilic leukocytosis was already noticeable at 2 hours after envenomation and lasted even after serumtherapy. The animals of groups E and AV presented eosinopenia 24 hours after serumtherapy, and collagen-induced platelet hypoaggregation was observed without thrombocytopenia. Increased levels of fibrinogen\/fibrin degradation products (FnDP\/FgDP), hypofibrinogenemia, and a\n                    <jats:sub>2<\/jats:sub>\n                    -antiplasmin consumption were observed at 2 hours after envenomation, indicating secondary activation of fibrinolysis. Our data suggest that the biochemical and hemostatic disturbances induced by C. durissus terrificus venom in dogs are related to its myotoxic and thrombin-like activities.\n                  <\/jats:p>","DOI":"10.1191\/0960327103ht392oa","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T07:45:16Z","timestamp":1068623116000},"page":"491-500","source":"Crossref","is-referenced-by-count":23,"title":["Hematological, hemostatic and clinical chemistry disturbances induced by                 Crotalus durissus terrificus snake venom in dogs"],"prefix":"10.1177","volume":"22","author":[{"given":"M CC","family":"de sousa-e-Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia, Instituto Butantan, Av. Vital                         Brazil 1500, CEP 05503900, S\u00e3o Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S C","family":"Tomy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F L","family":"Tavares","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia, Instituto Butantan, Av. Vital                         Brazil 1500, Caixa Postal 05503-900, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Navajas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M HMA","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S RR","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Kogika","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u013anica M\u00e9dica da Faculdade de                         Medicina Veterin\u00e1ria e Zootecnia da USP, S\u00e3o Paulo,                         SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I S","family":"Sano-Martins","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia, Instituto Butantan, Av. Vital                         Brazil 1500, Caixa Postal 05503-900, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"atypb1","first-page":"9","author":"Minist\u00e9rio da Sa\u00fade","year":"1991","journal-title":"Funda\u00e7\u00e3o Nacional da Sa\u00fade"},{"key":"atypb2","first-page":"212","volume":"26","author":"Vital Brazil O","year":"1980","journal-title":"Rev Ass Med Bras"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(85)90367-8"},{"key":"atypb4","first-page":"355","volume":"12","author":"Nahas L","year":"1964","journal-title":"Thromb Diath Haemorr"},{"key":"atypb5","first-page":"505","volume":"12","author":"Slotta KH","year":"1938","journal-title":"Mem Inst Butantan"},{"key":"atypb6","first-page":"141","volume":"22","author":"Moura-Gon\u00e7alves J","year":"1950","journal-title":"An Acad Bras Ci\u00eanc"},{"key":"atypb7","first-page":"224","volume":"11","author":"Barrio A","year":"1961","journal-title":"Acta Physiol Latinoamericana"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(81)90085-4"},{"key":"atypb9","first-page":"333","volume":"19","author":"Raw I","year":"1986","journal-title":"Braz J Med Biol Res"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(76)90010-6"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(78)90056-9"},{"key":"atypb12","first-page":"34","volume":"212","author":"Vital Brazil O","year":"1971","journal-title":"J Physiol"},{"key":"atypb13","first-page":"61","volume":"122","author":"Santoro ML","year":"1999","journal-title":"Comp Biochem Physiol"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(87)90134-6"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(78)90457-9"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(84)90162-4"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(00)00245-2"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/94.10.551"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-138902-4.50021-0"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651986000400003"},{"key":"atypb21","first-page":"63","volume":"23","author":"Amorim MF","year":"1951","journal-title":"Mem Inst Butantan"},{"key":"atypb22","first-page":"18","volume":"5","author":"Sousa-e-Silva MCC","year":"1996","journal-title":"Mediat In flamm"},{"key":"atypb23","volume":"34","author":"Jorge MT","year":"1992","journal-title":"Rev Inst Med Trop S\u00e3 o Paulo"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1980.29.1453"},{"key":"atypb25","first-page":"303","volume":"28","author":"Sano-Martins IS","year":"1995","journal-title":"J Med Biol Res"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-191304000-00004"},{"key":"atypb27","first-page":"316","volume":"37","author":"Ratnoff OD","year":"1951","journal-title":"J Lab Clin Med"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(80)90024-8"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651986000400004"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651991000400002"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.7.1522"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1995.tb00542.x"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90044-2"},{"key":"atypb34","first-page":"169","volume":"113","author":"Rossi MA","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"atypb35","first-page":"364","volume-title":"Clinical biochemistry of domestic animals","author":"Cornellius CE","year":"1989"},{"key":"atypb36","first-page":"137","volume":"34","author":"Amorim MF","year":"1969","journal-title":"Mem Inst Butantan"},{"key":"atypb37","first-page":"315","volume":"86","author":"Cardoso JLC","year":"1993","journal-title":"Q J Med"},{"key":"atypb38","first-page":"731","volume-title":"Schalm's veterinary hematology","author":"Jain NC","year":"1986"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(81)90103-3"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649679"}],"container-title":["Human &amp; 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