{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:37:41Z","timestamp":1791067061778,"version":"4.1.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>\n                    This paper presents cytotoxicity data of selected imidazolium ionic liquids evaluated in vitro on the human tumor cell line HeLa. It was found that for 1-n-butyl-3-methylimidazolium entities the toxicity depends strongly on the associated anion; EC\n                    <jats:sub>50<\/jats:sub>\n                    values are lowest for tetrafluoroborate. No direct dependence of the reduced effect concentration was found on elongating the short, methyl chain to ethyl or n-hexyl. Only for the ionic liquid with an n-decyl chain, the longest one studied, did higher hydrophobicity result in a EC\n                    <jats:sub>50<\/jats:sub>\n                    one order of magnitude lower than that obtained with the n-butyl entity. The effect concentrations of imidazolium ionic liquids in the HeLa system used are lower than the values obtained for conventional organic solvents such as dichloromethane, toluene or xylene.\n                  <\/jats:p>","DOI":"10.1191\/0960327104ht480oa","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T17:14:06Z","timestamp":1100193246000},"page":"513-517","source":"Crossref","is-referenced-by-count":222,"title":["Evaluating the cytotoxicity of ionic liquids using human cell line HeLa"],"prefix":"10.1177","volume":"23","author":[{"given":"P","family":"Stepnowski","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, University of Gda\u0144sk, PL 80-952                         Gday\u0144sk, ul. Sobieskiego 18, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C","family":"Skladanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ludwiczak","sequence":"additional","affiliation":[{"name":"Intercollegiate Faculty of Biotechnology, Medical University of Gda\u0144sk & University of Gda\u0144sk, ul. Debinki 1, 80-211 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Laczy\u0144ska","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Gdan\u0144sk, PL 80-952                         Gda\u0144sk, ul. Sobieskiego 18, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980032t"},{"key":"atypb2","first-page":"223","volume":"1","author":"Holbrey JD","year":"1999","journal-title":"Clean Prod Process"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20001103)112:21<3926::AID-ANGE3926>3.0.CO;2-U"},{"key":"atypb4","first-page":"2399","volume-title":"Chem Commun","author":"Sheldon R","year":"2001"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1021\/cr010338r"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-860X(01)00834-1"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1039\/b211971d","volume":"5","author":"Jastorff B","year":"2003","journal-title":"Green Chem"},{"key":"atypb8","volume-title":"Ecotox Environ Safety","author":"Ranke J","year":"2003"},{"key":"atypb9","volume-title":"9th FECS Conference on Chemistry and the Environment","author":"Stepnowski P"},{"key":"atypb10","first-page":"396","volume":"28","author":"Sk\u0142adanowski AC","year":"2004","journal-title":"in vitro inhibition by synthetic nitro-and polycyclic musks, imidazolium ionic liquids and N-glucopyranosyl ammonium salts as a potential molecular method for prospective and retrospective risk assessment of xenobiotics. Environ Toxicol Pharmacol"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1039\/b304400a"},{"key":"atypb12","volume-title":"ACS Professional Reference Book","author":"Hansh C","year":"1995"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(97)00151-0"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0960327104ht480oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0960327104ht480oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:42:56Z","timestamp":1777448576000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0960327104ht480oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1191\/0960327104ht480oa"],"URL":"https:\/\/doi.org\/10.1191\/0960327104ht480oa","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}