{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:17:25Z","timestamp":1788481045148,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>\n                    HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifoliahas been evaluated for hepatoprotective activity against carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro). HP-1 attenuated the serum toxicity as manifested in elevated levels of transaminases (glutamate oxaloacetate transaminase (GOT), and GPT) The anti-oxidative enzymes in liver (catalase and superoxide dismutase (SOD)) were restored to normal values after the oral administration of HP-1. HP-1 suppressed the formation of the superoxide anion radical and reduced CCl\n                    <jats:sub>4<\/jats:sub>\n                    mediated lipid peroxidation (LPO). Silymarin and antioxidants (ascorbic acid,\u03b2-carotene and tocopherol) were used for comparison. The present study showed that HP-1 is a potential hepatoprotective formulation with an additional attribute of being anti-peroxidative.\n                  <\/jats:p>","DOI":"10.1191\/0960327103ht406oa","type":"journal-article","created":{"date-parts":[[2004,2,12]],"date-time":"2004-02-12T17:05:35Z","timestamp":1076605535000},"page":"639-645","source":"Crossref","is-referenced-by-count":41,"title":["Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine"],"prefix":"10.1177","volume":"22","author":[{"given":"S A","family":"Tasaduq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S C","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Bedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B S","family":"Jaggi","sequence":"additional","affiliation":[{"name":"Biochemistry Lab, Division of Pharmacology, Regional Research Laboratory,                         Canal Road, Jammu-Tawi 180 001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R K","family":"Johri","sequence":"additional","affiliation":[{"name":"Biochemistry Lab, Division of Pharmacology, Regional Research Laboratory,                         Canal Road, Jammu-Tawi 180 001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,12,1]]},"reference":[{"key":"atypb1","volume-title":"Dehradun","author":"Kiritikar KR","year":"1987"},{"key":"atypb2","volume-title":"Ayurvedic drugs and their plant sources","author":"Sivarajan VV","year":"1994"},{"key":"atypb3","first-page":"27","volume":"84","author":"Venkateshwaran PS","year":"1987","journal-title":"Proc Nat Acad Sci USA"},{"key":"atypb4","unstructured":"Rohatgi S                 . Ayurvedic composition for the prophylaxis andtreatment of AIDS,                     \u2018u, TB and other immunodeficiencies and the process for preparing the                 same. 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